Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
Join the Revolution in Precision Medicine
At Tempus, we're leveraging cutting-edge technology to transform healthcare through AI-powered insights. Our proprietary platform connects real-world evidence to deliver actionable intelligence to physicians, ensuring the right treatments reach the right patients at precisely the right time.
Our Engineering Culture
We operate in small, autonomous teams where developers, designers, scientists, and product managers collaborate closely. You'll have direct ownership in building solutions that make a meaningful impact in cancer research and treatment. Our agile approach and modern architecture enable us to innovate rapidly while maintaining the highest standards of quality and scalability.
About the Role
We are seeking a highly motivated and capable Senior Software Engineer to help advance our Diagnostics initiatives. In this role, you will lead the analysis and design of complex technical problems, architect robust systems, and mentor emerging talent. This position requires deep expertise in full-stack engineering, relational data systems, bioinformatic workflow orchestration, and algorithmic development. As a senior technical leader, you will be expected to craft high-quality code, scale genomic data processing pipelines, leverage modern AI tooling, integrate APIs into user-facing applications, and embed agentic workflows into our core product ecosystem.
Technical Requirements
- 5+ years of advanced TypeScript/JavaScript/python development with a deep understanding of language features and optimization techniques.
- Extensive experience architecting and leading development with Node.js and NestJS frameworks.
- Experience with React development with a demonstrated ability to design and implement complex component systems.
- Proven experience building, scaling, and maintaining bioinformatics orchestration pipelines for high-throughput genomic data analysis using workflow frameworks such as Nextflow.
- Hands-on experience managing, monitoring, and optimizing workflow executions via Seqera Platform (Nextflow Tower) across cloud environments.
- Hands-on experience leveraging GenAI coding tools and autonomous agents (e.g., Copilot, Cursor, LLM APIs) to accelerate development, refactor codebases, and auto-generate comprehensive unit/integration tests.
- Experience or strong working knowledge of integrating APIs and GenAI technologies into production applications.
- Advanced PostgreSQL skills including query optimization, indexing strategies, and performance tuning.
- Proven expertise implementing sophisticated Redis caching solutions for high-throughput systems.
- Demonstrated success designing and implementing distributed microservice architectures that seamlessly interface with data-intensive bioinformatic workflows.
- Significant experience orchestrating infrastructure and applications on GCP, including CI/CD pipelines and cloud-based compute backends for pipeline execution.
- Mastery of enterprise-level design patterns and their practical application in large-scale, mission-critical systems.
What Makes You a Great Fit
- 7+ years of software development experience with a track record of technical leadership.
- Ability to make high-impact architectural decisions that balance business needs, data infrastructure constraints, and scientific computing requirements.
- Track record of bridging the gap between software engineering and computational biology/bioinformatics teams to streamline workflow execution and data delivery.
- Enthusiasm for championing AI-assisted development practices, driving adoption of agentic workflows, and mentoring teams through the evolving landscape of AI tools.
- History of successfully delivering complex projects in fast-paced environments.
- Strong communication skills with experience presenting technical solutions to diverse stakeholders.
- Proven ability to drive cross-team technical initiatives and resolve complex engineering challenges.
Bonus Points
- Advanced expertise in Nextflow (DSL2) custom module/subworkflow development and integration with cloud-native storage/compute engines (e.g., GCP Batch, Life Sciences API, or AWS Batch).
- Experience with search technologies such as Elasticsearch or OpenSearch.
- Experience with containerization orchestration (Docker, Kubernetes).
- Background in biotech, genomics, or precision medicine.
CHI: $110,000-$160,000
The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Skills Required
- 5+ years of advanced TypeScript, JavaScript, and Python development experience
- Extensive Node.js and NestJS development and architecture experience
- Experience developing complex React component systems
- Experience building, scaling, and maintaining bioinformatics orchestration pipelines using workflow frameworks such as Nextflow
- Experience managing, monitoring, and optimizing Nextflow workflows through Seqera Platform across cloud environments
- Experience using GenAI coding tools, autonomous agents, Copilot, Cursor, or LLM APIs
- Experience integrating APIs and GenAI technologies into production applications
- Advanced PostgreSQL skills, including query optimization, indexing, and performance tuning
- Expertise implementing Redis caching solutions for high-throughput systems
- Experience designing distributed microservice architectures for data-intensive bioinformatics workflows
- Experience orchestrating infrastructure and applications on GCP, including CI/CD and cloud compute backends
- Mastery of enterprise-level design patterns in large-scale systems
- 7+ years of software development experience with technical leadership
- Ability to make architectural decisions balancing business, data infrastructure, and scientific computing needs
- Experience collaborating across software engineering and computational biology or bioinformatics teams
- Experience delivering complex projects in fast-paced environments
- Strong communication and technical presentation skills
- Ability to drive cross-team technical initiatives and resolve complex engineering challenges
- Advanced Nextflow DSL2 module or subworkflow development experience
- Experience integrating Nextflow with GCP Batch, Life Sciences API, or AWS Batch
- Experience with Elasticsearch or OpenSearch
- Experience with Docker or Kubernetes
- Background in biotech, genomics, or precision medicine
What the Team is Saying
Tempus AI Compensation & Benefits Highlights
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Healthcare Strength — Healthcare is considered solid, with PPO coverage often described as good and medical, dental, and vision options broadly available. Feedback suggests the overall health offering is a relative strong point despite mixed comments on premiums.
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Leave & Time Off Breadth — Time off is frequently characterized as flexible, with reports of unlimited or generous PTO in many corporate roles. Feedback suggests policies can vary by team, but the offering is generally viewed favorably.
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Wellbeing & Lifestyle Benefits — Workplace perks such as free meals/snacks, on-site amenities like a barista, gym discounts, and commuter benefits are commonly highlighted. Feedback suggests these lifestyle benefits add day-to-day value, especially at larger offices.
Tempus AI Insights
What We Do
We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed. At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information, visit tempus.com.
Why Work With Us
We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.
Gallery
Tempus AI Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
Most of the team follows a hybrid policy, with some roles allowing for a fully remote arrangement and some roles being onsite only.
