Director or Sr. Director, DMPK

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

You will be accountable to set DMPK strategy and drive execution to advance projects from early discovery through preclinical development, and will seamlessly partner with all line functions represented on project teams. Your deep expertise in PK/ADME strategies and tactics in beyond Ro5 small molecule drug discovery and preclinical development is foundational, as is hands-on experiences in PK and PK/PD modeling, and human PK, dose, and DDI predictions. You will thrive in a collaborative, past-paced, interdisciplinary team environment.

• Represent DMPK function as core project team member across multiple high profile programs in our Immunology franchise. Accountability for all aspects of DMPK support. Planning, stewardship, analysis, and integration of all in In Vitro and In Vivo ADME, PK, and PK/PD efforts in support of discovery and preclinical development programs.
• Outstanding, proactive collaboration with all team functions (Pharmacology, Toxicology, Pharm. Sci., Form. Dev., Chemistry, Translational Medicine, Clin. Pharm.) to secure effective advancement of Kymera’s projects and portfolio. Influence wider project strategy and team decision making.
• Conduct PK and PK/PD modeling, provide predicted human PK and efficacious dose projections and DDI risk assessment.
• Design and implementation of DMPK strategies for NCE optimization and characterization in collaboration with PCD peers, and project and other functional stakeholders.
• Manage interactions with CROs to ensure high quality and on-time execution of DMPK studies.
• Author and review relevant sections of regulatory documents.
• Contribute to Kymera’s internal and external presentation/publication strategy.

• MSc or PhD in Drug Metabolism, Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, or related disciplines.
• 15+ years (with MSc) or at least 10 years (with PhD) of relevant experience in the Pharmaceutical/Biotech industry.
• Prior experience as a core DMPK project team representative on a multifunctional team is critically required, previous supervisory/managerial experience of DMPK project representatives and/or accountability for DMPK on a project portfolio is ideal.
• In-depth understanding and strategic application of all PK/ADME assays, methods and models. Ability to distill critical information, develop structure-property relationships, clear strategic guidance & effective communication in support of effective multi-parametric NCE optimization.
• Strong understanding of DMPK, PK/PD modeling, human PK, efficacious dose, and DDI prediction strategies, incl. all required input from adjacent functions.
• Expertise in managing CROs, robust knowledge of relevant regulatory guidances.
• Proficiency in Phoenix WinNonlin desired. Experiences with PBPK modeling are a plus.
• Passion for data driven analysis, and strongly developed business-of-science thinking.
• Excellence in analytical, organizational, and communication skills.
• Ability to thrive in a fast-paced, highly matrixed environment.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $195,000 – $330,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.