Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).
Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.
The Position
Reporting to our Co-CEO’s, the SVP of Program Leadership & Development will drive the advancement of our clinical-stage pipeline. This individual will be responsible for end-to-end leadership of one or more key development programs translating scientific innovation into clinical, regulatory, and commercial success.
The SVP of Program Leadership & Development will play a critical role in shaping program strategy, guiding cross-functional execution, and maximizing asset value from early development through late-stage trials and potential regulatory approval.
This role will serve as a core member of the Senior Leadership Team, partnering closely with Clinical Operations, Medical, Regulatory, Biometrics, CMC, Commercial and other functional leaders to drive the successful execution of Amylyx’s development portfolio.
In a lean and evolving biotech environment, this individual will operate both as an enterprise leader and a hands-on program leader, directly supporting key assets while building a scalable program leadership organization over time.
The Opportunity
This is a unique opportunity to shape and define how program leadership is executed within a growing biotech organization at a critical inflection point.
Build a New Function from the Ground Up - design and implement a modern program leadership model, including the evolution from traditional program management to a strategic Program Lead and Program Manager structure.
Operate as a True Peer to Clinical and Medical Leadership - serve as an equal partner to senior leaders across Clinical Operations, Medical, and Regulatory, helping shape asset strategy and execution.
Drive Impact Across the Full Development Lifecycle - lead programs spanning early-phase IND-enabling work through Phase 3 and potential NDA submission, with direct impact on key value-driving milestones.
Balance Strategy and Execution in a Lean Environment - play a dual role as both a strategic leader and hands-on program leader, directly influencing outcomes while building for future scale.
Shape Organizational Culture and Ways of Working - establish a highly collaborative, accountable, and transparent operating model that strengthens alignment across functions and reduces organizational friction.
Scale with the Portfolio - build and develop a high-performing team over time, aligned to the growth of the pipeline and key clinical milestones.
Responsibilities
Strategic Program Leadership
- Partner with Clinical Operations and Medical leadership to define and execute development strategies and plans across programs
- Drive program-level decision-making, including risk assessment, trade-offs, and prioritization
- Ensure alignment between asset strategy, clinical execution, and regulatory pathways
- Present program updates, risks, and opportunities to Executive Leadership and Board of Directors
Cross-Functional Integration & Alignment
- Serve as the central integrator across Medical, Clinical Operations, Regulatory, Biometrics, CMC, Commercial and other key functions
- Drive clarity of roles, decision-making, and accountability across program teams
- Proactively identify and resolve cross-functional misalignment, gaps, and competing priorities
Hands-On Program Execution
- Directly serve as Program Lead for one or more key assets, particularly in the early phase of the role
- Lead cross-functional team meetings, execution planning, and milestone delivery
- Translate strategic objectives into clear, aligned execution plans
Build & Scale Program Leadership
- Design and implement a program leadership model, including Program Leads and Program Managers
- Hire, develop, and lead program leadership talent over time as the organization grows
- Establish best practices, governance frameworks, and ways of working that enable scalability
Portfolio & Executive Contribution
- Contribute to portfolio prioritization, resource allocation, and strategic planning discussions at the leadership level
- Provide clear, actionable insights and recommendations to executive leadership
- Support the evolution of Amylyx’s development organization as it scales toward key clinical and regulatory milestones
Required Qualifications
- Advanced degree (PhD, MD, PharmD, or MD) in a relevant scientific discipline preferred; equivalent experience in drug development and program leadership will also be considered
- 20+ years of experience in the pharmaceutical or biotechnology industry, including significant experience leading cross-functional drug development programs
- Lead integrated clinical development plans (CDPs)
- Overseen protocol design, endpoints, and trial execution
- Demonstrated success in regulatory interactions (FDA, EMA)
- Significant experience leading cross-functional drug development programs, ideally spanning early development through late-stage clinical and/or regulatory milestones
- Demonstrated success in regulatory interactions (FDA, EMA)
- Prior experience serving as a Program Lead, Development Team Leader (DTL), Asset Team Lead or equivalent role, with accountability for cross-functional program execution
- Demonstrated ability to partner with Clinical Operations, Medical, and Regulatory leaders as a peer, influencing strategy and execution
- Experience operating in a biotech or similarly lean, fast-paced environment, with comfort navigating ambiguity and evolving priorities
- Proven track record of building or scaling teams and/or functions within a matrixed organization
- Strong leadership and collaboration skills, with the ability to align diverse stakeholders and drive decision-making in complex environments
- Hands-on, execution-oriented leadership style, with willingness to engage directly in program delivery when needed
- Excellent communication and interpersonal skills, with the ability to bridge scientific, clinical, and business perspectives
Work Location and Conditions
- At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis. Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
- When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.
Compensation
The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.
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Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
Skills Required
- Advanced degree (PhD, MD, PharmD) in a relevant scientific discipline
- 20+ years of experience in pharmaceutical or biotechnology industry
- Lead integrated clinical development plans
- Overseen protocol design, endpoints, and trial execution
- Demonstrated success in regulatory interactions (FDA, EMA)
- Experience operating in a biotech or fast-paced environment
- Strong leadership and collaboration skills
What We Do
Amylyx Pharmaceuticals, Inc. is a global company committed to the mission of discovery and development of treatments for relentless and progressing neurodegenerative diseases. We work collaboratively across everything we do, aspiring to help support and create #MoreMoments for the neurodegenerative disease community. Community Guidelines: https://bit.ly/3C1v1wz Please be aware of potential phishing scams imitating Amylyx. All authentic communications from Amylyx will be from the Amylyx.com domain.
