Jobs at Vertex Pharmaceuticals

Lead design, optimization, and execution of high-parameter flow cytometry assays and multicolor immunophenotyping. Integrate cytometry with molecular profiling, analyze complex data to inform translational hypotheses, establish best practices, troubleshoot assays, mentor junior staff, and drive cytometry workstreams across discovery and development programs.

Lead design, execution, and optimization of spatial transcriptomics studies to characterize tissue architecture, cell interactions, and therapeutic response. Generate and integrate spatial data with single-cell, proteomic, imaging, and histologic datasets, develop robust sample and assay workflows, evaluate new spatial technologies, communicate findings, and mentor junior scientists to support discovery, translational, and biomarker programs.

Lead and manage deviation and QMS activities for internal cell & gene manufacturing. Oversee investigations (OOS/OOT), root cause analysis, CAPA, change control, and audit readiness. Provide on‑floor quality support, partner cross-functionally (Manufacturing, QC, MSAT, Supply Chain, Regulatory), drive continuous improvement, track metrics, and ensure regulatory compliance (cGMP, FDA/EMA) from startup through commercialization.

Develop and document combination drug-device products by authoring design history files, risk analyses (DFMEA/UFMEA/PFMEA), and design inputs/outputs. Support verification/validation, change control, deviations, and cross-functional investigations. Ensure alignment with cGxP, ISO 13485/14971, 21 C.F.R.820, and statistical requirements. Collaborate with R&D, QA/QC, regulatory, packaging, and manufacturing to enable process development and product transfer.

Lead QA support for Cell & Gene Therapy manufacturing across CDMOs, overseeing batch review, deviations, CAPA, change control, and QC release. Develop AI-enabled digitized solutions, metrics, dashboards, and records reconciliation (Python, Power BI, Smartsheet) to improve compliance, data integrity, and inspection readiness. Drive continuous improvement, audit readiness, and cross-functional quality projects.

Lead technology strategy and data roadmap for Commercial Cell & Gene Therapy. Act as primary DTE partner, prioritize and manage project portfolio, oversee large program delivery, and drive scalable, compliant AI and data-enabled solutions across cross-functional stakeholders to support global commercial operations.

The Territory Account Manager will build partnerships with healthcare customers, navigate complex health systems, develop account plans, facilitate access solutions, and drive business performance through strategic execution and collaboration.

The Territory Account Manager at Vertex builds relationships with healthcare stakeholders, develops account plans, and drives business performance in complex healthcare environments.

Future Territory Account Managers will establish partnerships with healthcare stakeholders, navigate health systems, and execute account plans to drive business performance and patient access effectively.

Lead and deliver cross-functional process improvement and transformation across Global Regulatory Affairs using operational excellence methodologies. Design, standardize, and implement scalable GRA processes, facilitate process mapping and root-cause analysis, deploy change management and training, create documentation and KPIs, and coach teams to increase efficiency, consistency, and quality. Partner with governance and senior leaders to align improvements with corporate priorities in a global, matrixed environment.

Lead AI and automation initiatives in Real-World Data analysis, optimize processes using AI/ML, and drive project management efficiency.

Responsible for building strategic partnerships with healthcare stakeholders, managing complex healthcare accounts, and executing account plans to enhance patient access. Collaborates across teams to drive business performance and ethical engagement.

Provide strategic QA oversight for GxP computer systems and QA-owned systems to support deployment of the Quality Management System. Lead information management strategy, ensure regulatory compliance and data integrity, drive computer systems quality and validation, partner across QA and third parties, and manage teams in a matrixed environment.

Develop and scale upstream and downstream processes for cell and gene therapy products. Perform stem cell expansion and differentiation in bench bioreactors, apply DoE/QbD for process characterization, transfer processes to manufacturing/CDMOs, execute experiments and data analysis, draft protocols and regulatory documentation, troubleshoot with quality tools (RCA/FMEA), and present technical findings to stakeholders.

Provide strategic FP&A leadership for biologics manufacturing and supply chain, lead budgeting/forecasting and long-range planning, develop COGS and manufacturing cost models, perform valuation and NPV analyses for major CapEx decisions, build automated dashboards and reporting, partner with accounting, DTE, and HR, and ensure financial governance and performance management across global operations.

Lead development and deployment of advanced data analytics, multivariate and machine learning models, and digital twin initiatives to characterize and improve pharmaceutical manufacturing processes. Collaborate across teams and partners, author technical documentation, support troubleshooting and quality investigations, and drive process monitoring, control strategies, and continuous improvement under cGMP.

Lead and execute risk-based internal audits, oversee portions of the SOX testing program, evaluate controls and risks, develop actionable recommendations, manage audit projects and third-party audits, contribute to audit strategy and reporting, coach junior staff, and improve audit practices including data analytics and trend reporting to enhance governance and control effectiveness.

The HR Business Partner Senior Director will lead HR initiatives in commercial business units, managing talent strategies, performance management, and organizational change, while working closely with senior leadership teams.

Lead and mentor a Technical Support team to enable technology transfer, process optimization, and lifecycle management for cell and gene therapy manufacturing. Oversee continuous improvement, equipment and process support, KPI-driven performance monitoring, deviation/CAPA/change control activities, and GMP documentation. Serve as escalation point for manufacturing issues, collaborate cross-functionally with Development, Quality, Supply Chain, and Operations, and ensure regulatory and quality compliance.

Lead analytical method lifecycle for late-stage and commercial biologics, including remediation, validation, transfer, troubleshooting, investigations, data trending, regulatory support for INDs/BLAs, authoring technical documents, and managing vendor/CMO partnerships to ensure cGMP compliance and analytical readiness for global commercialization.