Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
The Discovery Pharmacology Intern will support research efforts at Arrowhead Pharmaceuticals by contributing to studies focused on early CNS programs. This internship offers hands-on laboratory experience characterizing protein expression in human cell lines and analyzing experimental data to better understand biological mechanisms relevant to therapeutic development. The intern will work closely with scientists to generate and interpret data and will summarize findings in a scientific poster presented at the end of the internship.
This is an 11-week Summer Internship Program paying $24.00 per hour and requires full-time, onsite work five days per week at the designated location.
Responsibilities
- Support experiments to characterize ATXN1 protein expression in human cell lines, including healthy and patient-derived models.
- Perform cell culture and aseptic techniques under supervision.
- Conduct immunoassays, including use of platforms such as JESS, as applicable
- Analyze experimental data and organize results using appropriate tools.
- Maintain detailed and accurate experimental records in accordance with laboratory standards.
- Summarize research findings and prepare a scientific poster and/or PowerPoint presentation.
- Present project results to the research team toward the end of the internship.
- Collaborate with team members and participate in group discussions and meetings.
Requirements
- Currently enrolled student at an accredited university or college, majoring in a biology-related field such as Cell Biology, Molecular Biology, Human Biology, Neuroscience, or a related discipline.
- Completion of relevant coursework in biology or life sciences.
- Completion of coursework in Molecular Biology, Cell Biology, Neurobiology, and/or Biotechnology
- Familiarity with protein expression analysis, immunoassays, or cell-based assays.
- Interest in translational research or neuroscience-related drug discovery.
- Proficiency in Microsoft Office applications.
- Strong curiosity and motivation to learn new laboratory techniques.
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
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What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients. Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety. Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline. Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations. Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
