Lead HR Business Partner- US BioPharmaceuticals
Wilmington, DE
Human Resources
Hybrid Work- on average 3 days a week from office
The Lead HR Business Partner (HRBP) is a critical member of the US BioPharmaceuticals (US BBU) HR Leadership Team, accountable for shaping and delivering the people strategy that enables the Commercial business to achieve its ambitions. This role serves as a trusted advisor to senior leaders, translating business priorities into talent, organization, culture, and workforce strategies that drive sustainable performance.
The Lead HRBP has accountability for designing and implementing an integrated people strategy across an assigned client group, partnering closely with HR Centers of Excellence and HR colleagues to deliver exceptional employee and leadership experiences. The role combines strategic leadership, organizational effectiveness, talent development, workforce planning, change leadership, and coaching to ensure the business is equipped with the capabilities, leadership, and culture needed for future success. This role reports to the Vice President of HR, US BBU.
What you'll do
Contribute to the Commercial strategic workforce plan and the enterprise people and talent agenda through active participation on the US BBU HR Leadership Team.
Develop and execute an integrated people strategy aligned with the organization's vision, business priorities, and long-term objectives.
Serve as a trusted advisor to senior leaders, providing strategic counsel, challenge, and executive coaching to enhance leadership effectiveness and team performance.
Partner with HR Centers of Excellence to deliver effective and efficient solutions across talent management, rewards, performance, leadership development, employee experience, workforce planning, and recruitment.
Lead strategic talent reviews, succession planning, and leadership development efforts to build a strong and diverse pipeline of talent for current and future business needs.
Identify organizational capability gaps and design actionable organization, talent, and culture interventions that drive business performance.
Partner with leadership teams to shape organizational design, team effectiveness, and operating model decisions that support business transformation and growth.
Lead and support large-scale business change initiatives, ensuring thoughtful change management, stakeholder engagement, and adoption.
Use people analytics, workforce insights, and external trends to inform decision-making, identify opportunities, and measure the impact of HR strategies and interventions.
Apply foundational financial acumen including budgeting, FTE management, and facilitating demand planning activities to support the people agenda
Drive innovation and continuous improvement by leveraging digital technologies, AI, automation, and data-driven solutions to simplify processes, enhance the employee experience, improve decision-making, and create more efficient ways of working across the organization.
Essential for the role
Bachelor’s Degree in in Human Resources, Business, Psychology, or a related field
7+ years of HR experience within a large, sophisticated, and matrixed/global organization – preferably in HR client-facing role.
Digitally-savvy, with evidence of driving innovative solutions and a continuous improvement approach to HR implementation.
Demonstrable track record of leading the development and execution of HR and people strategies with measurable results.
Solid experience as a trusted advisor and coach to business leaders.
Excellent written and verbal communication skills, with the ability to influence, challenge, and negotiate at senior levels in an international environment.
Demonstrated use of HR analytics and organizational data to inform decision-making, develop interventions, and evaluate impact.
Desirable for the role
Master's degree
Project and change management experience
Leadership of teams and team effectiveness skills
Understanding of US employment law, policy, and risk management.
Office Working Requirements
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
#LI-Hybrid
Date Posted
21-Sept-2026Closing Date
04-Oct-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
Skills Required
- Bachelor's degree in Human Resources, Business, Psychology, or a related field
- 7+ years of HR experience in a large, sophisticated, matrixed, or global organization
- Experience in an HR client-facing role
- Digital proficiency and demonstrated experience driving innovative HR solutions and continuous improvement
- Track record of developing and executing HR and people strategies with measurable results
- Experience advising and coaching business leaders
- Excellent written and verbal communication skills, including the ability to influence, challenge, and negotiate at senior levels
- Experience using HR analytics and organizational data to inform decisions, develop interventions, and evaluate impact
- Master's degree
- Project and change management experience
- Leadership team and team effectiveness experience
- Understanding of US employment law, policy, and risk management
AstraZeneca Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about AstraZeneca and has not been reviewed or approved by AstraZeneca.
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Fair & Transparent Compensation — Pay is considered competitive across many roles when total rewards are factored in. Senior scientific and leadership bands are described with high ranges that reinforce competitiveness at upper levels.
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Strong & Reliable Incentives — Bonuses, equity eligibility in many salaried roles, and solid sales on‑target earnings with upside are emphasized as meaningful parts of compensation. These elements boost overall value even where base pay is not the very highest.
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Retirement Support — A 401(k) program with a strong company match and immediate vesting is repeatedly cited as a standout. Generous retirement support is viewed as enhancing the total package relative to peers.
AstraZeneca Insights
What We Do
We're transforming the future of healthcare by unlocking the power of what science can do for people, society and the planet.
