Genomics Data Operations Engineer

Posted 5 Days Ago
Be an Early Applicant
2 Locations
Hybrid
Mid level
Biotech
The Role
Ingest, transform, harmonise and quality-control large genomic datasets (GWAS, genotypes, phenotypes). Configure pipelines, interpret QC diagnostics, investigate anomalies, curate metadata, and collaborate with engineering and science teams to expand genomic data resources and schemas.
Summary Generated by Built In

Location: Oxford or London (Hybrid)

The Mission: Why We Exist

Genomics is a science-led transatlantic TechBio combining large-scale genetic and health data with proprietary analytics to accelerate drug discovery and advance predictive, preventative healthcare. We are united by a single vision to help people live longer healthier lives, using the power of genomics.

Genomics aims to help people live longer, healthier lives in two ways: super-charging drug discovery and development for novel treatments with our AI-enabled advanced genetic analytics platform, and by helping people understand their personal risk of common chronic diseases through polygenic risk scores - giving doctors and health systems the chance to get the right people into the right prevention, screening and treatment programmes at the right time.

Role Purpose

Data is the foundation of everything we do. Our Data Engineering team owns the end-to-end journey of the genomic datasets that power both our commercial products and our internal science – from disease-risk insights that reach real patients, to the discovery of novel therapeutic targets.

As a Data Engineer in this small, high-impact team, you'll turn large, complex and scientifically consequential datasets into trusted, analysis-ready resources. Your focus will be data transformation, harmonisation and quality control: working within established automated workflows, but bringing the statistical-genetics judgement to know when the numbers don't add up – and the curiosity to find out why.

As you grow, you'll take on broader work – helping define schemas for new data types and shaping how we expand our genomic data resource. It's a genuine intersection of data engineering, data modelling and genetics, with real scope to develop across both technical and scientific dimensions.

A Day in the Life

  • Moving data in: ingesting large-scale genetic and genomic datasets – GWAS summary statistics, individual-level genotype and phenotype data – through a mix of scripting, automated pipelines and hands-on processing in a Linux environment.

  • Safeguarding quality: interpreting QC metrics and diagnostic plots, investigating anomalies, and applying sound scientific judgement to resolve data-quality issues.

  • Getting the detail right: configuring workflow parameters and curating dataset metadata so every dataset is correctly represented, fit for scientific use, and clearly described for internal scientists and external customers.

  • Collaborating: partnering with software engineers and developers in an agile setting to diagnose pipeline issues, define requirements and continuously improve our ingestion and QC processes.

  • Growing: contributing to schema design for new data types and helping expand our genomic data resource alongside science, product and engineering.

Who You Are

  • Grounded in human statistical genetics, with hands-on experience of GWAS summary statistics and/or large-scale individual-level genotype and phenotype data.

  • Proficient in Python and Unix/Linux, and able to point to real bioinformatics or data-engineering work in a research or commercial setting.

  • Confident reading complex data-quality outputs, and able to use scientific judgement to investigate and resolve issues.

  • Well organised – happy to plan, prioritise and deliver across competing tasks at pace.

  • A strong communicator who works well across multi-disciplinary teams and just as effectively on your own.

  • Educated to BSc or higher in a relevant discipline – bioinformatics, computational biology, human genetics or similar – or with equivalent experience

Your Package

We are committed to providing a transparent, supportive, and rewarding work environment.

Compensation & Growth
  • Competitive Salary: Salaries are externally benchmarked annually to ensure top-of-market compensation.

  • Clear Career Path: A straightforward, open progression framework means you'll always know the path to promotion and how to achieve your next career goal.

  • Continuous Learning: Including external courses and a wide library of L&D materials, because your growth is our success.

Wellbeing & Time Off
  • Holiday: 25 days annual leave, plus bank holidays, plus an extra 3-day company-wide shutdown at year-end.

  • Financial & Health Security: Robust benefits including a market-leading pension scheme, comprehensive private health insurance for you and your family with NO excess, critical illness, and life assurance.

  • Enhanced Leave: Enhanced paid family leave to support all new parents.

Work Environment & Culture
  • Flexible Working: Hybrid Working (e.g., From our London, Oxford Office)

  • Truly Inclusive Time Off: Our 'Bank Your Bank Holiday' program allows you to exchange public holidays for dates that hold personal or cultural significance to you.

  • Vibrant Social Culture: From regular Town Halls and team picnics to organised sports events, our social committee ensures frequent opportunities to connect and celebrate.

  • Green Commute: Cycle-to-Work scheme and convenient office locations near major transport hubs.

Ready to Build the Future?

If this opportunity excites you, apply now!

We are dedicated to creating a diverse environment and are proud to be an equal-opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

Genomics politely requests no contact from recruitment agencies. We do not accept speculative CVs from recruitment agencies nor accept the fees associated with them.

Skills Required

  • Hands-on experience with GWAS summary statistics and/or large-scale individual-level genotype and phenotype data
  • Grounding in human statistical genetics
  • Proficiency in Python
  • Proficiency in Unix/Linux and experience working in a Linux environment
  • Experience with scripting and automated data ingestion pipelines / bioinformatics workflows
  • Ability to interpret QC metrics and diagnostic plots and apply scientific judgement to resolve data-quality issues
  • Experience working in research or commercial settings with bioinformatics or data-engineering projects
  • BSc or higher in bioinformatics, computational biology, human genetics, or equivalent experience
  • Strong communication and the ability to collaborate across multidisciplinary teams
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The Company
HQ: Oxford
164 Employees
Year Founded: 2014

What We Do

We are a pioneering healthcare company that aims to transform health through the power of genomics. The company was formed in 2014 by four world-leading statistical and human geneticists at the University of Oxford, including Professor Sir Peter Donnelly and Professor Gil McVean. We use large-scale genetic information to realise preventative medicine and improve drug discovery. We're a world-leader in genomic prevention: a paradigm-changing approach to sustainable healthcare which for the first time allows reliable, personalised estimates of risk for all the common diseases and cancers, well ahead of disease manifestation, allowing accurate and early interventions and tailored screening. Our proprietary algorithms and databases offer something no competitor can: the ability to accurately link minute variation across the entire genome to changes in thousands of biological measurements and disease outcomes, to generate population-level insights for healthcare systems, individual-level insights for clinicians about the risk of common diseases, and new understanding of disease processes. In August 2018, we announced a multi-year collaboration with Vertex to use human genetics and data science to advance discovery of precision medicines. We also have several pilot programmes in development within UK and US healthcare systems. Our team is a multi-disciplinary group focused on finding powerful and creative solutions for bringing subject-leading science to as wide an audience as possible, and, in doing so, offer the chance of transforming lives around the world. The workforce is highly qualified and consists of over 150 people, including genomic scientists, computational biologists, statisticians, software engineers, product developers, data scientists and commercial strategists. We are headquartered in Oxford, with offices in Cambridge (UK), London (UK), and Boston (US).

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