Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).
Benefits We Offer:
- 100% Medical, Dental & Vision Coverage for Employees
- Paid Time Off and Paid Holidays
- 401K match up to 5%
- Educational Benefits for Career Growth
- Employee Referral Bonus
- Flexible Spending Accounts:
- Healthcare (FSA)
- Parking Reimbursement Account (PRK)
- Dependent Care Assistant Program (DCAP)
- Transportation Reimbursement Account (TRN)
Position Overview
The Bioinformatics / Data Scientist will conduct comprehensive analyses of multi-omics data generated from organoid systems and corresponding normal tissues. The position is central to the SOM Center’s research objectives, focusing on characterizing organoid fidelity, identifying biomarkers of successful differentiation, and developing computational frameworks for organoid quality assessment.
Key Responsibilities
Multi-omics analysis. Analyze complex datasets including single-cell RNA sequencing, bulk RNA sequencing, proteomics, and metabolomics data from a range of organoid systems and their tissue counterparts.
Experimental design consultation: Collaborate with experimental wet-lab on experimental design to better optimize protocols for knowledge discovery and performance.
Pipeline development. Develop and implement computational pipelines for data processing, quality control, and statistical analysis.
Benchmarking. Integrate SOM-generated data with publicly available datasets in order to benchmark organoid characteristics against normal tissue profiles.
Collaboration and interpretation. Work closely with experimental teams to interpret results and guide protocol optimization.
Dissemination. Contribute to manuscript preparation and present findings at scientific conferences.
Required Qualifications
Education. Doctoral degree (PhD) in bioinformatics, computational biology, biostatistics, or a related quantitative field.
Single-cell analysis. Extensive experience with single-cell data analysis, including familiarity with tools such as Seurat, Scanpy, or comparable platforms.
Programming. Strong programming proficiency in R and Python, together with experience in statistical analysis and data visualization.
Omics workflows. Basic knowledge of proteomics and metabolomics data.
Preferred Qualifications
Prior experience analyzing organoid datasets.
Experience with machine learning approaches for biological data, familiarity with pathway analysis tools, and knowledge of developmental biology principles.
Experience with high-performance computing environments and version control systems.
Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.
Accessibility: If you need an accommodation as part of the employment process please contact: [email protected]
This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.
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Skills Required
- Doctoral degree in bioinformatics, computational biology, biostatistics, or a related quantitative field
- Extensive experience with single-cell data analysis
- Familiarity with Seurat, Scanpy, or comparable single-cell analysis platforms
- Strong programming proficiency in R and Python
- Experience with statistical analysis and data visualization
- Basic knowledge of proteomics and metabolomics data
- Experience analyzing organoid datasets
- Experience with machine learning approaches for biological data
- Familiarity with pathway analysis tools
- Knowledge of developmental biology principles
- Experience with high-performance computing environments
- Knowledge of version control systems
What We Do
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, health informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we develop and apply research tools and techniques that empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH) by offering the responsiveness of a small business coupled with the experience, breadth, and depth of a large organization.
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