Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
The Director, Externally Sponsored Research (ESR) (including investigator sponsored trials and collaborative research) will lead the strategy, oversight, and execution of Revolution Medicines' ESR processes within one of our disease areas. This role will ensure scientific rigor, compliance, and alignment of the ESR program with company and external regulatory guidelines. The individual will collaborate closely with internal and external stakeholders to drive excellence in external research. Specifically, this individual will partner with Medical Strategy, Clinical Operations, and others on strategic development and execution of the program. The opportunity involves leadership of ESR-specific scientific committees and broad visibility within the organization. The Director, ESR, reports to the head of the ESR program.
Externally Sponsored Research Program Leadership
Oversee the end-to-end ESR process for a specific disease area, including development of areas of interest, proposal review, approval, funding, and execution.
Help set scientific and strategic objectives and ensure that ESRs align.
Represent ESR program within the organization.
Lead cross-functional scientific committees in proposal and protocol reviews.
Maintain compliance with regulatory and legal requirements.
Monitor ongoing ESRs progress, ensuring milestone tracking, study reporting, and data dissemination.
Optimize ESR program scalability and operational efficiency, including systematic tracking of proposals, funding allocations, and study outcomes.
Will directly supervise the ESR manager assigned to the program.
Cross-Functional & External Stakeholder Collaboration
Serve as a key point of contact for ESR-related interactions with internal and external stakeholders.
Partner with Clinical Operations on execution of the ESR program, including contracting, budgets, enrollment, and metrics.
Work closely with Medical Affairs, Clinical Development, Preclinical, and other teams to align ESR funding with strategic priorities.
Build relationships with external medical and scientific communities, including external investigators, KOLs, and cooperative groups.
Ensure timely and transparent communication with investigators, maintaining strong external partnerships.
Required Skills, Experience and Education:
Advanced scientific or medical degree (PhD, PharmD, MD).
10+ years of experience in Medical Affairs and ESRs within the biotechnology or pharmaceutical industry.
Proven ability to develop and execute medical research strategies aligned with company and scientific priorities.
Experience in ESR program leadership, including proposal review, funding allocation, and study execution.
Ability to navigate cross-functional partnerships with Legal, Compliance, Regulatory, and Clinical teams.
Strong analytical and strategic thinking skills with the ability to assess research proposals for scientific merit and alignment.
Excellent communication, interpersonal, and presentation skills to engage internal and external stakeholders effectively.
Deep knowledge of global regulatory requirements for Medical Affairs, including FDA, EMA, ICH, GVP, and industry best practices.
Preferred Skills:
Prior experience in oncology, precision medicine, or targeted therapies.
Familiarity with digital tools and platforms for grant submissions and ESR management.
#LI-Hybrid #LI-YG1
The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.
Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [email protected].
We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.
Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.
If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.
Skills Required
- Advanced scientific or medical degree (PhD, PharmD, MD)
- 10+ years of experience in Medical Affairs and externally sponsored research within biotech or pharmaceutical industry
- Proven ability to develop and execute medical research strategies aligned with company and scientific priorities
- Experience leading ESR programs including proposal review, funding allocation, and study execution
- Ability to navigate cross-functional partnerships with Legal, Compliance, Regulatory, and Clinical teams
- Strong analytical and strategic thinking skills to assess scientific merit and alignment
- Excellent communication, interpersonal, and presentation skills for internal and external engagement
- Deep knowledge of global regulatory requirements (FDA, EMA, ICH, GVP) and industry best practices
- Prior experience in oncology, precision medicine, or targeted therapies
- Familiarity with digital tools and platforms for grant submissions and ESR management
What We Do
We are Revolutionaries – passionate in our singular pursuit of discovering, developing and delivering innovative, targeted medicines for patients living with cancer. To deliver on our vision, we work relentlessly in pursuit of cutting-edge therapeutic approaches to some of the toughest cancers. Our current focus is on RAS-addicted cancers, which account for 30 percent of all new human cancer diagnoses
