VP Strategy & Operations - Pioneering Intelligence Initiative

ABOUT PIONEERING INTELLIGENCE

Pioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio of AI-first companies. As part of Flagship’s integrated model of science, entrepreneurship, and capital, it transforms breakthrough ideas into world-changing companies, elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond.

THE ROLE 

Pioneering Intelligence is seeking a Vice President – Strategy & Operations to serve as the senior strategic and operational partner to the Head of the Pioneering Intelligence Initiative. This highly visible role combines future-back strategic development, operational excellence, and cross-portfolio collaboration, offering the opportunity to shape the trajectory of innovation across Flagship’s ecosystem. As the VP – Strategy & Operations, you will collaborate directly with the Head of the Pioneering Intelligence Initiative, responsible for co-developing and communicating a bold, future-back AI strategy, driving operational excellence across our technical and research organization, and orchestrating strategic collaborations across Flagship, its portfolio companies, and external global partners. This role requires visionary strategy, operational discipline, and exceptional relationship-building skills. 

KEY RESPONSIBILITIES

• Strategic Development: Co-create and continuously refine a future-back AI strategy with the Head of the Initiative and senior leadership across Flagship Pioneering. Anticipate global AI trends, competitive dynamics, talent market dynamics, and emerging opportunities, translating vision into actionable roadmaps.
• Operational Leadership: Oversee and optimize operational models for the Initiative’s teams spanning digital technologies, data platform, agentic AI, and molecular modeling. Support our team in establishing planning, processes, budgeting, and metrics to drive accountability, speed, and quality in execution.
• Global Engagement: Build and manage relationships with global technology partners, leading research institutions, AI industry leaders, and industry influencers. Represent the Initiative in strategic engagements with portfolio company executives, venture team leadership, and external stakeholders.
• Cross-Portfolio Integration: Drive alignment across Flagship Pioneering and its portfolio, ensuring Pioneering Intelligence accelerates value creation for each entity. Translate cross-company needs into shared technology strategies and joint execution plans. 

PROFESSIONAL EXPERIENCE & QUALIFICATIONS 

• Extensive experience in senior strategic roles (e.g., management consulting, corporate strategy VP, innovation leader) with a proven record of shaping and executing transformative initiatives.
• Strong understanding of AI trends, implications, and applications; technical fluency required.
• Demonstrated success in leading multi-disciplinary technical teams and implementing operational systems in dynamic, high-growth environments.
• Proven ability to operate effectively across geographies, industries, and stakeholder groups.
• Exceptional communication and narrative skills, with the ability to align value across technical teams to C-suite executives.
• Strong track record of cultivating trust and partnerships across internal and external senior stakeholders.  

Preferred Qualifications 

• Experience working at the intersection of AI and technology-driven innovation domains such as the life sciences, physical sciences, or engineering.
• Success translating AI strategy into concrete value.
• Familiarity with operating models for multi-disciplinary R&D or technical organizations.  

WHY PIONEERING INTELLIGENCE

At Flagship, you will help define the strategic and operational blueprint for AI across a global portfolio of pioneering companies. This role offers a rare combination of influence, execution, and impact—shaping not just the future of a single organization, but the trajectory of entire industries in human health, sustainability, and beyond. 

• Shape a bold strategy at the intersection of intelligence, science, business, and technology.
• Collaborate with visionary leaders across Flagship’s ecosystem and beyond.
• Lead with impact in a mission-driven culture where innovation thrives.
• Competitive compensation and benefits, including equity, commensurate with experience. 

ABOUT FLAGSHIP PIONEERING

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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