Staff Bioinformatics Scientist

What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Position Summary:

Our team specializes in developing a fast and accurate FPGA-accelerated platform called DRAGEN, for the secondary analysis of NGS genomic data, together with integration in the ICA Cloud platform for scalability and data interpretation. The platform covers a wide range of pipelines including WGS and targeted (enriched/amplicon) germline, WGS and targeted somatic (T/N and tumor-only), DNA/RNA, small variants, CNV, and structural variants.

The Staff Bioinformatics Scientist will be responsible for developing novel methods to extract biological meaning from genomic samples. They will be responsible for designing and implementing solutions in the form of model design and software as well as collaborating with others to do so in a team-focused workflow. They will be responsible for helping to define and drive the success of the complete product, including defining requirements, assessing accuracy, streamlining customer experience, and enabling end-user applications. They will have a strong background in computer science, algorithms, statistics, and/or digital signal processing in addition to expertise in genomics, next generation sequencing, and a broad ecosystem of related assays and biotechnologies. The ideal candidate will have a track record of both innovative and pragmatic bioinformatics methods development and delivery. They will be a proven team player with leadership skills and experience.

Responsibilities:

• Design, prototype and implement innovative computational and/or statistical algorithms to extract meaningful biological signal from sequencing assays.

• These algorithms may be applied to various aspects of genomics, such as DNA genomics (germline or somatic), RNA genomics, epigenomics, metagenomics or immunogenomics.

• Implement algorithms in production-grade C/C++ software. Collaborate deeply with inter-disciplinary teams (QC/QA test teams, FPGA teams, SW teams, clinical genomics teams) as the platform has many different end-users with different requirements and applications to ensure a smooth, end-to-end workflow with external organizations.

• Analyze, integrate, model and interpret experimental data.

• Engage with external customers’ scientific teams to build product credibility and define emerging requirements.

• Clearly communicate technical methods and findings across internal teams with diverse expertise. Prepare internal and external facing technical documentation and marketing assets related to project research.

Listed responsibilities are an essential, but not exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs.

Requirements:

• Expertise in genomics and experience with analyzing error modes and actionable signal in genomic data sets

• Expertise in algorithms for NGS secondary analysis: Mapping-Alignment and Variant Calling

• Strong background in computer science, algorithms, statistics, and/or digital signal processing

• Expertise in high-performance software development using C++/C or similar languages

• Expertise in next generation sequencing assays and related biotechnology ecosystems.

• Expertise in common sequencing applications such as research in rare disease, cancer and population genetics.

Experience/Education:

• PhD in Bioinformatics, Biology, Computational Biology, Biostatistics, Computer Science with 3+ years of relevant experience.

• Ability to contribute independently and collaboratively, and to excel in a fast-paced environment

• Proven team player with leadership skills and experience

• Demonstrated technical and people leaderships skills and a history of success working in cross functional teams

• Strong communicator with ability to maintain open communication with internal employees, managers and customers as needed, ability to communicate effectively with technical and non-technical end-users

• Experience with using version control systems such as git

The estimated base salary range for the Staff Bioinformatics Scientist role based in the United States of America is: $152,600 - $228,800. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

At Illumina, we strive to foster a diverse and inclusive workplace by cultivating an environment in which everyone contributes to our mission. Built on a strong foundation, Illumina has always been rooted in openness, collaboration, and seeking alternative views and perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and demonstrate our collective commitment to diversity and inclusion in the communities we live and work. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. If you require accommodation to complete the application or interview process, please contact [email protected]. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants.