Jobs at Vertex Pharmaceuticals

Leads user discovery and end-to-end UX design for AI-enabled commercial, medical affairs, and external affairs products. Conducts research, creates workflows, prototypes, and interface designs, and tests experiences with users across global markets. Partners with product, engineering, data science, and business teams to develop accessible, trustworthy, measurable AI experiences. Defines reusable design patterns and mechanisms for transparency, user control, feedback, escalation, and error recovery.

Provides independent, confidential administrative support to a Senior Vice President. Manages complex calendars, travel and meeting logistics, communications, documentation, invoices, contracts, visitor registration, onboarding, and cross-functional follow-up. Prepares meeting materials, improves administrative processes, handles sensitive information, and supports senior stakeholders. Also trains less experienced colleagues and prioritizes competing requests while maintaining high-quality service and organizational efficiency.

Leads category management and strategic sourcing for Commercial and Marketing categories. Develops sourcing strategies, conducts RFx activities and bid analysis, manages supplier relationships and performance, coordinates risk mitigation, and leads complex contract negotiations with cross-functional stakeholders. The role also supports end-to-end sourcing process optimization and business partner experience improvements.

Leads global portfolio and program management across the pharmaceutical drug development lifecycle. Directs cross-functional teams, integrated planning, governance, risk and issue resolution, strategic execution, process improvement, and stakeholder communication. Mentors senior professionals and managers while overseeing project deliverables, performance, resources, and potentially financial and personnel responsibilities. Requires extensive pharmaceutical development expertise and significant project and people management experience.

Leads R&D financial planning and analysis for Discovery Research and Preclinical Sciences. Partners with senior scientific leaders on budgeting, forecasting, scenario modeling, portfolio investment, resource allocation, reporting, controls, and research collaboration finances. Oversees AI-enabled finance transformation, dashboards, automation, and financial governance while managing two direct reports. Supports CRO and vendor spend, FTE planning, accounting processes, and executive decision-making across early-stage drug discovery portfolios.

Leads technical delivery and governance for Microsoft 365 Modern Work and enterprise AI platforms. Owns solution design, implementation, change control, automation, incident escalation, root cause analysis, documentation, and continuous improvement. Provides technical authority across Teams, SharePoint, OneDrive, Exchange, Copilot, Copilot Studio, GitHub Copilot, Power Platform, agents, and AI governance. Partners with business, security, privacy, legal, compliance, identity, vendors, and operations teams in a regulated enterprise environment.

Leads integrated customer experience activation strategy, translating customer journeys into digital capabilities, platform requirements, and business roadmaps. Owns website product strategy, marketing automation, customer data activation, orchestration, and agentic AI portfolios. Partners with technology and analytics teams to deliver scalable, governed, measurable engagement capabilities. Oversees vendors, leads cross-functional alignment, and manages and develops a team of 10 direct reports.

Acts as regional general counsel for Vertex’s CEEM operations, advising business leaders on regulatory, marketing, market access, pricing, reimbursement, supply chain, patient advocacy, safety, and government affairs matters. Drafts and negotiates access-program and commercial contracts, supports expansion into new therapy areas, manages legal staff, and provides strategic counsel across multiple countries. Requires substantial biopharmaceutical, law firm, or government legal experience, qualification to practice in a relevant country, and fluency in English and German.

Leads the architecture, development, and operation of Vertex’s enterprise agentic AI platform. Responsibilities include building RAG and knowledge retrieval systems, orchestration services, AI gateways, control towers, governance and guardrails, model routing, FinOps, observability, evaluation frameworks, and lifecycle management. The role defines technical standards and roadmaps, ensures scalability and security, partners across functions, evaluates emerging technologies, and mentors engineers while remaining hands-on.

Designs and delivers precision electromechanical and opto-mechanical scientific instruments from concept through deployment. Responsibilities include CAD and PDM design, manufacturability, documentation, procurement support, testing, integration, stakeholder collaboration, technical presentations, and mentoring. The role requires expertise in motion control, pneumatics, fluidics, enclosures, manufacturing processes, and production-ready machine design. This is an onsite position supporting Vertex’s drug discovery research in San Diego.

Leads supply chain analytics and reporting initiatives from requirements gathering through implementation and continuous improvement. Partners with Finance, Quality, Data & Technology, and supply chain stakeholders to define KPIs, govern metrics, resolve data quality issues, and deliver scalable dashboards and reports. Analyzes inventory and supply chain data to identify trends, inefficiencies, and improvement opportunities. Requires strong supply chain planning knowledge, experience with MRP systems, inventory tracking, CMO planning, and cross-functional project leadership.

Build and support secure, scalable Microsoft Azure infrastructure for enterprise, data, and AI applications. Develop CI/CD pipelines, infrastructure-as-code solutions, cloud security controls, deployment automation, monitoring, and observability. Troubleshoot infrastructure and deployment issues, perform root-cause analysis, and partner with engineering, security, architecture, and business teams to improve cloud-native delivery and platform reliability. The role also supports Azure AI and Microsoft Foundry capabilities.

Leads commercial data governance strategy, operating models, policies, standards, ownership, stewardship, metadata, lineage, and data-quality programs. Partners with cross-functional stakeholders to improve data integrity, accessibility, privacy, compliance, and responsible use. Oversees governance councils, catalogs, glossaries, issue remediation, performance metrics, tool adoption, training, and change management across a regulated biotechnology commercial organization.

Leads revenue accounting for distributor markets, including month-end close, revenue recognition, gross-to-net accounting, reconciliations, reporting, compliance, audits, and SOX controls. Evaluates contracts and reimbursement arrangements under US GAAP and ASC 606, resolves variances, partners with cross-functional stakeholders, coaches junior staff, and drives process automation and reporting improvements.

Leads technology-enabled transformation initiatives across Medical Writing Science, translating business needs into requirements, process designs, implementation plans, testing, and adoption activities. Coordinates stakeholders, milestones, risks, and dependencies while facilitating prototypes, pilots, user acceptance testing, change management, training, and continuous improvement. Evaluates AI, automation, analytics, and digital capabilities to improve scientific and operational workflows.

Leads a portfolio of complex, technology-enabled transformation initiatives within Medical Writing Science. Translates strategic priorities into executable programs, manages dependencies, risks, resources, governance, and trade-offs, and drives implementation, adoption, and value realization. Partners with scientific, business, and technology stakeholders on AI, analytics, automation, and digital workflows while overseeing responsible AI, organizational readiness, change management, and cross-functional team development.

Leads complex technology-enabled transformation initiatives across Medical Writing Science, from business needs and workflow redesign through solution evaluation, implementation, adoption, and optimization. Develops business cases, requirements, success measures, and implementation approaches; evaluates prototypes and pilots; manages risks, dependencies, governance, responsible AI, compliance, and stakeholder alignment. Partners with scientific, business, technology, and change teams to deliver measurable outcomes in a regulated life sciences environment.

Leads global pharmaceutical logistics operations for small-molecule and biologics products, including temperature-controlled shipments, site-to-site movement, 3PL and carrier management, import/export compliance, and distribution. Develops logistics network strategies, oversees logistics service providers, manages continuous improvement and cross-functional projects, supports product launches, and ensures Good Distribution Practice compliance across internal, external, and contract manufacturing networks.

Owns the Source-to-Pay data and analytics foundation, including master data, taxonomy, governance, quality, analytics products, automation, and AI readiness. Leads business requirements, operating models, executive dashboards, KPI frameworks, decision-support insights, and cross-functional platform enablement. Partners with Procurement, Finance, Legal, Risk, IT, and enterprise data teams to improve data reliability, controls, reporting, self-service analytics, and scalable automation.

Manages financial planning, budgeting, forecasting, long-range planning, and performance analysis for clinical development functions. Builds financial models, analytics, reporting, scenarios, and business cases to support investment decisions and identify risks and opportunities. Partners with clinical and finance leaders, drives process improvement across the CFO organization, and provides financial insight to guide business decisions.