The Role
Build and scale production bioinformatics systems that automate genomic variant curation and classification. Integrate evidence from ClinVar, gnomAD, PubMed, and other sources while applying classical and AI/ML approaches. Collaborate with scientists, product leaders, and clinical stakeholders to develop reliable, secure, maintainable pipelines. Staff-level responsibilities include framing ambiguous problems, setting technical direction, and making architecture and prioritization decisions across the product area.
Summary Generated by Built In
Who We Are & What We Do
At Helix, our mission is simple: to help everyone improve their lives through their DNA.
Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics.
What is special about this role?
You'll bridge the gap between genomic variants and the clinical answers that help patients act on their DNA. You'll partner with scientists and product leaders to turn promising prototypes into production systems that scale. Your code will power how Helix automates gene and variant curation for real patients.
We have openings for both Senior and Staff level Engineers. You may apply at either level, and we’ll consider your experience, qualifications and demonstrated scope when determining the right level.
As a Senior/Staff Bioinformatics Engineer, Clinical Applications, you will:
- Productionize curation workflows that support both classical and modern AI/ML approaches to variant classification.
- Automate evidence integration from sources such as ClinVar, gnomAD, and PubMed.
- Collaborate closely with scientists, product, and clinical stakeholders to ensure software solutions meet scientific and product requirements.
- Direct AI coding agents to accelerate development of curation pipelines, applying engineering judgment to validate correctness, security, and architectural fit before deployment.
- At Senior level, own defined projects end to end, make technical decisions within agreed priorities and architecture, and raise trade-offs that affect broader systems.
- At Staff level, independently frame ambiguous problems, set technical direction, and make consequential architecture and prioritisation decisions across the product area.
About you:
- Bachelor's degree in Science or related field with 7+ years (Senior) or 9+ years (Staff) of professional software development experience. Or, a Master's or Ph.D. with 3+ years (Senior) or 5+ years (Staff) of professional software development experience.
- Advanced proficiency in production-quality Python, relational databases, and cloud platforms such as AWS.
- Experience productionizing and scaling AI/ML software, especially agentic systems built with frameworks such as LangChain or LangGraph.
- Experience collaborating with scientists to integrate bioinformatics/NGS tools and databases into production workflows.
- Strong judgment evaluating AI-generated code and pipeline logic for correctness, security, and maintainability before it reaches production.
Pluses:
- Experience in clinical genomics, such as ACMG guidelines, clinical diagnostics, or Human Phenotype Ontology (HPO) terms.
- Experience developing regulated software, such as software as a medical device.
- At Staff level, the role may have the opportunity to take on people leadership responsibilities. Experience mentoring or managing others, or an interest in developing as a people leader, is a plus.
Expected Interview Process:
1) Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite 4) Offer
Expected Pay For This Role:
There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity
- Expected Helix Base: $161,500 - $219,625
- Expected Helix Discretionary Annual Bonus: 15% of your annual salary
- Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model.
Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:
- Comprehensive Health Insurance with Date of Hire eligibility
- Above average employer paid premium coverage
- 12 weeks Helix Paid Parental Leave option
- 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire
- Comprehensive Well-Being Benefits
- Flexible PTO
- Remote options for many roles and a home office stipend
What To Expect During Your First 90 days:
- First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U.
- Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities.
- Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission.
To learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice.
Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.
#LI-Remote
CompensationThe base pay range for this role is $134,000 – $179,000 per year.
Skills Required
- Bachelor’s degree in Science or a related field plus 7+ years of professional software development experience for Senior level or 9+ years for Staff level
- Master’s or Ph.D. plus 3+ years of professional software development experience for Senior level or 5+ years for Staff level
- Advanced proficiency in production-quality Python
- Experience with relational databases
- Experience with cloud platforms such as AWS
- Experience productionizing and scaling AI/ML software
- Experience with agentic systems and frameworks such as LangChain or LangGraph
- Experience collaborating with scientists to integrate bioinformatics or NGS tools and databases into production workflows
- Strong judgment evaluating AI-generated code and pipeline logic for correctness, security, and maintainability
- Experience in clinical genomics, including ACMG guidelines, clinical diagnostics, or HPO terms
- Experience developing regulated software, such as software as a medical device
- Experience mentoring or managing others, or interest in developing as a people leader
Helix Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Helix and has not been reviewed or approved by Helix.
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Leave & Time Off Breadth — Feedback suggests generous PTO, flexible time away, unlimited vacation, paid sick days, and paid parental leave support work–life balance. These policies are frequently highlighted alongside flexible scheduling.
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Healthcare Strength — Feedback suggests medical, dental, and vision coverage are complemented by a wellness program. Access to health-focused initiatives contributes to a comprehensive core benefits package.
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Wellbeing & Lifestyle Benefits — Feedback suggests commuter benefits, free daily meals, and onsite parking enhance day‑to‑day experience. Such perks, combined with flexible work arrangements, add lifestyle value beyond base pay.
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The Company
What We Do
Helix is a rapidly growing startup focused on personal genomics. Helix has a simple but powerful mission: to empower every person to improve their life through DNA. We’re creating an ecosystem where people can explore diverse and uniquely personalized applications provided by high-quality partners.
Why Work With Us
We are collaborators—scientists, engineers, designers, marketers, and more—working across four offices to solve complex challenges locked within the human genome. We are biased toward action as we strive to uphold integrity in sequencing, science, and communication. At Helix, transparency, collaboration, and empowerment drive us in all that we do.
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