Jobs at Helix

Leads development, validation, maintenance, and documentation of clinical bioinformatics pipelines for high-volume patient sequencing data. Evaluates and triages data supporting clinical variant calls, oversees bioinformatics operations and metrics, and collaborates with engineering, laboratory, quality, and clinical teams to launch genomic products. Requires hands-on DNA sequencing analysis, Python coding or data analysis, and experience in clinical genomics or regulated environments is advantageous.

Leads Helix’s pharmacogenomics business, setting growth strategy, developing ROI models, engaging health system and health plan executives, shaping EHR-embedded clinical decision-support products, and building go-to-market strategies. The role translates clinical and customer needs into product priorities, partnerships, and scalable PGx adoption programs while tracking guidelines, reimbursement, and market developments.

Designs, implements, and owns reliable software systems across patient, laboratory, data, and genomics platforms. Leads projects from scoping through launch, uses AI agents and coding harnesses, improves engineering standards, mentors engineers, addresses technical debt, and collaborates cross-functionally. The role requires cloud-based distributed systems expertise, strong programming skills, infrastructure-as-code familiarity, database knowledge, testing, CI/CD, observability, and independent product-focused execution.

Design, build, deploy, and operate scalable full-stack, cloud-native software and infrastructure for clinicogenomic data products. Responsibilities include distributed systems, Kubernetes, serverless services, event-driven architecture, CI/CD, infrastructure as code, technical direction, engineering standards, AI-assisted development, cross-functional collaboration, and mentoring.

Leads technical direction for Helix’s Experience platform, designing and implementing genomic software systems focused on patient and provider experiences. Drives AI adoption across engineering, including automated workflows, safeguards, and evaluations. Owns complex projects from scoping through production, establishes engineering standards, mentors technical leaders, improves reliability, and collaborates with product, design, research, science, and business teams.

Sets technical direction for Helix’s Experience platform and broader engineering organization. Designs and implements distributed, full-stack genomic software systems focused on patient and provider experiences. Leads complex projects from scoping through production, advances AI-assisted engineering practices, establishes quality and delivery standards, mentors technical leaders, and drives cross-functional collaboration with product, design, research, scientific, and business teams.

Develop and evaluate machine learning and generative AI models using linked genomic and clinical data. Build LLM agentic systems, clinical variant interpretation pipelines, genomic representations, and reliable evaluation workflows. Investigate healthcare data quality, present findings, collaborate with bioinformatics and clinical teams, and contribute to scientific publications. The role requires strong Python, statistics, experimentation, cloud GPU, and software engineering practices, plus interest in biology and precision medicine.

Develop and maintain reliable software across laboratory systems and enterprise AI tooling. Responsibilities include building features, fixing bugs, writing tested code, reviewing AI-generated code, integrating APIs and databases, collaborating with product and stakeholders, and learning Helix’s cloud infrastructure and genomics-related domain. Engineers progressively take ownership of projects while working with AI coding agents as part of the standard development workflow.

Manage Helix’s legal operations infrastructure, including request intake, workflows, SOPs, legal technology platforms, metrics, contract reviews, renewals, vendor coordination, outside counsel, IP docketing, and corporate filings. The role partners cross-functionally with legal, finance, procurement, and business leaders to improve processes, administer systems, triage matters, and maintain efficient, organized legal operations.

Owns customer success and strategic partner relationships for Helix’s life sciences data licensing, sponsored testing, and clinical development businesses. The role leads implementation coordination, identifies expansion opportunities, translates customer feedback into product improvements, establishes scalable customer success processes, mentors team members, and represents the function in leadership discussions. Candidates must bring extensive biopharma or life sciences partnership experience, people leadership, strong communication, and demonstrated use of AI tools to improve productivity and business outcomes.

Support health system and life sciences research partners using Helix’s clinico-genomic datasets, tools, and platforms. Serve as the primary data-support contact, lead onboarding and office hours, create user materials, coordinate internal technical support, gather feedback, and help refine solutions. Build clinical and genomic data-processing pipelines while collaborating with Engineering, Research, Bioinformatics, Product, Life Sciences, and Commercial teams.

Perform on-site pre-analytical laboratory tasks in a high-volume CAP/CLIA facility: build and ship at-home kits (~20%), receive/unpack/accession specimens, perform data entry and plating, operate automated equipment, maintain biohazardous waste compliance, track inventory, and coordinate handoffs. Follow protocols, ensure sample integrity, and support process improvements and training as you advance.

Drive adoption of Helix genomic diagnostic testing services by developing regional sales strategies, building healthcare provider relationships, managing partner planning, presenting diagnostic solutions, maintaining CRM pipeline forecasts, and achieving sales targets. The role requires extensive customer-facing diagnostics experience, genomics industry knowledge, strong communication and analytical skills, and 60% travel.

Process and verify vendor invoices through procurement software, maintain vendor master data, manage vendor correspondence, reconcile statements, assist with month-end accruals and 1099s, support prepaids and fixed asset accounting, and collaborate cross-functionally to improve AP processes and leverage AI tools for efficiency.

Drive adoption of Helix diagnostics by building and executing account strategies, cultivating relationships with key partner personnel, managing CRM sales pipeline and forecasts, meeting sales targets, developing strategic presentations, and supporting partner planning. Role requires frequent travel and independent, data-driven execution.