Job Description
Job Description
Vertex is seeking a highly motivated Senior Scientist, Immunology to join our research organization and contribute to the discovery and advancement of novel therapies for serious diseases. This individual will play an important role in designing and executing studies that deepen our understanding of immune mechanisms relevant to disease biology and therapeutic intervention.
The successful candidate will bring strong expertise in human primary immune cells, innate immunity, and macrophage biology, along with the scientific rigor and creativity needed to support research programs in a dynamic, collaborative environment. This role will work closely with cross-functional teams to generate high-quality data, guide scientific strategy, and help advance programs from early discovery through translational research activities.
This position is full-time on-site at the Vertex Leiden Center in Boston's Seaport district.
Key Duties and Responsibilities
- Design, execute, and interpret complex immunology studies to support discovery and translational research programs
- Lead experimental efforts focused on human innate immune function
- Apply deep scientific knowledge to investigate macrophage biology and its relevance to therapeutic hypotheses
- Generate high-quality, reproducible data and communicate findings clearly to cross-functional project teams and leadership
- Contribute to study design, data interpretation, and scientific decision-making across immunology-focused research initiatives
- Collaborate effectively with colleagues in immunology, pharmacology and related functions
- Maintain accurate documentation of experimental work and ensure results are analyzed and reported in a rigorous manner
- Identify emerging scientific opportunities and incorporate relevant advances in immunology into ongoing research strategies
- Contribute to a collaborative, high-performing research environment
Knowledge and Skills
- Deep understanding of immunology, with particular strength in innate immune mechanisms and cellular immune biology
- Strong scientific problem-solving skills and the ability to independently develop and test hypotheses
- Demonstrated ability to generate and analyze complex experimental results and translate findings into actionable scientific insights
- Excellent written and verbal communication skills, with the ability to present data effectively to multidisciplinary audiences
- Ability to work both independently and collaboratively in a fast-paced, matrixed research setting
- Strong organizational skills and the ability to manage multiple priorities while maintaining scientific quality
Education and Experience
- PhD in Immunology or a related relevant scientific discipline
- Significant relevant postdoctoral and/or industry experience in immunology research
- Demonstrated experience working with human primary immune cells
- Strong expertise in innate immunity and macrophage biology
- Proven track record of designing and executing independent research and contributing to team-based scientific programs
Pay Range:
$124,200 - $186,400Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
On-Site DesignatedFlex Eligibility Status:
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]
Skills Required
- PhD in Immunology or related discipline
- Significant relevant postdoctoral and/or industry experience in immunology research
- Demonstrated experience working with human primary immune cells
- Strong expertise in innate immunity and macrophage biology
- Proven track record designing and executing independent immunology research
- Ability to generate, analyze, and interpret complex experimental results and translate findings into actionable insights
- Excellent written and verbal communication skills and ability to present data to multidisciplinary audiences
- Ability to work on-site five days per week at Vertex Leiden Center in Boston
Vertex Pharmaceuticals Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Vertex Pharmaceuticals and has not been reviewed or approved by Vertex Pharmaceuticals.
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Parental & Family Support — Policies provide 12 weeks of 100% paid bonding leave for all U.S. parents with additional fully paid time for birth parents. Family-forming supports include adoption and surrogacy assistance, fertility options like IVF and egg cryopreservation, breast‑milk shipping, subsidized childcare, backup care, and a DCFSA match.
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Leave & Time Off Breadth — Time off includes roughly four weeks of vacation, 13 holidays, sick time, and two companywide shutdowns (summer and year‑end). Some roles also include flexible or unlimited time off and paid volunteer time.
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Retirement Support — Programs include a 401(k) plan with employer contributions and an employee stock purchase plan. Filings describe employer contributions occurring in company stock, supporting long‑term ownership.
Vertex Pharmaceuticals Insights
What We Do
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston’s Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 3,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry’s top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards.
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