At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.
Job Summary
The Sr. IT Infrastructure & Operations Engineer will play a critical role in supporting and advancing the IT infrastructure of a rapidly growing clinical-stage biotechnology company. This role requires a seasoned engineer who can design, implement, and maintain secure, scalable, and compliant infrastructure services while supporting a highly collaborative scientific, clinical, and business environment.
The ideal candidate will have hands-on expertise across cloud platforms, endpoint security, enterprise networking, and compliance frameworks. They will be a senior-level escalation point, driving operational excellence while ensuring IT systems meet regulatory requirements such as GxP for scientific systems and SOX (Sarbanes-Oxley) for financial and IT general controls. This individual will also serve as a trusted partner to Research, CMC, Clinical, Finance, and Corporate functions to deliver resilient, secure, and compliant IT services.
Primary Responsibilities
- Cloud & Infrastructure Operations
- Architect, manage, and optimize Microsoft Azure cloud services to support enterprise scalability, security, and high availability
- Maintain and administer the M365 platform (Exchange Online, SharePoint Online, Teams, OneDrive) with a focus on security, governance, and collaboration
- Support and enhance Cisco Meraki wireless infrastructure for secure, reliable connectivity across office, lab, and conference spaces
- Manage enterprise backup and disaster recovery solutions to ensure business continuity
- Oversee Zoom conference room technology for seamless hybrid collaboration and executive meetings
- Identity, Security & Compliance
- Administer and optimize Microsoft Entra ID for authentication, access management, and SSO integrations
- Manage Zscaler (ZIA/ZPA) for secure connectivity and zero-trust access to resources
- Deploy, configure, and support Microsoft Intune for device lifecycle management, policy enforcement, and compliance
- Oversee Microsoft Defender for Endpoint and related Microsoft security stack tools
- Administer Rapid7 for vulnerability detection, remediation, and reporting
- Partner with IT Security and Finance to support SOX IT General Controls (ITGCs), including access reviews, segregation of duties, change management, and IT audit evidence collection
- Support GxP compliance for regulated scientific systems, ensuring adherence to industry standards (21 CFR Part 11, NIST CSF, ISO, SOC2)
- Operational Support & Escalations
- Serve as Level 3 escalation point for complex endpoint, infrastructure, and application incidents
- Troubleshoot endpoint, scientific application, and collaboration platform issues
- Ensure patching, software deployment, and endpoint configuration meet compliance requirements
- Create and maintain IT operational documentation, SOPs, and knowledge base articles
- Projects & Innovation
- Lead infrastructure projects, upgrades, and system migrations to improve resilience and security posture
- Evaluate emerging technologies for alignment with company goals and compliance standards
- Mentor and coach junior IT team members to strengthen operational depth and expertise
- Deploy, maintain and support research applications (Graphpad, ELN, Smartsheet, Thinkcell, etc...)
Core Competencies (Required Skills)
- Technical Expertise: Proven ability to manage enterprise IT infrastructure with deep knowledge of Microsoft Azure, M365, Microsoft Entra ID, Intune, Cisco Meraki, Zscaler, Microsoft Defender, and Rapid7
- Regulatory Awareness: Strong understanding of compliance in a biotech environment, including GxP and SOX ITGCs, with hands-on audit support experience
- Problem Solving: Exceptional troubleshooting skills, able to handle Level 3 escalations across infrastructure, endpoints, and scientific systems
- Customer Focus: Ability to engage with scientists, clinicians, finance, and corporate staff with empathy, urgency, and professionalism
- Collaboration & Leadership: Comfortable working cross-functionally, mentoring junior staff, and communicating effectively with technical and non-technical stakeholders
- Documentation & Process: Skilled in producing clear, detailed SOPs, technical documentation, and audit-ready evidence.
Preferred Skills
- Experience supporting scientific IT systems (ELNs, LIMS, CMC systems, Clinical systems)
- Prior work in clinical-stage biotech or pharmaceutical companies
- Knowledge of vendor risk management, SaaS governance, and IT policies supporting regulated data
- Audit preparation and response for SOX financial audits and GxP vendor assessments
- Certifications such as:
- Microsoft Certified (Azure Administrator, Security Engineer, Entra ID)
- Cisco Meraki Specialist
- Security/Compliance Certifications (CISSP, CISM, CISA)
Education Requirements
- Bachelor’s degree in Information Technology, Computer Science, Engineering, or a related field; equivalent experience may be considered
- Minimum of 7 years of progressive IT infrastructure and operations experience, ideally in a regulated life sciences, biotech, or pharmaceutical environment
- Demonstrated track record of supporting both GxP and SOX compliance requirements
- Ongoing commitment to continuing education and certifications in cloud, security, and compliance technologies
Our Diversity, Equity & Inclusion Mission Statement: Keros is an inclusive company. We believe that diversity drives innovation. We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees. As such, Keros takes a holistic approach in mentoring, coaching, and developing all of our Keros team members.
Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.
Recruitment & Staffing Agencies:
Keros Therapeutics does not accept unsolicited resumes from any source other than the candidate directly. Any unsolicited submission by an agency to Keros is prohibited. Any resume submitted by an agency without a signed contract or expressed consent by a member of the Keros Therapeutics Human Resources Department, will be considered property of Keros Therapeutics, and no fee shall be owed with respect thereto.
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What We Do
Keros is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel treatments for patients suffering from rare hematologic and musculoskeletal disorders with high unmet medical need
