About AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.
Job DescriptionFor the Principal Research Scientist I position, we are seeking a highly motivated, experienced analytical scientist to be an Analytical Project Leader in New Chemical Entities (NCEs) drug substance and drug product in both preclinical and clinical programs. The candidate should have extensive expertise within an R&D environment with a fit for purpose mindset. Expertise with synthetic molecules in solid oral dosage forms is expected. Additional experience with lipid nanoparticles highly desired.
The qualified candidate should be able to conceive, execute and communicate novel strategies that achieve project goals and department imperatives across a multi-disciplinary research and development organization. They must have experience as an analytical project lead and demonstrate a capability to manage CMC deliverables relevant to early-phase clinical development and on discovery programs with pre-clinical candidate compounds.
The qualified candidate must foster productive collaborations within the global Analytical R&D organization and with R&D cross-functional partners such as Discovery, Pre-Clinical Safety, Process Chemistry, Process Engineering, Molecular Profiling and Drug Delivery, Drug Product Development, and Quality Assurance and CMC-Regulatory.
The qualified candidate will be based at the AbbVie Bioresearch Center in Worcester, MA. However, they must be able to provide 50% on-site support at the AbbVie Bioresearch Center in Worcester, MA and 50% on-site support at the AbbVie Cambridge Crossing site in Cambridge, MA according to project needs.
Responsibilities:
- Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products to advise the selection of molecules with properties suitable for development.
- Generate new scientific proposals and lead those efforts. Anticipate and critically
evaluate scientific or regulatory advances or competitive threats and respond with
appropriate new strategies.
- Demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
- Embraces the ideas of others, nurtures innovation and manages innovation to reality.
- Raises the bar and is never satisfied with the status quo.
- Understand and comply with AbbVie safety, quality and regulatory policies and government regulations.
Qualifications
- Bachelors, Masters, or Ph.D. in Analytical Chemistry typically with a minimum of 14 (BS), 12 (MS), or 6 (Ph.D.) years related industry experience.
- Strong technical background in analytical chemistry, excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
- Demonstrated leadership with solving technical challenges across therapeutic modalities, specifically the lipid nanoparticle (LNP) and small molecule spaces.
- Demonstrated experience with a variety of mass spectrometry (MS) instrumentation and applications for structure elucidation and trace quantitation is highly desired.
- Fundamental understanding and working knowledge of various analytical techniques including HPLC, UPLC, GC, DSC, TGA, DVS, PXRD, NMR, dissolution.
- Familiarity with the role that physicochemical properties play in drug delivery and formulation design.
- Working knowledge of typical formulation approaches and routes of administration (i.e. IV, SC, IP, PO) across multiple species.
- Knowledge of preclinical and clinical formulation development principles relevant to lipid nanoparticle formulations.
- Demonstrate creative out-of-the-box thinking to solve difficult problems
- Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.
- High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our long-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
https://www.abbvie.com/join-us/reasonable-accommodations.html
Skills Required
- Bachelors, Masters, or PhD in Analytical Chemistry
- Minimum of 6-14 years of related industry experience
- Strong technical background in analytical chemistry
- Demonstrated leadership in solving technical challenges
- Experience with mass spectrometry and various analytical techniques
AbbVie Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about AbbVie and has not been reviewed or approved by AbbVie.
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Retirement Support — 401(k) contributions include a dollar-for-dollar match up to 6% plus an additional annual company contribution tied to age and service. Company-paid life insurance and other financial protections further strengthen long-term security.
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Parental & Family Support — Paid leave programs include up to 12 weeks at 100% for parental leave and separate paid caregiver leave, with eligibility after six months where noted. Adoption and surrogacy reimbursements and family-building resources add further support.
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Healthcare Strength — Health coverage begins on day one with medical, dental, vision, mental health, and prescription benefits, and preventive care covered at 100%. Options such as HSAs/FSAs and coverage for spouses/domestic partners and children up to age 26 broaden accessibility.
AbbVie Insights
What We Do
AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first — for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuroscience, eye care, aesthetics and other areas of unmet need.
