Principal Bioinformatics Scientist

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The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche. 

Roche Diagnostics is seeking a dedicated and motivated research scientist to join our computational biology research and early development team to contribute to early research and development of innovative next generation sequencing based  liquid biopsy diagnostic assays. The ideal candidate should have a strong background in bioinformatics, computational biology, or a related field, and will be instrumental in analyzing genomic data and developing algorithms to support the innovation and development of novel next generation sequencing workflows and their application in the translational setting towards innovative sequencing based liquid biopsy diagnostic solutions.

Join our growing team of talented research professionals! Elevate your career with unparalleled career development growth and skill enhancement.

The Opportunity:  

• Contribute to large interdisciplinary cross-organizational collaborations with global impact.

• Develop and apply computational tools for the analysis of high-throughput genomic, transcriptomic, and epigenetic data.

• Collaborate with experimental and computational researchers to design, analyze, and interpret molecular experiments.

• Work with next-generation sequencing (NGS) data including but not limited to RNA-Seq, ChIP-Seq, Methyl-Seq, Hybrid Capture and Whole Genome Sequencing.

• Use existing analytical tools and packages together with custom scripting and algorithm development to uncover insights from complex datasets.

• Prepare detailed reports and presentations of findings for stakeholders and team meetings.

• Support the maintenance and operation of bioinformatics infrastructure.

• Be part of a growing, hard-working and dynamic team and develop your career and upskill.

Who you are:  

• You bring a Master’s degree or PhD in Bioinformatics, Computational Biology, Statistics, Genetics, or a related field with over 5 years of proven experience working with raw NGS data types (FASTQ and BAM) from  genomic, Methyl-seq or ChIP-seq experiments..

• You are proficient in Python and Bash programming with demonstrated experience writing tools/algorithms to extract biological insights from mapped genomic sequence alignments.

• You have experience with bioinformatics programming tools and databases (e.g., Conda, GitHub, Bioconductor, Biopython, pysam, BLAST, BWA, SAMtools, BedTools, DeepTools, GATK, UCSC Genome Browser etc).

Preferred Qualifications

• Detailed understanding of molecular biology, genomic technologies, and their applications.

• Experience and in-depth knowledge of cancer biology and/or epigenetics.

• Proven analytical experience in ChIP-seq.

• Experience with machine learning and statistical data analysis.

• Demonstrated the ability to handle large datasets and computational workflows in high performance computing environments.

• Strong problem-solving skills and a collaborative mindset.

• Excellent written and verbal communication skills.

Relocation benefits are not available for this job posting. 

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Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche Pharma Canada has its office in Mississauga, Ontario and employs over 850 employees. The Mississauga facility is bright, vibrant, fosters collaboration and teamwork, and is reflective of Roche's truly innovative culture.