Heartflow is a medical technology company advancing the diagnosis and management of coronary artery disease, the #1 cause of death worldwide, using cutting-edge technology. The flagship product—an AI-driven, non-invasive cardiac test supported by the ACC/AHA Chest Pain Guidelines called the Heartflow FFRCT Analysis—provides a color-coded, 3D model of a patient’s coronary arteries indicating the impact blockages have on blood flow to the heart. Heartflow is the first AI-driven non-invasive integrated heart care solution across the CCTA pathway that helps clinicians identify stenoses in the coronary arteries (RoadMap™Analysis), assess coronary blood flow (FFRCT Analysis), and characterize and quantify coronary atherosclerosis (Plaque Analysis). Our pipeline of products is growing and so is our team; join us in helping to revolutionize precision heartcare.
Heartflow is a publicly traded company (HTFL) that has received international recognition for exceptional strides in healthcare innovation, is supported by medical societies around the world, cleared for use in the US, UK, Europe, Japan and Canada, and has been used for more than 500,000 patients worldwide.
Role Overview
We are seeking a highly strategic, analytically rigorous, and execution-oriented leader to partner directly with the Chief Product Officer to drive critical, high-impact initiatives across the business.
This role is designed for a leader who thrives in ambiguity, can rapidly structure complex problems, and is equally comfortable shaping strategic direction and leading cross-functional execution. The VP, Portfolio Strategy will work on opportunities and challenges that sit outside the normal operating cadence and in-flight roadmap: emerging technologies, transformational capabilities, new business models, portfolio shifts, strategic pilots, and other initiatives that require deep thinking, organizational alignment, and hands-on leadership.
For targeted initiatives, this role will also be asked to lead small, cross-functional core teams assembled around strategic questions or exploratory initiatives – bringing structure, momentum, and clarity to areas that are often early-stage, ambiguous, and highly consequential.
Key Responsibilities
Strategic Problem Solving & Opportunity Assessment
- Lead analysis and framing of complex strategic questions affecting product direction, technology investment, portfolio evolution, and organizational capabilities.
- Evaluate emerging technologies, market shifts, competitive dynamics, and adjacent opportunities to identify implications and strategic options for the business.
- Develop actionable recommendations supported by rigorous analysis, clear narratives, and executive-level communication materials.
- Translate broad strategic concepts into practical decision frameworks and implementation pathways.
Cross-Functional Initiative Leadership
- Serve as the leader for select high-priority strategic initiatives that fall outside typical functional ownership.
- Build and lead small cross-functional working teams across Product, Market Access, Regulatory, Clinical, Engineering, Commercial, and other functions as needed.
- Establish initiative structure, milestones, governance, communication cadence, and decision-making frameworks.
- Drive alignment among senior stakeholders while maintaining momentum in uncertain or evolving environments.
Innovation & Transformation Enablement
- Help the organization assess and operationalize transformational opportunities, including new technologies, workflows, capabilities, and operating models.
- Lead exploratory pilots, proof-of-concept programs, and early-stage strategic experiments.
- Identify barriers to adoption and help shape scalable approaches for broader organizational implementation.
Executive Partnership
- Act as a trusted advisor and strategic partner to executive leadership.
- Provide leverage to Product leadership by independently advancing critical initiatives and surfacing insights, risks, and recommendations.
Qualifications & Experience
- 15+ years of experience in strategy, product leadership, consulting, business transformation, innovation, or related leadership roles. MBA strongly preferred.
- Demonstrated ability to lead ambiguous, cross-functional strategic initiatives from concept through execution.
- Exceptional structured thinking and problem-solving capabilities.
- Strong executive communication skills, including the ability to distill complex topics into clear recommendations and compelling narratives.
- Experience influencing senior stakeholders across multiple functions without direct authority.
- Strong business acumen paired with technical curiosity and comfort engaging with emerging technologies and evolving market dynamics.
- Proven ability to operate effectively in environments with incomplete information and evolving priorities.
- High degree of ownership, initiative, adaptability, and judgment.
Ideal Candidate Profile
The ideal candidate is:
- A systems thinker who can connect market trends, customer needs, technology evolution, and business strategy.
- Equally comfortable in strategic discussions and operational execution.
- Naturally curious and energized by unfamiliar or undefined problems.
- Able to bring order and clarity to situations that lack precedent or structure.
- Credible with both technical and commercial stakeholders.
- Calm, pragmatic, and highly effective in fast-moving environments.
- Motivated by impact, influence, and organizational transformation rather than narrow functional ownership.
A reasonable estimate of the yearly base compensation range is $325,000 to $375,000, bonus, and equity. #LI-Hybrid; #LI-IB1
Skills Required
- 15+ years of experience in strategy, product leadership, consulting, business transformation, or innovation
- MBA strongly preferred
- Demonstrated ability to lead ambiguous, cross-functional strategic initiatives from concept through execution
- Exceptional structured thinking and problem-solving capabilities
- Strong executive communication skills
- Experience influencing senior stakeholders across multiple functions without direct authority
- Strong business acumen with technical curiosity
- Proven ability to operate effectively in ambiguous environments
What We Do
Heartflow is the global leader in AI-driven coronary artery disease (CAD) management, transforming how CAD — the world’s leading cause of death — is diagnosed and treated. Our advanced technology generates personalized, precision 3D heart models from a single CT scan, providing clinicians with the clarity and confidence to deliver earlier, more effective treatments — transforming CAD into a disease that can be managed for life. Heartflow One is the only complete, non-invasive, precision coronary care platform providing patient insights throughout the guideline-directed CCTA pathway. The AI-driven platform — including Roadmap™ Analysis, FFRCT Analysis and Plaque Analysis — is supported by the ACC/AHA Chest Pain Guideline and backed by more than 600 peer-reviewed publications. With over 400,000 patients treated, more than 1,400 leading institutions adopting our solution, and 99.5% of U.S. lives covered — Heartflow is redefining the standard of coronary care. We're a global company, with employees across the United States, Europe and Japan. Our headquarters are in Mountain View, California, with additional offices in California, Texas, the UK, and Japan. We believe CAD shouldn’t be a silent threat. By making it screenable, diagnosable, and manageable, we’re changing the story of CAD, empowering clinicians to save lives and giving patients more time for what matters most.
Why Work With Us
Join Us to Rewrite the Story of CAD.
