Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company developing cell therapies for patients suffering from autoimmune diseases. Guided by our core values, Stay True to Why, Collaborate to Accelerate, Lead with Clarity, Boldly Innovative, and Own the Outcome, we are committed to transforming the future of treatment for autoimmune disease. Join us at the forefront of cell therapy innovation and help redefine what’s possible.
Position Overview
Kyverna is seeking Vice President, Sales to lead the development and execution of the U.S. commercial sales and go-to-market strategy for a pioneering portfolio of CAR-T therapies. This executive leader will be responsible for building and scaling a high-performing specialty sales organization focused on driving successful launches, maximizing market penetration, and delivering exceptional customer engagement across academic medical centers, integrated delivery networks, community neurology practices, and specialized treatment centers.
The ideal candidate brings a proven track record of commercial leadership in rare disease, neurology, cell and gene therapy, oncology, immunology, or other highly specialized therapeutic areas. This individual will possess deep expertise in launch excellence, account-based selling, treatment center engagement, and navigating complex reimbursement and site-of-care environments.
Department: Commercial
Location: Remote (United States)
Reports To: Chief Commercial Officer
Responsibilities
- Develop and execute the U.S. sales strategy supporting the commercialization of CAR-T for autoimmune diseases.
- Build and lead a best-in-class specialty sales organization capable of supporting current and future product launches.
- Establish commercial objectives, territory design, targeting strategies, and deployment models aligned with corporate goals.
- Drive revenue growth while ensuring compliance with all regulatory, legal, and company requirements.
- Partner with executive leadership to shape long-term commercial strategy and portfolio planning.
- Develop and execute the U.S. sales strategy supporting the commercialization of CAR-T for autoimmune diseases.
- Lead commercialization efforts across the CAR-T ecosystem, including treatment centers, referring physicians, infusion centers, and hospital systems.
- Develop strategies to optimize treatment center activation, patient identification, referral pathways, and patient access.
- Collaborate closely with Market Access, Cell Therapy Operations, Patient Services, and Medical Affairs to ensure seamless therapy adoption.
- Understand and address the complexities associated with cell collection, manufacturing, logistics, reimbursement, and site readiness.
- Monitor evolving CAR-T market dynamics, competitive intelligence, and emerging treatment paradigms.
- Establish and expand relationships with key neurology stakeholders, including academic centers, comprehensive neuroscience programs, and community neurologists.
- Drive customer engagement strategies supporting therapies for autoimmune neurological disorders, neurodegenerative diseases, and other complex neurological conditions.
- Develop disease-state education and value-based customer engagement approaches.
- Partner with Medical Affairs to ensure effective scientific exchange and customer education initiatives.
- Recruit, develop, and retain top-performing regional sales leaders and field sales professionals.
- Foster a high-performance culture focused on accountability, collaboration, innovation, and patient impact.
- Establish performance expectations, coaching programs, succession planning, and talent development initiatives.
- Lead ongoing training efforts focused on disease state expertise, clinical data, reimbursement, and customer engagement excellence.
- Partner closely with Market Access, Medical Affairs, Marketing, Commercial Operations, Patient Services, Legal, Compliance, and Finance.
- Ensure alignment between field execution and broader commercial strategies.
- Support forecasting, business planning, resource allocation, and launch readiness activities.
- Provide field insights to inform brand strategy, lifecycle planning, and evidence generation priorities.
- Establish and monitor KPIs related to sales performance, account engagement, treatment center activation, patient referrals, and market penetration.
- Utilize data analytics to optimize territory performance and resource deployment.
- Deliver regular business reviews and strategic recommendations to executive leadership.
- Identify opportunities to improve commercial effectiveness and customer experience.
Commercial Strategy & Leadership
CAR-T Commercial Excellence
Neurology Market Leadership
Sales Organization Development
Cross-Functional Collaboration
Business Analytics & Performance Management
Qualifications
- Bachelor's degree required; advanced degree (MBA, PharmD, PhD, or other relevant graduate degree) preferred.
- Minimum 15 years of biopharmaceutical commercial experience.
- Minimum 8 years of progressive sales leadership experience, including leading national specialty sales teams.
- Demonstrated success launching and commercializing specialty, rare disease, neurology, oncology, immunology, or cell and gene therapies.
- Deep understanding of specialty reimbursement, payer dynamics, treatment center engagement, and patient access.
- Experience managing field teams supporting highly complex therapies and specialized provider networks.
- Proven ability to build, lead, and scale high-performing commercial organizations.
- Direct CAR-T, cell therapy, gene therapy, or oncology commercialization experience.
- Neurology commercialization experience, particularly within autoimmune or rare neurological disorders.
- Experience launching products through limited distribution networks and specialized treatment centers.
- Strong understanding of buy-and-bill reimbursement models, specialty pharmacy, specialty distribution, and site-of-care considerations.
Preferred
The national salary range for this position is from $300,000 to $340,000 USD annually. This salary range is an estimate of what we reasonably expect to pay for this posted position, and the actual salary may vary based on various factors, including without limitation individual education, experience, tenure, skills and abilities, as well as internal equity and alignment with market data. This position is also eligible for bonus, benefits, and participation in Company’s stock plan.
Skills Required
- Bachelor's degree
- Advanced degree (MBA, PharmD, PhD, or other relevant graduate degree)
- Minimum 15 years of biopharmaceutical commercial experience
- Minimum 8 years of progressive sales leadership experience, including leading national specialty sales teams
- Demonstrated success launching and commercializing specialty, rare disease, neurology, oncology, immunology, or cell and gene therapies
- Deep understanding of specialty reimbursement, payer dynamics, treatment center engagement, and patient access
- Experience managing field teams supporting highly complex therapies and specialized provider networks
- Proven ability to build, lead, and scale high-performing commercial organizations
- Direct CAR-T, cell therapy, gene therapy, or oncology commercialization experience
- Neurology commercialization experience, particularly within autoimmune or rare neurological disorders
- Experience launching products through limited distribution networks and specialized treatment centers
- Strong understanding of buy-and-bill reimbursement models, specialty pharmacy, specialty distribution, and site-of-care considerations
What We Do
Kyverna is a cell therapy company engineering and developing a new class of curative living medicines for inflammatory and autoimmune diseases. Using its SmarTcell™ approach which includes synReg-T cell and synNotch CAR-T technology platforms, Kyverna reprograms T cells to target and selectively suppress or eliminate autoreactive immune cells. The company’s goal is to develop therapies that are selective, potent and durable to tame autoimmunity. We build interdisciplinary teams that bring a broad range of experiences and scientific expertise together to develop medicines that will free patients from the siege of autoimmune diseases and bring curiosity for exploring and creating the unknown. Our commitment to our employees is to foster an open, supportive, and inclusive environment where we create opportunities for individuals to learn and grow to their full potential at every level. synNotch is a trademark of Gilead/Kite.
