Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company developing cell therapies for patients suffering from autoimmune diseases. Guided by our core values — Stay True to Why, Collaborate to Accelerate, Lead with Clarity, Boldly Innovative, and Own the Outcome — we are committed to transforming the future of treatment for autoimmune disease. Join us at the forefront of cell therapy innovation and help redefine what’s possible.
Title: Vice President, Commercial Operations
Reports to: Chief Commercial Officer
Location: Remote (West Coast preferred) or Emeryville, CA Hybrid
Position Summary
Kyverna is seeking a strategic and execution-oriented Vice President, Commercial Operations to build and lead a world-class commercial operations organization supporting the launch and commercialization of innovative cell therapies for autoimmune diseases.
As part of the Commercial Leadership Team, the VP will be responsible for developing scalable commercial infrastructure, analytics, forecasting, field operations, CRM, incentives, data strategy, market insights, and operational excellence across the commercial organization. The ideal candidate brings extensive experience leading commercial operations in biotechnology, including launch preparation, specialty therapeutics, cell therapy products, buy-and-bill reimbursement models, and complex patient journeys. Experience supporting autoimmune, neurology, CAR-T, rare disease, or specialty biologics launches is strongly preferred.
Responsibilities
- Build and scale the Commercial Operations function to support pre-commercial through commercial-stage growth.
- Partner with Commercial Leadership to develop launch strategies, go-to-market models, field deployment plans, and operational infrastructure.
- Lead launch readiness activities including territory alignment, targeting, incentive compensation, CRM implementation, analytics, and reporting.
- Develop operational frameworks to support specialty product commercialization, including infused and buy-and-bill reimbursement environments.
- Support long-range planning, annual operating planning, and commercial forecasting activities.
- Lead all field operations activities including sales force sizing, structure, alignment, targeting, call planning, and performance analytics.
- Oversee incentive compensation design, administration, and optimization aligned with business objectives.
- Establish KPIs, dashboards, and reporting frameworks to measure commercial effectiveness and drive data-informed decision-making.
- Partner with field leadership to optimize execution, productivity, and customer engagement strategies.
- Ensure operational excellence across CRM systems, field tools, data governance, and commercial technologies.
- Lead forecasting, market analytics, competitive intelligence, and business insights capabilities.
- Translate complex market, customer, and performance data into actionable commercial strategic recommendations.
- Partner with Market Access and Finance to support pricing, reimbursement, and access planning activities.
- Build scalable data infrastructure and reporting capabilities to support executive decision-making.
- Drive adoption and optimization of analytics platforms and commercial technologies.
- Collaborate closely with Marketing, Sales, Market Access, Medical Affairs, Patient Services, Regulatory, Compliance, and IT to ensure coordinated commercial execution.
- Serve as a key strategic advisor to executive leadership on commercialization strategy and operational planning.
- Partner with Compliance and Legal to develop Field Compliance SOPs and ensure all commercial activities adhere to regulatory and corporate standards.
- Support alliance management and cross-functional governance processes as needed.
- Team Leadership
- Recruit, develop, and lead a high-performing Commercial Operations organization.
- Foster a culture of accountability, collaboration, innovation, and continuous improvement.
- Mentor and develop team members while building scalable organizational capabilities aligned with company growth.
Commercial Strategy & Launch Readiness
Sales & Field Operations
Commercial Analytics & Insights
Cross-Functional Leadership
Qualifications
- Bachelor’s degree required; MBA or advanced degree preferred.
- 15+ years of biotechnology or pharmaceutical commercial experience with significant leadership experience in Commercial Operations.
- Demonstrated success supporting multiple product launches in specialty therapeutics, oncology, cell therapy, CAR-T, neurology, rare disease, or other complex treatment settings strongly preferred.
- Deep expertise in commercial operations including forecasting, analytics, field operations, CRM, incentive compensation, targeting, and reporting.
- Strong understanding of specialty pharmacy, infused products, buy-and-bill reimbursement, and complex patient access models preferred.
- Experience building commercial infrastructure in emerging or growth-stage biotechnology companies highly preferred.
- Proven leadership in cross-functional commercial launch planning and execution.
- Strong analytical and strategic thinking capabilities with ability to synthesize multiple data points, assess trends and translate into actionable business insights.
- Experience with commercial systems and platforms including CRM, data visualization, incentive compensation, and analytics tools.
- Excellent executive presence, communication, and stakeholder management skills.
- Demonstrated ability to operate effectively in highly matrixed, fast-paced environments.
- Strong people leadership, organizational development, and talent management capabilities.
- Ability to travel as needed for commercial meetings, field engagement, conferences, and company activities.
The national salary range for this position is $300K to $340K USD annually. This salary range is an estimate of what we reasonably expect to pay for this position, and the actual salary may vary based on factors including experience, education, geographic location, internal equity, and market data. This position is also eligible for annual bonus, equity, benefits, and participation in the Company’s stock plan.
Skills Required
- Bachelor's degree required; MBA or advanced degree preferred
- 15+ years of biotechnology or pharmaceutical commercial experience
- Significant leadership experience in Commercial Operations
- Demonstrated success supporting multiple product launches in specialty therapeutics
- Deep expertise in commercial operations including forecasting, analytics, field operations
What We Do
Kyverna is a cell therapy company engineering and developing a new class of curative living medicines for inflammatory and autoimmune diseases. Using its SmarTcell™ approach which includes synReg-T cell and synNotch CAR-T technology platforms, Kyverna reprograms T cells to target and selectively suppress or eliminate autoreactive immune cells. The company’s goal is to develop therapies that are selective, potent and durable to tame autoimmunity. We build interdisciplinary teams that bring a broad range of experiences and scientific expertise together to develop medicines that will free patients from the siege of autoimmune diseases and bring curiosity for exploring and creating the unknown. Our commitment to our employees is to foster an open, supportive, and inclusive environment where we create opportunities for individuals to learn and grow to their full potential at every level. synNotch is a trademark of Gilead/Kite.
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