OpenEye, Cadence Molecular Sciences, an industry leader in computational molecular design, uses a scientific approach to deliver rapid, robust, and scalable software, toolkits, and technology & design services for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances. We are passionate about science and about taking care of our team members, with leaders supporting your development and recognizing your contributions by providing an unmatched total compensation package in a collaborative, caring, energetic and fun work environment.
The Affinity Group at OpenEye seeks to hire a scientific software developer to join a growing team delivering Molecular Dynamics (MD) based solutions for predicting protein-ligand binding affinities. Within OpenEye’s Cloud-based platform Orion, our team has already delivered to our clients massively parallel Relative Binding Free Energy (RBFE) tools capable of calculating affinities on dozens of ligands in only hours, using hundreds of GPUs. We are also developing faster, higher throughput MD-based prescreening approaches to use upstream of the heavier free energy methods. With your experience in MD and programming, you will help us to extend our capabilities in this area, making both our science and our tools better: more robust, more accurate, and more efficient. The work you do will have a high impact, contributing to the science of many organizations, both industry-based and academic. In this you will be collaborating with experienced scientific developers with expertise in small molecule drug discovery and long track records of delivering useful solutions and liaising with academic collaborators in the simulations community.
Please include a cover letter.
What you should have:
- PhD. with PostDoc in an area related to structure-based ligand design methods.
- 3 or more years of experience in scientific programming with Python.
- 3 or more years of experience with Molecular Dynamics including Free Energy Calculations.
- Experience in computational chemistry methods development, implementation, and validation
- Team-oriented with good communication skills and professional scientific presentation skills.
- Ability and desire to learn new ideas and adapt to new development practices
The following are a PLUS, but not required:
- Knowledge & skill in programming and professional software development practices & tools
- Experience with a multi platform and/or distributed computing environment including cloud computing.
- Knowledge of chemistry and/or drug discovery & development
Benefits:
OpenEye is passionate about the welfare of its employees and offers competitive benefits that include medical, dental, vision, flexible working schedule, 401k retirement plans, paid vacation, paid sick leave, home internet costs, public transportation reimbursement, and much more.
Skills Required
- PhD with PostDoc in structure-based ligand design methods
- 3 or more years of experience in scientific programming with Python
- 3 or more years of experience with Molecular Dynamics including Free Energy Calculations
- Experience in computational chemistry methods development, implementation, and validation
- Team-oriented with good communication skills
- Ability and desire to learn new ideas
Cadence Design Systems Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Cadence Design Systems and has not been reviewed or approved by Cadence Design Systems.
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Equity Value & Accessibility — A discounted ESPP with a lookback feature and equity included in total compensation make ownership broadly accessible and potentially meaningful. Structured compensation at an industry leader adds predictability to equity participation.
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Healthcare Strength — Medical, dental, and vision coverage are described as solid, with mental‑health/EAP and fertility support enhancing the offering. The breadth across core care and family‑building needs strengthens the healthcare package.
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Leave & Time Off Breadth — Global Recharge Days, volunteer time off, and companywide breaks indicate a comprehensive time‑off framework. In addition, many salaried roles are described as having flexible or generous PTO policies.
Cadence Design Systems Insights
What We Do
Cadence enables electronic systems and semiconductor companies to create the innovative end products that are transforming the way people live, work and play. Cadence® software, hardware and IP are used by customers to deliver products to market faster. The company's Intelligent System Design strategy helps customers develop differentiated products—from chips to boards to intelligent systems—in mobile, consumer, cloud, data center, automotive, aerospace, IoT, industrial and other market segments. Cadence is listed as one of Fortune Magazine's 100 Best Companies to Work For.
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