Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
SummaryIn consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication. Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary.
Does this position require Patient Care? No
Essential Functions
-Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field.
-Contributes to the design and execution of experiments and/or research projects.
-Exercises judgment in selecting methods and technologies to obtain results.
-May collaborate with external researchers and/or receive external project funding support.
-Presents results and prepares publications.
-May assist PI in the training and supervision of other staff.
Qualifications
This position in the BWH Center for Cellular Profiling offers the opportunity to join a group studying single-cell and Spatial organization in disease pathology. Our Center performs a combination of high-dimensional analyses, including single-cell RNA sequencing, spatial transcriptomics, and high-dimensional flow cytometry. Under general supervision by Drs. Brenner and Wei, and in accordance with established hospital policies and procedures, the self-motivated individual will perform activities related to the single-cell genomics and or flow cytometry cell sorting, including NGS library generation, 10X Genomics workflow (Chromium, Visium, and Xenium), and or familiarize with BD or Sony cell sorters and analyzers. Responsibilities includes the implementation and execution of single-cell and novel spatial transcriptomic techniques. In addition, the candidate will supervise trainees and technicians to perform NGS and 10X Genomics pipelines. The candidate will also conduct consultation with investigators and core users, perform troubleshooting, and work with administrative directors to support budget development and planning.
1. Designs and performs high-level, complex experiments independently.
2. Perform Single-cell Transcriptomics Experiments.
a. Cell capture, NGS library generation,
b. Plan library sequencing strategies.
c. Review sequencing data
d. troubleshoot techniques
3. Perform High-Parameters Flow Cytometry Experiments
a. Perform cell sorting
b. Maintenance of the cell sorters and analyzers
c. Identify and resolve technical issues with flow cytometry instruments, maintaining equipment, and ensuring quality control.
4.Supervise research assistant trainees.
5.Provide consultation with new investigators and researchers
6.Maintain supplies inventory in accordance with laboratory and department procedures.
7.Assist in the orientation and training of new students, technicians, and fellows 8.Maintain established department policies, procedures and objectives, including the areas of quality assurance, safety, environmental and infection control. 9. Perform other duties as directed.
Education
Doctorate Related Field of Study required
Can this role accept experience in lieu of a degree?
No
Licenses and Credentials
Experience
Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required
Knowledge, Skills and Abilities
- Excellent research skills.
- Demonstrated evidence of specific scientific competence in field.
- Demonstrated broad knowledge of field.
- Evidence of potential for scientific creativity and original though.
- Able to exercise independent judgment and leadership.
- Ability to contribute to publications.
Additional Job Details (if applicable)
Physical Requirements
- Standing Frequently (34-66%)
- Walking Frequently (34-66%)
- Sitting Occasionally (3-33%)
- Lifting Frequently (34-66%) 35lbs+ (w/assisted device)
- Carrying Frequently (34-66%) 20lbs - 35lbs
- Pushing Occasionally (3-33%)
- Pulling Occasionally (3-33%)
- Climbing Rarely (Less than 2%)
- Balancing Frequently (34-66%)
- Stooping Occasionally (3-33%)
- Kneeling Occasionally (3-33%)
- Crouching Occasionally (3-33%)
- Crawling Rarely (Less than 2%)
- Reaching Frequently (34-66%)
- Gross Manipulation (Handling) Frequently (34-66%)
- Fine Manipulation (Fingering) Frequently (34-66%)
- Feeling Constantly (67-100%)
- Foot Use Rarely (Less than 2%)
- Vision - Far Constantly (67-100%)
- Vision - Near Constantly (67-100%)
- Talking Constantly (67-100%)
- Hearing Constantly (67-100%)
Remote Type
Work Location
Scheduled Weekly Hours
Employee Type
Work Shift
EEO Statement:
At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
Top Skills
What We Do
Mass General Brigham is an integrated academic health care system, uniting great minds to solve the hardest problems in medicine for our communities and the world. Mass General Brigham connects a full continuum of care across a system of academic medical centers, community and specialty hospitals, a health insurance plan, physician networks, community health centers, home care, and long-term care services. Mass General Brigham is a nonprofit organization that is committed to patient care, research, teaching, and service to the community. In addition, Mass General Brigham is one of the nation’s leading biomedical research organizations and a principal teaching affiliate of Harvard Medical School.
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