Vice President, Global Supply Chain

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As we scale toward global commercialization, we are seeking a strategic and execution-oriented leader, Vice President, Global Supply Chain reporting to SVP of PDM to lead our end-to-end supply chain operations across clinical and commercial programs.  Playing a senior leadership role within Pharmaceutical Development and Manufacturing (PDM) organization, this individual will be responsible for building and optimizing a global, compliant, and scalable supply chain function - encompassing clinical trial material supply, commercial product readiness, procurement, manufacturing operations, planning, logistics, and distribution. The role requires deep expertise in small molecule pharmaceutical operations, an understanding of the oncology development lifecycle, and the ability to thrive in a dynamic, fast-paced environment.

• Strategic Supply Chain Leadership

• Develop and execute the global supply chain strategy to support late-stage development and commercial readiness, with an emphasis on scalability, cost-efficiency, and regulatory compliance.

• Serve as a key operational leader contributing to corporate planning, global launch strategies, and commercial supply chain buildout.

• Partner with cross-functiona key stakeholders to effectively influence senior leadership’s decisions on global supply chain strategy.

• Clinical & Commercial Supply Management

  • Oversee supply of clinical trial materials across global studies in alignment with Clinical Operations, CMC, and Regulatory teams.

  • Lead commercialization planning and execution for late-stage assets, ensuring timely product availability and compliant distribution in the U.S. and ex-U.S. markets.

• Manufacturing & External Network Oversight

  • Manage relationships with external manufacturing partners (CDMOs) across drug substance and drug product for small molecule assets.

  • Ensure capacity planning, tech transfer, and commercial-scale readiness in coordination with Technical Operations and Quality.

• Global Planning, Logistics & Systems

  • Direct global demand forecasting, supply planning, and inventory strategies to support clinical and commercial needs.

  • Implement and enhance ERP and digital supply tools to improve visibility, analytics, and performance management.

  • Oversee global logistics, including cold chain handling if applicable.

• Quality, Compliance & Risk Mitigation

  • Ensure supply chain operations comply with GMP/GDP and global regulatory requirements (e.g., FDA, EMA, DSCSA, FMD).

  • Proactively identify and mitigate risks across the supply chain, including business continuity planning and scenario modeling.

• Team Leadership & Organizational Development

  • Build and lead a high-performing global supply chain organization, fostering a culture of collaboration, accountability, and operational excellence.

  • Define key performance metrics and drive continuous improvement across all supply chain functions.

Required Skills, Experience and Education:

• Minimum Bachelor’s degree in Supply Chain, Life Sciences, Engineering, or related field (MBA or advanced degree preferred).

• 18+ years of progressive supply chain leadership, with strong experience in small molecule pharmaceuticals, including clinical and commercial supply.

• Proven success building or scaling supply chain operations in a public, late-stage biotech or pharma company.

• Deep understanding of GMP, GDP, and international regulatory expectations, with launch readiness experience in the U.S. and ex-U.S. markets.

• Experience with outsourced manufacturing models and managing a global CDMO network.

• Strong systems knowledge (e.g., NetSuit, SAP, Oracle) and familiarity with serialization, DSCSA, and global trade compliance.

• Excellent leadership, communication, and cross-functional collaboration skills, particularly with Quality, Regulatory, CMC, Technical Operations, and Commercial functions.

Preferred Skills:

• Prior oncology supply chain experience, particularly with accelerated regulatory pathways.

• Experience launching commercial products globally, including establishing third-party logistics (3PL) and distribution partners.

• Knowledge of sustainability, ESG practices, and digital innovation in pharmaceutical supply chains. #LI-Hybrid  #LI-GL1