Jobs at Calico Life Sciences

Leads DMPK strategy for drug discovery and development programs, providing expert guidance to cross-functional teams. Designs, coordinates, analyzes, and interprets in vitro and in vivo studies; manages CROs and external partners; oversees data quality and delivery; and authors DMPK reports, regulatory documents, and publications. Collaborates with biology, chemistry, project teams, and external stakeholders to support candidate selection and development decisions.

Lead drafting, negotiation, and management of research and development agreements, including sponsored research, licenses, confidentiality, material transfer, manufacturing, consulting, and services contracts. Serve as the business and contracts liaison for scientific collaborations, coordinate with legal and IP counsel, manage partner commitments and approvals, and improve contract templates and workflows. Collaborate with leadership, R&D, finance, CMC, alliance management, and project teams to support life sciences programs.

Lead controllership and accounting operations, manage monthly/quarterly/annual close, oversee clinical trial accruals, ensure US GAAP and SOX compliance, mentor accounting staff, optimize processes and automation (Excel-to-NetSuite) and partner with cross-functional teams.

The role involves designing and training deep learning models for genomic analysis, collaborating with scientists, and publishing research findings.

Build and scale end-to-end ML platforms and generative modeling tools for molecular design. Own data ingestion, training, evaluation, serving, and reproducibility; optimize accelerator utilization; automate ML-to-wet-lab workflows; prototype and deploy models to accelerate drug discovery.

The Associate Director of External Communications will develop and execute strategies to enhance Calico's brand presence and communicate scientific advancements through various channels while managing media inquiries and collaborating with cross-functional teams.

Lead design and operation of a next-generation ML platform on GCP: build IaC, centralize projects into a compliant landing zone, administer GKE clusters for distributed ML, automate identity and guardrails with Terraform, optimize GPU/TPU compute and costs, and create developer onboarding and paved paths for scientists.

The Principal Scientist will bridge computational design and experimental validation in antibody discovery, leading projects and ensuring rigorous validation of computational predictions.