The Role
Leads development, validation, maintenance, and documentation of clinical bioinformatics pipelines for high-volume patient sequencing data. Evaluates and triages data supporting clinical variant calls, oversees bioinformatics operations and metrics, and collaborates with engineering, laboratory, quality, and clinical teams to launch genomic products. Requires hands-on DNA sequencing analysis, Python coding or data analysis, and experience in clinical genomics or regulated environments is advantageous.
Summary Generated by Built In
Who We Are & What We Do
At Helix, our mission is simple: to help everyone improve their lives through their DNA.
Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics.
What is special about this role?
At Helix, our bioinformatics team creates cutting-edge NGS pipelines, handling high volumes of patient samples in a tightly regulated space. As a Staff Bioinformatics Scientist, you will lead efforts to ensure pipeline accuracy and reliability, guaranteeing high-quality and consistent results for our patients.
As a Staff Bioinformatics Scientist, you will:
- Develop new bioinformatics capabilities to expand use cases and drive volume
- Work cross-functionally with engineering, lab, quality, and clinical teams to launch new science products
- Support operations by evaluating and triaging bioinformatics data underlying clinical variant calls
- Oversee bioinformatics operations, including developing tools and methods to identify and track key metrics
- Develop, maintain, and document clinical analytical validations
About you:
- Masters with 5+ years of relevant experience or PhD with 3+ years of relevant experience
- Hands-on experience with analyzing DNA sequencing data
- Coding and/or data analysis experience in Python
- Strong cross-functional collaboration and communication skills
- A willingness to learn and adapt to new challenges to drive tasks to completion
Pluses:
- Subject matter knowledge in clinical genomics
- Experience across multiple -omics technologies (e.g. WES, WGS, RNA-seq, proteomics)
- Experience in a regulated environment (e.g. CLIA/CAP, FDA)
Expected Interview Process:
1) Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite 4) Offer
Expected Pay For This Role:
There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity
- Expected Helix Base: $146,000 - $196,000 per annum
- Expected Helix Discretionary Annual Bonus: 15% of your annual salary
- Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model.
Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:
- Comprehensive Health Insurance with Date of Hire eligibility
- Above average employer paid premium coverage
- 12 weeks Helix Paid Parental Leave option
- 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire
- Comprehensive Well-Being Benefits
- Flexible PTO
- Remote options for many roles and a home office stipend
What To Expect During Your First 90 days:
- First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U.
- Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities.
- Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission.
Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.
#LI-Remote
CompensationThe base pay range for this role is $146,000 – $196,000 per year.
Skills Required
- Master’s degree with at least 5 years of relevant experience
- PhD with at least 3 years of relevant experience
- Hands-on experience analyzing DNA sequencing data
- Coding and/or data analysis experience in Python
- Strong cross-functional collaboration skills
- Strong communication skills
- Willingness to learn and adapt to new challenges
- Subject matter knowledge in clinical genomics
- Experience with multiple omics technologies, such as WES, WGS, RNA-seq, or proteomics
- Experience in a regulated environment, such as CLIA/CAP or FDA
Helix Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Helix and has not been reviewed or approved by Helix.
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Leave & Time Off Breadth — Feedback suggests generous PTO, flexible time away, unlimited vacation, paid sick days, and paid parental leave support work–life balance. These policies are frequently highlighted alongside flexible scheduling.
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Healthcare Strength — Feedback suggests medical, dental, and vision coverage are complemented by a wellness program. Access to health-focused initiatives contributes to a comprehensive core benefits package.
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Wellbeing & Lifestyle Benefits — Feedback suggests commuter benefits, free daily meals, and onsite parking enhance day‑to‑day experience. Such perks, combined with flexible work arrangements, add lifestyle value beyond base pay.
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The Company
What We Do
Helix is a rapidly growing startup focused on personal genomics. Helix has a simple but powerful mission: to empower every person to improve their life through DNA. We’re creating an ecosystem where people can explore diverse and uniquely personalized applications provided by high-quality partners.
Why Work With Us
We are collaborators—scientists, engineers, designers, marketers, and more—working across four offices to solve complex challenges locked within the human genome. We are biased toward action as we strive to uphold integrity in sequencing, science, and communication. At Helix, transparency, collaboration, and empowerment drive us in all that we do.
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