The Role
Design, build, and operate multi-agent AI backends that generate fast, accurate genomics-based health guidance. Implement planners, routers, workers, evaluators, RAG pipelines, parallel execution, caching, evaluation benchmarks, and production TypeScript services integrating databases, queues, and data systems while ensuring scientific accuracy, safety, and low latency.
Summary Generated by Built In
Sequencing is building the interface between humanity and its DNA.
Using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications, we help people better understand themselves, their health, and their future through their DNA.
The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth.
As the world’s largest direct-to-consumer whole genome sequencing platform, Sequencing is helping define the future of AI-powered personalized health.
We’re a profitable, venture-backed, fully remote company building category-defining products that help people better understand themselves through their DNA.
As a Senior AI Engineer you build and improve the AI agent systems that power personalized genetics based health guidance. You work side by side with our AI Backend Architect to move from simple large language model calls to a true multi agent brain that plans routes and checks every answer. When you do this well people get fast accurate and trustworthy health insights from their whole genome instead of generic or confusing results.
- Design and improve multi agent AI systems where planner orchestrator worker and evaluator agents work together on each request.
- Build planner and router agents that decide which worker agent Genome Research Health or Drug should handle each task.
- Create AI agents that can pick use and chain tools on their own including ReAct style agents that can write and run code in a safe loop.
- Set up clear interfaces and parallel execution for worker agents so answers stay fast even as we add more data and tools.
- Build critic and review layers that check responses for quality safety and scientific accuracy before sending them to the user.
- Reduce wait times by running agents in parallel precaching likely intents and making tool calls and data access as efficient as possible.
- Build and maintain evaluation pipelines and benchmarks so we can measure answer quality response speed and reliability over time.
- Design and run production AI backend services in TypeScript that connect agents to genomics and health data.
- Build prompt flows retrieval pipelines and guardrails so models stay grounded in real genetic and health evidence not guesses.
- Integrate and run databases queues and data systems such as PostgreSQL MySQL AWS SQS Redis BullMQ and AWS Glue in the AI backend.
- Support backend systems that power native mobile apps so experiences feel fast and stable on every device.
- Work closely with bioinformatics teammates to be sure AI answers match what the DNA and science actually say.
- Partner with product and design to make AI answers feel simple caring and easy to act on for non experts.
- Help shape a self improving AI system that can learn from patterns across many users while keeping their data private and secure.
- 5+ years of backend development in production environments.
- Expert with TypeScript and comfortable owning production backend services.
- Proven experience building multi agent AI systems and orchestration patterns not just wiring up a single large language model.
- Deep hands on work with large language model APIs such as Anthropic OpenAI Bedrock DeepSeek or Google AI in real products.
- Experience building structured retrieval augmented generation pipelines and retrieval systems.
- Experience with hierarchical agent designs planner and orchestrator patterns dynamic tool use and autonomous agents.
- Experience building evaluation pipelines benchmarks and response quality scoring plus tuning systems for low latency.
- Strong understanding of how to speed up AI systems using parallel execution caching and efficient tool calls.
- Experience with PostgreSQL DuckDB Apache Spark and service oriented architectures.
- Able to work independently in a remote setup while partnering closely with product engineering and bioinformatics.
- Customer obsessed and quality driven with a strong respect for scientific accuracy and safety around health.
- Nice to have familiarity with genomics bioinformatics or health data systems agent frameworks like LangGraph AutoGen or CrewAI self improving agent loops startup environments or Rust.
- Comprehensive medical, dental, and vision insurance coverage
- 401(k) with company matching
- Paid time off (PTO)
- Paid volunteer time off
- Fully remote work with home office stipend
- Parental bonding leave
- Clinical-grade whole genome sequencing for you and your family (private and confidential)
- Redefine how people understand themselves through their DNA
- Build category-defining products alongside scientists, engineers, and innovators
- Contribute to technology that will improve and extend millions of lives
- Shape one of the most important emerging categories in AI and healthcare
Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
Sequencing Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting [email protected].
Skills Required
- 5+ years of backend development in production environments
- Expert with TypeScript and owning production backend services
- Proven experience building multi-agent AI systems and orchestration patterns
- Hands-on experience with large language model APIs (e.g., Anthropic, OpenAI, Bedrock, DeepSeek, Google AI) in real products
- Experience building retrieval augmented generation (RAG) pipelines and retrieval systems
- Experience with hierarchical agent designs, planner/orchestrator patterns, dynamic tool use, and autonomous agents
- Experience building evaluation pipelines, benchmarks, response quality scoring, and tuning for low latency
- Strong understanding of parallel execution, caching, and efficient tool calls to speed up AI systems
- Experience integrating and running databases, queues, and data systems such as PostgreSQL, MySQL, AWS SQS, Redis, BullMQ, and AWS Glue
- Experience with PostgreSQL, DuckDB, Apache Spark, and service-oriented architectures
- Ability to work independently in a remote setup and collaborate closely with product, engineering, and bioinformatics
- Customer-obsessed, quality-driven with strong respect for scientific accuracy and safety around health
- Familiarity with genomics, bioinformatics, or health data systems
- Familiarity with agent frameworks like LangGraph, AutoGen, or CrewAI
- Experience with self-improving agent loops, startup environments, or Rust
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The Company
What We Do
Sequencing.com is a genomics platform that provides clinical-grade whole genome sequencing, at-home DNA kits, and free lifetime DNA data storage. The company offers an app/report marketplace, AI-enabled interpretation, and personalized health, wellness, and ancestry reports produced from WGS data, with emphasis on privacy and ongoing updates to drive actionable insights for prevention and personalized care.
