At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.
Job Summary:
As a Research Associate II, Analytical Development, you will participate in activities to support the development and testing of analytical methods in support of process development, release, stability and characterization assays for Fc-fusion molecules.
Primary Responsibilities:
- Assist in the development of chromatography and electrophoresis based analytical methods to be used for product release, stability, and characterization testing
- Prioritize and perform timely testing that enables process and MSAT teams to meet project timelines. This will require occasional weekend work initially.
- Critically evaluate analytical data to support method development decisions and product quality comparisons
- Maintain accurate and timely experiment records in electronic laboratory notebook (ELN)
- Summarize and present data in a clear and meaningful way
- Author and review analytical test methods and development reports
- Participate in team meetings with external testing labs
- Participate in laboratory organization activities such as ordering and receipt of reagents and samples
Qualifications:
- B.S. or M.S. in Analytical Chemistry, Biochemistry, Chemical Engineering, Pharmaceutical Sciences or related scientific discipline with a minimum of 1-3 years of CMC analytical development experience in biotech/pharma
- Hands-on experience with various analytical methods for measuring the purity of biologics and residual process impurities (i.e. chromatography, capillary electrophoresis, ELISA, etc.)
- Experience with chromatography and capillary electrophoresis data analysis software
- Excellent laboratory, critical thinking, scientific problem-solving, and organizational skills
- Familiarity with good documentation requirements and industry guidance
- Knowledge of statistical approaches for data interpretation and analytical method development
- Motivated, detail-oriented, naturally curious individual with a creative approach to scientific problem solving
- Excellent spoken and written communication skills
This pay range represents the base hourly rate or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, and other relevant factors.
Our Diversity, Equity & Inclusion Mission Statement: Keros is an inclusive company. We believe that diversity drives innovation. We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees. As such, Keros takes a holistic approach in mentoring, coaching, and developing all of our Keros team members.
Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.
Recruitment & Staffing Agencies:
Keros Therapeutics does not accept unsolicited resumes from any source other than the candidate directly. Any unsolicited submission by an agency to Keros is prohibited. Any resume submitted by an agency without a signed contract or expressed consent by a member of the Keros Therapeutics Human Resources Department, will be considered property of Keros Therapeutics, and no fee shall be owed with respect thereto.
Skills Required
- B.S. or M.S. in Analytical Chemistry, Biochemistry, Chemical Engineering, Pharmaceutical Sciences or related discipline with 1-3 years CMC analytical development experience in biotech/pharma
- Hands-on experience with analytical methods for biologics purity and residual process impurities (chromatography, capillary electrophoresis, ELISA)
- Experience with chromatography and capillary electrophoresis data analysis software
- Experience using an electronic laboratory notebook (ELN) and maintaining accurate experiment records
- Familiarity with good documentation practices and industry guidance
- Knowledge of statistical approaches for data interpretation and analytical method development
- Excellent laboratory, critical thinking, scientific problem-solving, and organizational skills
- Excellent spoken and written communication skills
- Motivated, detail-oriented, naturally curious with a creative approach to scientific problem solving
What We Do
Keros is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel treatments for patients suffering from rare hematologic and musculoskeletal disorders with high unmet medical need
