Compensation:
$120,000 - $170,000
Role Overview
The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.
Key Responsibilities
Provide structural biology support for variant analyses through structure-function relationship interpretation.
Develop novel methods, protocols, and tools for structural modeling, molecular dynamics, and clinical variant assessment on internal platforms.
Partner with statisticians and data scientists to validate algorithms and data collection workflows.
Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects.
Write testable, production-grade code adhering to SDLC standards and code review best practices.
Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff.
Direct and lead the structural team through both soft and explicit leadership ensuring timely project completion
Support, inform, and educate leadership and stakeholders about project progress and blockers.
Qualifications & Competencies
Education: PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.
Experience: Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years of post-doctoral or industrial experience and 2 years management experience.
Technical Skills: Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software. Strong background in systems biology, molecular dynamics, and experimental techniques (X-ray, Cryo-EM).
PRIVACY NOTICES
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Equal Opportunity Employer
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Skills Required
- PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent
- At least 5 years of R&D experience in computational structural biology or related fields
- At least 2 years of post-doctoral or industrial experience
- At least 2 years of management experience
- Fluency or proficiency in Python, R, Perl, C, C++, Java, and SQL
- Experience with bioinformatics and structural modeling software
- Strong background in systems biology and molecular dynamics
- Experience with experimental techniques including X-ray and cryo-electron microscopy
What the Team is Saying
Tempus AI Compensation & Benefits Highlights
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Healthcare Strength — Health coverage is described as comprehensive, including medical, dental, vision, life and disability insurance, plus mental‑health resources and HSA/FSA options, with core items employer‑verified in mid‑2026.
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Leave & Time Off Breadth — Paid time off and parental leave are consistently part of the package, with parental leave commonly cited around three months and related pages noted as recently employer‑verified.
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Wellbeing & Lifestyle Benefits — Everyday perks such as commuter benefits, on‑site meals and coffee programs, gym discounts, charitable matching, ERGs, pet insurance, and team events are widely highlighted, with some amenities available in select offices.
Tempus AI Insights
What We Do
We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed. At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information, visit tempus.com.
Why Work With Us
We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.
Gallery
Tempus AI Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
Most of the team follows a hybrid policy, with some roles allowing for a fully remote arrangement and some roles being onsite only.
