Company
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Position
Nurix Therapeutics seeks an experienced Scientist to join the Analytical Development and Quality Control group. The Scientist will conduct analytical method development and material characterization studies to inform drug substance and drug product development. They will also provide operational oversight at external CDMO/CTL partners, manage reference standards and impurity markers, collaborate in CMC risk management, and author technical reports.
In Nurix’s laboratories, the Scientist will characterize material attributes and impurities by high resolution mass spectrometric and multidimensional chromatographic techniques. They will determine impurity structures, characterize material stability, and elucidate mechanisms of degradation. They will employ state of the art QbD approaches to develop and troubleshoot chromatographic test methods to accelerate and derisk QC activities performed externally at CDMOs and CTLs. The Scientist will critically evaluate characterization data and communicate results in multidisciplinary teams.
The ideal candidate must have demonstrated expertise in mass spectrometry and hands-on experience with liquid chromatography. Hands-on experience with two-dimensional liquid chromatography is a plus.
This position is onsite at Nurix headquarters in Brisbane, CA.
Key responsibilities
- Characterization and development studies at our internal laboratory:
- 2D-LC for impurity profiling of complex samples, derisking HPLC test procedures, and adaptation of incompatible methods to mass spectrometry
- Structural elucidation by high resolution Orbitrap Tribrid Mass Spectrometry
- QbD HPLC method development using multivariate DOE software
- Forced degradation and elucidation of degradation mechanisms
- Accelerated predictive stability studies and modeling of packaging configurations and long term stability
- Authorship of technical documents such as analytical development reports, stability reports, and storage statements
- Management of reference standards and impurity markers
- Manage and organize documentation and data
- Contribute to protocol development and oversight/troubleshooting of method transfers
- Liaise with Medicinal Chemistry, Bioanalytical, DMPK, and Preclinical departments
- Compliance with cGMP quality standards and internal SOPs
- Travel up to 5%
Required Qualifications
- Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field). BS with 10+ years, MS degree with 6+ years, or PhD with up to 4 years of relevant experience
- Expertise in operation and maintenance of mass spectrometers
- Experience in HPLC operation and method development
- Ability to critically interpret data and articulate technical concepts in cross functional teams
- Ability to ensure assigned activities are completed to the satisfaction of project timelines
- Strong interpersonal skills that foster collaboration within and outside of the organization
Bonus Qualifications
- Experience with accurate mass instrumentation such as Orbitrap Tribrid mass spectrometers
- Experience in operation of 2D-LC
- Experience in the determination of structures of small molecule impurities and/or metabolites
- Experience protein and/or ADC characterization by mass spectrometry
- Familiarity with gas chromatography, NMR, particle size analysis, solid state characterization, dissolution, ICP-MS/OES, and/or FTIR
- Experience with reference standard management, stability programs, and/or method validation
- Familiarity with ICH guidelines, cGMPs, and pharmacopeial chapters
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
Salary Range
Scientist I : $123,841--$144,272
Scientist II: $143,260 –$161,064
Application Process
Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.
Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).
Skills Required
- Advanced degree in Chemistry, Pharmaceutics, or related field
- Expertise in operation and maintenance of mass spectrometers
- Experience in HPLC operation and method development
- Ability to critically interpret data and articulate technical concepts
- Strong interpersonal skills for collaboration
- PhD with up to 4 years of relevant experience or MS degree with 6+ years or BS with 10+ years
What We Do
Nurix Therapeutics discovers drugs that harness the body's natural process to control protein levels. Our drugs control ubiquitin E3 ligases, the key enzymes responsible for protein breakdown in human cells, as a unique therapeutic approach to treat a broad range of diseases. Our focus is on developing drugs to treat cancer including novel, small molecule immuno-oncology agents
