Colossal is looking for a talent Scientist that will take on ambitious synthetic biology projects and large-scale genome engineering for species conservation and de-extinction. The Scientist will be building tools and methodologies for engineering various cell types and will develop workflows to manipulate large DNA fragments and genomes. This position reports to the Head of Large Mammals.
This position is based on-site in Dallas, TX. Relocation assistance is available.
Duties and Responsibilities:
- Design, innovate and iterate: DNA assembly, integration, editing and screening
- Build enabling molecular and cellular tools
- Optimize gene-editing cargo delivery
- Quantify genome editing events using various molecular assays
- Improve the state of the art in CRISPR-guided precision genome editing
- Data analysis, figure generation and timely reporting of results
- Present findings at small forums and R&D meetings
- Maintain a thorough and detailed electronic lab notebook
- Maintain a clean and organized laboratory space
Required Skills and Abilities:
- Solid understanding and hands-on experience with precision editing techniques, covering the design, optimization and verification of edits made with CRISPR-Cas9, HDR, Base Editors, Prime Editors and large construct integration methods
- Experience with recombinant DNA cloning techniques, bacterial purification, primer design and PCR, gel electrophoresis, nucleic acid purification and characterization
- Comfortable with protein characterization methods and flow-cytometry
- Experience with cell culture and delivery of DNA/RNA/RNP for gene-editing
- Self-motivated, proactive, works well under pressure and deadlines, detail-oriented
- Enthusiasm for learning new skills and taking on new responsibilities
- Creative problem-solving skills
- Communicate clearly both written and orally, so others can understand.
Preferred Experience:
- High throughput screening or automation methods, especially in designing and constructing libraries and/or arrays to perform multiplexed screening experiments, such as massively parallel reporter assays (MPRA) or CRISPR interference (CRISPRi)
- Comfortable in handling large data sets and using bioinformatic tools in standard data formats (e.g., FASTA, FASTQ, BAM, VCF, GTF/GFF)
- Experience with precision editing include software and tools design (e.g., crisprVerse, CRIS.py, PrimeDesign) or predictive machine learning models for optimizing editing constructs (e.g., DeepCRISPR, CRISPRpred, PRIDICT)
- Bulk and single-cell RNA prep and sequence analyses
- Stem cell derivation, culture and characterization
Required Education and Experience:
- MS/PhD in synthetic biology, bioengineering, molecular biology, genetics or related field such as developmental biology or immunology
- 3+ years hands-on expertise in genetics and genomic manipulation
What Colossal Offers You:
- Medical, dental, and vision coverage
- Unlimited PTO and company holidays so you can rest and recharge
- Flexible spending accounts (FSA)
- Company matched 401k retirement plan
- Paid parental leave up to 12 weeks
- Education reimbursement
- An opportunity to help us return the Earth to a healthier state
The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices.
Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.
Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.
EEO is the Law
Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house.
Colossal is proud to be named a Best Place to Work by BuiltIn for 3 years in a row across multiple categories in 2023, 2024, and 2025:
- #1 on the 50 Best Startups to Work For in Dallas in 2023!
- 100 Best Midsize Places to Work in Dallas in 2024 & 2025
- 100 Best Places to Work in Dallas, TX (All Size Employers) in 2024 & 2025
- 100 Best Midsize Places to Work in Boston in 2024 & 2025
Built In 2025 Award Lists
Great Place to Work Certification Page
Most Loved Workplace Certification Page - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.
Newsweek's Most Loved Workplaces 2024 Award List - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!
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What We Do
Colossal is a breakthrough bioscience and genetic engineering company that builds radical new technologies to advance the field of genomics. Colossal creates disruptive technologies for extinct species restoration, critically endangered species protection and the repopulation of critical ecosystems that support the continuation of life on Earth. The company is the first to apply CRISPR technology for the purposes of species de-extinction, beginning with the woolly mammoth. Colossal is accepting humanity’s duty to restore Earth to a healthier state.
Why Work With Us
Colossal will revolutionize history and be the first company to use CRISPR technology successfully in the de-extinction of previously lost species. On the journey we will build radical new software tools and technologies to advance the science of genomics overall. Join our team and be proud of your contribution to science and the planet.
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