OpenEye, Cadence Molecular Sciences – a division of Cadence Design Systems – is an industry leader in computational molecular design through rapid, robust, and scalable software, consulting services, and Orion®, the only cloud-native fully integrated software-as-a-service molecular modeling platform. Combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in a customizable development platform, Orion offers unprecedented capabilities for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances.
We are looking for a Computational Chemist/Cheminformatician to join our team of experts in mathematics, computational modeling, and medicinal chemistry. This highly focused team will work together to drive forward technology which leverages OpenEye’s Orion platform to better enable scientists in the pharmaceutical industry working on projects from lead development to clinical candidate selection. This role will require interactions with customers and OpenEye’s scientific and technical teams.
What you’ll do:
- Extend OpenEye’s programming toolkits by developing and implementing new and useful scientific and technical features to aid customers in developing bespoke solutions.
- Explore methods for further enhancing OpenEye’s virtual screening platform (including OMEGA, ROCS, FastROCS, ROCS X, OEDocking).
- Apply chemistry/cheminformatics expertise with ML experts to build robust, scalable models to support data-driven decision making.
- Work on retrospective and prospective projects both internally and with collaborators to validate methodologies.
- Work with Orion project team to further optimize compound design workflows in Orion.
What you should have:
- PhD (or equivalent experience) in computational chemistry, chemistry, cheminformatics, or related field with 0 – 3 years relevant experience
- Knowledge of some traditional computational chemistry approaches such as docking, virtual screening, molecular modeling, etc.
- Programming expertise, ideally in c++ and/or python preferably with experience using AI coding agents
- Experience in or desire to learn about the pharmaceutical industry
- Strong desire to find practical solutions to challenging problems
- Demonstrated ability to work both as part of a team and independently
The following are a PLUS, but not required:
- Experience with OpenEye software/toolkits
- Experience with synthetically accessible, pharmaceutically relevant generative chemistry
The annual salary range for Massachusetts is $101,500 to $188,500. You may also be eligible to receive incentive compensation: bonus, equity, and benefits. Sales positions generally offer a competitive On Target Earnings (OTE) incentive compensation structure. Please note that the salary range is a guideline and compensation may vary based on factors such as qualifications, skill level, competencies and work location. Our benefits programs include: paid vacation and paid holidays, 401(k) plan with employer match, employee stock purchase plan, a variety of medical, dental and vision plan options, and more.
We’re doing work that matters. Help us solve what others can’t.Skills Required
- PhD (or equivalent experience) in computational chemistry, chemistry, cheminformatics, or related field with 0-3 years relevant experience
- Knowledge of computational chemistry approaches such as docking, virtual screening, and molecular modeling
- Programming expertise in C++ and/or Python, preferably with experience using AI coding agents
- Experience in or desire to learn about the pharmaceutical industry
- Strong desire to find practical solutions to challenging problems
- Demonstrated ability to work both as part of a team and independently
- Experience with OpenEye software/toolkits
- Experience with synthetically accessible, pharmaceutically relevant generative chemistry
Cadence Design Systems Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Cadence Design Systems and has not been reviewed or approved by Cadence Design Systems.
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Equity Value & Accessibility — A discounted ESPP with a lookback feature and equity included in total compensation make ownership broadly accessible and potentially meaningful. Structured compensation at an industry leader adds predictability to equity participation.
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Healthcare Strength — Medical, dental, and vision coverage are described as solid, with mental‑health/EAP and fertility support enhancing the offering. The breadth across core care and family‑building needs strengthens the healthcare package.
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Leave & Time Off Breadth — Global Recharge Days, volunteer time off, and companywide breaks indicate a comprehensive time‑off framework. In addition, many salaried roles are described as having flexible or generous PTO policies.
Cadence Design Systems Insights
What We Do
Cadence enables electronic systems and semiconductor companies to create the innovative end products that are transforming the way people live, work and play. Cadence® software, hardware and IP are used by customers to deliver products to market faster. The company's Intelligent System Design strategy helps customers develop differentiated products—from chips to boards to intelligent systems—in mobile, consumer, cloud, data center, automotive, aerospace, IoT, industrial and other market segments. Cadence is listed as one of Fortune Magazine's 100 Best Companies to Work For.
