Natera is seeking a Staff Software Engineer to join a small, high-leverage team inside the Case Management Platform (CMP) organization. This is a new and intentionally unique role: you will sit organizationally within CMP — the engine that drives Natera's cases from order through result — and work shoulder-to-shoulder on priorities set by the commerce side of the business. Your job is to bridge the gap between how Natera sells, orders, and interacts with customers and how Natera fulfills every one of those commitments in the lab.
You will be a force multiplier — fluent in modern AI tools, an orchestrator of agents, and comfortable owning problems end-to-end from a napkin sketch through production.
If you light up at the intersection of commerce workflows and operational systems, build with AI as a native part of your toolkit, and want to work on software whose outcomes are measured in patient impact — this is a role worth your attention.
PRIMARY RESPONSIBILITIES- Own high-impact initiatives end-to-end — from problem framing through design, implementation, release, and operation — in service of commerce-driven priorities that land in CMP
- Design and build cloud-native services on AWS, with a strong bias toward stateless, event-driven architectures (AWS Lambda and similar serverless patterns, SQS/SNS/EventBridge, API Gateway, DynamoDB/RDS)
- Act as an orchestrator of AI agents and AI-assisted workflows: compose, direct, and evaluate agent systems to accelerate development, reduce manual toil, and solve problems that would otherwise require a much larger team
- Translate ambiguous business needs — spanning commerce systems and fulfillment operations — into clear technical specifications, APIs, and operations-friendly services
- Write your own stories; break down epics, identify dependencies, estimate complexity, and drive delivery without needing tickets handed to you
- Set the technical bar through strong code, thoughtful design reviews, and mentorship of other engineers across CMP
- Partner directly with commerce product managers, business stakeholders, and CMP peers; translate between those worlds and shield each from the other's complexity
- Participate in on-call rotations and production support; own the fix when something you built breaks, regardless of who wrote the original code
- Challenge the status quo; propose better patterns, tools, and ways of working — and bring teammates along
- Deliver quality software in a regulated environment: automation-first testing, shift-left mindset, "works on my machine" is never the answer
Compliance and training
- This role works with Protected Health Information (PHI) on a regular basis in both paper and electronic form
- Employee must complete HIPAA/PHI privacy, General Policies and Procedure Compliance, and security training within the first 30 days of hire, and maintain current status on all Natera training requirements
- Employee must pass a post-offer criminal background check
- BS in Computer Science, a comparable program, or equivalent experience; MS preferred
- 10+ years of professional software engineering experience, including meaningful time building complex data or process-management applications
- Strong fluency in Java or another modern object-oriented language (Kotlin, C#, Python with OO design, etc.); comfortable moving between languages when the job calls for it
- Deep hands-on experience with AWS, including serverless and stateless patterns (Lambda, Step Functions, API Gateway, event-driven messaging) and relational and non-relational data stores
- Demonstrated adoption of AI-assisted development — not just "I've used Copilot," but a genuine, current practice of composing and orchestrating AI tools and agents to deliver real work
- Experience designing and operating distributed systems, including observability, resilience, security, and performance in production
- Strong SQL and data modeling skills
- Experience partnering directly with product managers and non-engineering stakeholders to shape requirements and trade-offs
- Experience in biotech, healthcare, commerce, order management, or another regulated or operations-critical domain is a strong plus
- Deep understanding of software engineering fundamentals: OO, SOLID, design patterns, API design, and clean architecture
- AI-native engineer — treats AI tools and agents as standard parts of the workflow and continually raises the ceiling on what they can do
- Fluent in cloud infrastructure and in building the right thing for the shape of the problem — not everything is a Lambda, and not everything is a container
- Full-stack comfort when needed, with a backend/platform center of gravity
- Excellent written and verbal communication; able to make the complex understandable to commerce stakeholders and the ambiguous actionable for engineers
- Extreme ownership — keeps promises, surfaces blockers early, closes loops without being asked
- "Yes if" attitude; focused on paths forward, explicit about trade-offs
- Humility and curiosity; reads code written by others, asks "why" until it reaches the real constraint, and welcomes being wrong when it leads to a better answer
- Commitment to diversity in engineering and to building a team where the best idea wins
OUR OPPORTUNITY
Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
WHAT WE OFFER
Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!
For more information, visit www.natera.com.
Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.
If you are based in California, we encourage you to read this important information for California residents.
Link: https://www.natera.com/notice-of-data-collection-california-residents/
Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
For more information:
- BBB announcement on job scams
- FBI Cyber Crime resource page
Skills Required
- Bachelor’s degree in Computer Science, a comparable program, or equivalent experience
- 10+ years of professional software engineering experience
- Experience building complex data or process-management applications
- Strong fluency in Java or another modern object-oriented language, such as Kotlin, C#, or Python with object-oriented design
- Deep hands-on AWS experience, including serverless, stateless, and event-driven patterns
- Experience with Lambda, Step Functions, API Gateway, event-driven messaging, and relational and non-relational data stores
- Demonstrated adoption and orchestration of AI-assisted development tools and agents
- Experience designing and operating distributed systems in production
- Strong SQL and data modeling skills
- Experience with observability, resilience, security, and performance for production systems
- Experience partnering with product managers and non-engineering stakeholders to shape requirements and trade-offs
- Master’s degree
- Experience in biotech, healthcare, commerce, order management, or another regulated or operations-critical domain
Natera Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Natera and has not been reviewed or approved by Natera.
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Healthcare Strength — Medical plan choice, fertility support, and free Natera tests for employees and families are emphasized alongside dental, vision, and life/disability coverage. These elements indicate robust core health coverage.
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Equity Value & Accessibility — An Employee Stock Purchase Plan is available, and equity is described as a significant part of compensation in some roles. This accessibility to ownership can meaningfully augment overall pay.
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Leave & Time Off Breadth — A flexible, no‑accrual PTO policy and parental leave are positioned as part of the package. This breadth suggests meaningful time‑off provisions are included.
Natera Insights
What We Do
Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. Where some set out to build a test, we set out to achieve a mission: change the management of disease worldwide by using DNA testing to proactively inform treatment. Through a cfDNA technology platform approach, we've pioneered noninvasive testing in unlimited applications—each with their own potential to revolutionize care for patients. #TeamNatera includes clinicians, scientists, biostatisticians, researchers, and laboratory professionals from around the world. Our diverse teams blend a passion for patients with deep clinical, scientific, and technological roots. Natera’s tests are validated by more than 100 peer-reviewed publications that demonstrate high accuracy.
