Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead is seeking a highly motivated molecular biologist to join our growing Bioassays team at our Madison site. The Molecular Biology team supports R&D projects across all sites. The ideal candidate should have 1-2 years of cloning experience with the ability to independently work on multiple constructs simultaneously.
Responsibilities
- Support in vitro, ex vivo and/or in vivo studies to facilitate drug discovery and development with some independence
- Propose methods and ways to optimize cloning
- Occasionally present research findings to project teams
- Occasionally read relevant scientific literature and propose applications to projects to troubleshoot and solve problems
- Maintain a high level of productivity and quality in the lab
- Perform critical experiments
- Primary Molecular Biology Responsibilities:
- Clone plasmid constructs by various methods (Digest/ligation, IVA)
- Perform large-scale plasmid preps
- Autoclave glassware and media
- Manage lab inventory and assist in ordering
- Project documentation
- Work with a small team of scientists, while working closely with other research groups and senior managers
Requirements
- Bachelor of Science in Biology or related field
- 3+ years of experience in cell biology, molecular biology, immunology, pharmacology or a related field of biology
- 2+ years experience with methods and technologies involving plasmid cloning, AAV packaging, protein expression vectors
- Experience in standard cellular and molecular biology techniques (PCR, Digestion, Ligation, Transformation, DNA isolation)
- Experience in standard microbiology techniques (Bacterial cultures, Autoclaving, Preparing Media)
- Experience with Benchling and Snapgene
- Demonstrated innovation, creativity and resilience in problem solving
- Excellent oral and written communication skills
- Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environment
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
California Applicant Privacy Policy
Similar Jobs
What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients. Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety. Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline. Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations. Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
