We are seeking a detail-oriented Scientist to work in the Non-Clinical Development department overseeing bioanalytical work for Maze. In this role, you will oversee bioanalysis for Good Laboratory Practices (GLP), Good Clinical Laboratory Practices (GCLP), and non-GLP studies in support of the development of small molecule drugs. As part of the Non-Clinical Development team, you will have the opportunity to contribute to key drug discovery and development projects.
This position reports to VP, Non-Clinical Development.
The Impact You’ll Have- Oversee the development, validation, and execution of bioanalytical assays for both pharmacokinetics and pharmacodynamics for ongoing preclinical, nonclinical, and clinical programs.
- Manage the collaborations with contractor laboratories conducting bioanalysis and review data from analysis to confirm analyses were correctly conducted and batch analyses met acceptance criteria.
- Provide written summaries of bioanalytical methods for regulatory submissions as needed.
- Coordinate regulated bioanalysis activities across development programs, ensuring compliance with timelines and regulatory standards.
- Provide timeline updates to the Head of Bioanalysis, Nonclinical Development, and collaborate with key stakeholders in Research, Regulatory Affairs, Manufacturing, Quality, and Clinical Sciences to address bioanalysis-related project issues.
- Review, investigate, and coordinate resolution of study queries with contract research organization (CRO) and personnel regarding data integrity.
- Bachelor’s degree in analytical chemistry, chemistry, biochemistry, or related field.
- 6+ years of relevant experience, ideally within a pharmaceutical company, a CRO, or academia, with a focus on bioanalysis oversight.
- Experience and understanding of GLP and GCLP principles and guidances
- Experience in GLP and GCLP analysis of one or more bioanalytical techniques, including: LC-MS/MS, ELISA, and MSD
- Experience working with multidisciplinary project teams, driving successful outcomes.
- Ability to manage multiple projects simultaneously with excellent attention to detail.
- Clear and effective communication skills to present complex scientific information to various stakeholders.
Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.
Our PeopleMaze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Our Core Values
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.
The expected annual salary range for employees located in the San Francisco Bay Area is $130,000 - $159,000. Additionally, this position is eligible for an annual performance bonus.
Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.
Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.
#LI-Hybrid
Skills Required
- Bachelor's degree in analytical chemistry, chemistry, biochemistry, or related field.
- 6+ years of relevant experience with a focus on bioanalysis oversight (pharma, CRO, or academia).
- Experience and understanding of GLP and GCLP principles and guidances.
- Experience in GLP and GCLP analysis of bioanalytical techniques, including LC-MS/MS, ELISA, and MSD.
- Experience working with multidisciplinary project teams.
- Ability to manage multiple projects simultaneously with strong attention to detail.
- Clear and effective communication skills to present complex scientific information to stakeholders.
Maze Therapeutics Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Maze Therapeutics and has not been reviewed or approved by Maze Therapeutics.
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Healthcare Strength — Benefits include employer-paid comprehensive medical, dental, and vision coverage for employees worldwide with additional support for dependents. Mental-health care is described as free, confidential, and unlimited, reinforcing the depth of coverage.
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Leave & Time Off Breadth — Time-off policies feature flexible vacation, generous PTO, and companywide breaks alongside standard holidays. Extended paid parental leave for birth or adoption further expands available time away from work.
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Wellbeing & Lifestyle Benefits — Total rewards are bolstered by a flexible lifestyle budget, a personalized remote-work budget, and tech perks. Additional offerings such as retreats and referral bonuses add to day-to-day wellbeing and engagement.
Maze Therapeutics Insights
What We Do
Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. We have assembled a world-class team that we need to realize this vision, including creative scientific pioneers in genetics, experienced company builders, and biotech industry leaders.
