With its strong ties to the Research Triangle, Raleigh is unsurprisingly a top city for tech startups. With its academic standing and thriving economy, the city has created its own multi-faceted tech ecosystem, composed of many up-and-coming startups. While one is working at the cutting-edge of artificial intelligence, another as advancing cancer care.
For these Raleigh startups, discovering groundbreaking approaches to everyday problems is key to turning the city into a top tech hub.
Raleigh-Based Startups to Know
- Click Therapeutics
- Flatiron Health
- Liine
- Allstacks
- Policygenius
Top Startups in Raleigh
Founded: 2017
Focus: AI and Enterprise Augmented Intelligence
What it does: Pryon is an AI memory platform that connects enterprise data sources — such as PDFs, spreadsheets and other internal documents — to AI applications. It processes and indexes this structured and unstructured information so organizations can run secure search platforms, interactive assistants and automated workflows grounded in their proprietary data.
Founded: 2014
Focus: Insurance
What it does: Policygenius is an online insurance marketplace and brokerage platform that allows consumers to compare and buy life, home, auto and disability insurance policies from various providers. Its website combines digital comparison tools with support from licensed agents to help users evaluate, select and manage their insurance coverage.
Founded: 2017
Focus: Intelligent Business Solutions
What it does: Howso (formerly Diveplane) is an AI reasoning engine built on information and probability theory as an alternative to traditional neural networks. By operating directly on an enterprise’s source data, its software generates predictions, insights and synthetic data while providing clear data attribution and auditable explanations for its outputs.
Founded: 2017
Focus: Alumni Investing
What it does: Alumshares is an online investment platform that enables university alumni to discover and invest in university-affiliated startups and spinouts. The company creates legal investment vehicles around vetted opportunities, allowing university graduates to pool capital, leverage their alumni network and track private-market investments tied to their alma maters.
Founded: 2012
Focus: Healthtech
What it does: Flatiron Health develops technology to advance cancer research and care. Its clinical research offerings, for example, can help with screening trial participants, developing a trial diversity plan and streamlining data transfers to improve study efficiency. The company has a Life Sciences Hub in the Raleigh-Durham area.
Founded: 2012
Focus: Healthtech
What it does: Click Therapeutics develops, validates and commercializes software as prescription medical treatments and software-enhanced drug therapies. Its platform combines clinical science, cognitive and neurobehavioral interventions and AI-enabled data analytics to deliver regulated, prescription mobile applications independently or alongside traditional pharmacotherapy for neurological, psychiatric and other chronic conditions.
Founded: 2016
Focus: Performance Management
What it does: Liine is an AI-powered call tracking, marketing analytics and ad optimization platform designed for healthcare, dental and veterinary practices. It evaluates patient interactions across calls and online forms and matches attribution data with EHR/PMS revenue metrics, which is then used to optimize digital ad spend toward booked appointments rather than clicks.
Founded: 2015
Focus: Collectibles E-commerce
What it does: Hip eCommerce manages and develops online marketplaces built specifically for collectibles, including stamps, postcards and comic books. Its platforms provide custom search engine features, category-tailored tools and dedicated community spaces that allow collectors and sellers to buy, sell and engage around their hobbies.
Founded: 2017
Focus: Predictive Analytics
What it does: Allstacks is an agentic AI platform designed to plan, manage, measure and optimize software creation for product and development teams. Its AI agents integrate across software development lifecycle tools and analyze project data to identify delivery risks early, evaluate developer productivity and AI coding impact and automate audit-ready software cost capitalization without manual timesheets.
Founded: 2011
Focus: Process Intelligence
What it does: Celonis is a process intelligence platform that uses process mining and business context to analyze, visualize and optimize operational workflows. It extracts event data from underlying enterprise IT systems to identify inefficiencies and bottlenecks, enabling organizations to improve execution, enact targeted automation and ground AI applications in relevant operations.
Founded: 2017
Focus: Asthma Management
What it does: VitalFlo is a proactive digital respiratory care platform that monitors and tracks patient pulmonary health for healthcare providers, hospitals and clinical trial teams. Its software combines in-office spirometry, remote at-home patient monitoring and data-based clinical decision support to help clinicians detect patient condition changes early and improve respiratory outcomes.
Founded: 2016
Focus: Healthcare
What it does: GRAIL is a healthcare company focused on early cancer detection using sequencing, population-scale clinical studies and data science. Its Galleri multi-cancer early detection blood test screens for a shared cancer signal across more than 50 cancer types, which can help identify potential malignancies before symptoms appear and predict where they originate in the body.
Founded: 2018
Focus: Software
What it does: BuildOps is a commercial field service and project management platform built for specialty contractors in HVAC, electrical, plumbing and mechanical trades. It connects scheduling, dispatch, invoicing, asset tracking and project financial management into a single system to keep field updates and office workflows organized.
Founded: 2016
Focus: Coworking Software
What it does: Coworks is a space management software platform designed for coworking spaces, flex offices, makerspaces and university entrepreneurship centers. It offers mobile-first tools to automate day-to-day operations such as room bookings, member management, automated billing and event scheduling.
