The Role
Perform automated and manual high-throughput DNA preparation, protein expression, and characterization. Operate liquid handlers and analytical instruments, optimize laboratory processes, support reagent manufacturing, document experiments, develop SOPs, and improve production workflows. Collaborate with multidisciplinary teams in a dynamic biotech environment while managing multiple projects and scheduled shifts.
Summary Generated by Built In
The role: BigHat Biosciences is seeking a self-motivated individual for a Research Associate II, Production role to power our high-throughput, automated platform for antibody production and deep molecular characterization.
Key Responsibilities
- Perform automated and manual high-throughput processing on the BigHat platform, including DNA preparation, protein expression, and protein characterization.
- Contribute to the scaling up of BigHat’s platform and production-grade data generation.
- Support BigHat’s Platform Reagents & Assay Support (PRAS) function by contributing to in-house reagent manufacturing efforts.
- Execute experiments to optimize the performance efficiency of BigHat’s platform.
- Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges.
- Collaborate on the creation of laboratory standard operating procedures (SOPs) for sample processing.
- Collaborate closely with BigHat team members to identify, design, and implement critical process and operational improvements to production workflows and laboratory systems.
- Operate automated liquid handlers and analytical instruments to ensure all lab and platform operations run efficiently.
Skills Knowledge and Expertise
- BS in Biology or Chemistry, with 2+ year(s) of industry experience
- Experience in process execution, laboratory method development, optimization, and troubleshooting.
- Ability and willingness to work specific workday schedules as needed, for example 7AM to 3PM or 10AM to 6PM.
- Hands-on experience with, or interest in, automated liquid handlers (e.g. Hamilton, OpenTrons, Tecan, Agilent systems). Experience with LIMS is a nice-to-have.
- Experience with molecular biology techniques and general lab practices.
- Efficient time management and ability to work on several projects simultaneously, in a dynamic start-up environment.
- Strong interpersonal skills and ability to effectively communicate with members of a multidisciplinary team.
- Excellent record keeping abilities to document experimental work and analytical data.
- Nice-to-haves include previous experience working with barcoding systems, inventory tracking, and experience with Google Workspace tools (Docs, Sheets, Slides, etc.)
Total Rewards
The salary estimated for this position is $88,000 - $100,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
About
BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these design capabilities to develop new generations of safer and more effective treatments for patients suffering from today’s most challenging diseases.BigHat is a Series B biotech outside San Francisco with a team-oriented, inclusive, and family-friendly culture. Our broad pipeline of wholly-owned and partnered therapeutic programs span many disparate indications with high unmet need, such as cancer, inflammation, and infectious disease. BigHat has raised >$100M from top investors, including Section 32, a16z, and 8VC.
Skills Required
- Bachelor of Science degree in Biology or Chemistry
- 2+ years of industry experience
- Experience in process execution, laboratory method development, optimization, and troubleshooting
- Ability and willingness to work assigned schedules, including 7 AM to 3 PM or 10 AM to 6 PM
- Hands-on experience with or interest in automated liquid handlers
- Experience with molecular biology techniques and general laboratory practices
- Efficient time management and ability to manage multiple projects simultaneously
- Strong interpersonal and multidisciplinary communication skills
- Excellent record-keeping and experimental documentation abilities
- Experience with LIMS
- Experience with barcoding systems and inventory tracking
- Experience with Google Workspace tools, including Docs, Sheets, and Slides
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The Company
What We Do
BigHat’s mission is to improve human health by making it far easier to design advanced, next-generation antibody therapeutics. Our AI-enabled experimental platform integrates a high-speed characterization or “wet” lab with machine learning technologies to speed the antibody engineering process. When applied, these design capabilities have the potential to drive the development of new generations of safer and more effective treatments for patients suffering from today’s most challenging diseases. BigHat is backed by Section 32, Andreessen Horowitz, 8VC, Amgen Ventures, Bristol Myers Squibb, Quadrille, Grids Capital, AME Cloud Ventures, Innovation Endeavors and Gaingels.
