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Spring House, Pennsylvania, United States of AmericaJob Description:
About Innovative MedicineOur expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at https://www.jnj.com/innovative-medicine
We are searching for the best talent for a Postdoctoral Scholar, Bioanalytical Discovery & Development Sciences to be located in Spring House, PA.
Purpose: The Bioanalytical Discovery and Development Sciences (BDDS) department within Johnson & Johnson’s Preclinical Sciences & Translational Safety (PSTS) organization seeks a postdoctoral scholar to develop and validate an open, amplification-coupled immunoaffinity platform for reliable quantification of low-abundance protein biomarkers using standard laboratory equipment. The role addresses key analytical gaps in next-generation therapeutics by delivering fit-for-purpose assays, validation-ready documentation, and transferable methods to support PK/TE/biomarker decisions and translational studies.
This hands-on role includes assay and reagent design, systematic optimization, analytical characterization, benchmarking against orthogonal and commercial platforms, and preparation of SOPs and tech-transfer materials. The postdoc will collaborate with PK/PD and translational teams, communicate results through reports and publications, and help expand the use of ultrasensitive assays in preclinical and clinical programs.
- Leading the design, development, and optimization of ultra-sensitive, amplification coupled immunoaffinity assays to enable reliable quantification of low abundance biomarkers (targeting sensitivity down to fg/mL) using standard laboratory instrumentation.
- Leading head‑to‑head benchmarking of in‑house assays against orthogonal methods (LBA, LC‑MS) and commercial ultra‑sensitive platforms to compare LOD/LLOQ, precision, sample requirements, and tech‑transfer readiness.
- Collaborating with cross‑functional teams (PK/PD, bioinformatics, translational science, and external partners) to integrate biomarker data into study design and decision making, and to benchmark methods against orthogonal platforms.
- Producing and maintaining clear technical documentation, including Standard Operating Procedures (SOPs), reagent quality control (QC) criteria, validation plans/reports, and method transfer packages to support reproducibility and technology dissemination.
- Communicating findings through written reports, presentations, and contributions to manuscripts; providing training and technical support for method transfer and laboratory adoption.
Education:
- A PhD in Molecular Biology, Bioengineering, Biochemistry, Immunology, Analytical Chemistry, or a related field is required.
Required:
- Hands‑on experience developing and optimizing immunoassays or nucleic‑acid amplification assays (e.g., qPCR, digital PCR, NGS) is required.
- Practical knowledge of Immuno‑PCR, proximity ligation/extension strategies, or related amplification‑coupled immunoaffinity techniques is required.
- Strong molecular biology skills: PCR/qPCR assay design and optimization, UMI/barcode strategies, NGS library preparation workflows, template purification and contamination control is required.
- Excellent written and verbal communication skills are required.
- Ability to work in cross-functional teams and present technical results to diverse audiences is required.
- Familiarity with antibody/protein engineering, including optimizing affinity, stability, fragment design, and tagging, which directly enhances assay sensitivity and minimizes off-target binding is preferred.
- Prior experience measuring CNS biomarkers (e.g., tau species, neurodegeneration biomarkers) or working with low‑abundance protein analytes is preferred.
- Familiarity with bioanalytical platforms for ultrasensitive detection and an understanding of their strengths/limitations is preferred.
- Knowledge of PK/PD/TE study design as well as assay validation and how bioanalytical data informs translational decision making is preferred.
- Hands on experience with electronic lab notebook (ELN) systems and laboratory informatics platforms for experiment documentation, reagent/inventory tracking, and maintaining data integrity (e.g., commercial ELNs and signals style lab notebook systems) is preferred.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.
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Required Skills:
Preferred Skills:
Skills Required
- PhD in Molecular Biology, Bioengineering, Biochemistry, Immunology, Analytical Chemistry, or a related field
- Hands-on experience developing and optimizing immunoassays or nucleic-acid amplification assays
- Practical knowledge of Immuno-PCR or similar techniques
- Strong molecular biology skills in PCR/qPCR design and optimization
- Excellent written and verbal communication skills
- Ability to work in cross-functional teams
- Familiarity with antibody/protein engineering
- Prior experience measuring CNS biomarkers
- Knowledge of PK/PD/TE study design
Johnson & Johnson Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Johnson & Johnson and has not been reviewed or approved by Johnson & Johnson.
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Healthcare Strength — Healthcare coverage is characterized as comprehensive across medical, dental, and vision, with added supports like onsite clinics, fitness centers, and Employee Assistance resources. Mental-health services and wellbeing reimbursements are also described as meaningful components of the overall package.
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Retirement Support — Retirement offerings are portrayed as a major differentiator, combining a 401(k) with employer matching and an employer-funded pension plan. Stock options and other long-term financial supports are also positioned as part of the broader rewards mix.
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Parental & Family Support — Family-related benefits are presented as notably strong, including paid parental leave for all new parents and additional leave types for caregiving and bereavement. Financial assistance for adoption, fertility treatment, and surrogacy is highlighted as a significant support.
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