Senior Scientist, Translational Biomarkers

Who We Are

Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.

Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.

What Matters to Us

Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.

Arcellx Core Values

• Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work.
• Think ‘we’ before ‘me’: We prioritize collective success, collaborating and supporting one another to achieve our shared goals.
• Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what’s right. 

The “Fine Print” – What You’ll Do

• Design, develop, validate and execute robust fit for purpose clinical biomarker assays to support secondary and exploratory endpoints in clinical safety and efficacy studies.
• Responsible for ensuring biomarker methods are compliant with ICH Q2 guidelines and meet regulatory standards.
• Manage the transfer, bridging and validation of biomarker assays at CROs.
• Contribute to biomarker plans and strategies for addressing key translational questions such as understanding the mechanism of action (MOA), pharmacokinetics and pharmacodynamics of drug candidates.
• Collaborate with external partners, Clinical Operations, Clinical Data Management and Biometrics to advance data acquisition and analyses of clinical trial data.
• Analyze, interpret, prepare and present data summaries, communicate next steps and provide recommendations to internal teams and stakeholders.
• Contribute to regulatory document preparation such as clinical protocol, regulatory responses, and submissions.
• Identify, evaluate and integrate new technologies to support evolving translational biomarker strategies.
• Write and review SOPs, technical protocols and reports.
• May supervise associate scientists and support their professional development.

Skills and Experience We Look For

• PhD in immunology, immuno-oncology, molecular and cellular biology or related field.
• 5+ years of biomarker experience in the pharmaceutical industry. 
• Strong understanding of various technology platforms and datasets used to support clinical biomarker assays used to support early to late phase clinical trials.
• Strong technical expertise in developing, validating and implementation of clinical biomarker, immunological, molecular and gene expression assays including multi-parameter flow cytometry (>12 colors), immunohistochemistry (IHC), droplet digital PCR (ddPCR), RNA isolation/sequencing, gene expression with platform such as Nanostring.
• Subject Matter Expert (SME) on validation of analytical methods per ICH Q2 guidelines.
• Strong data analysis capabilities of high dimensional data using Flowjo or data packages such as Cytobank. Knowledge of R and/or Python is preferred.
• Experience managing CROs and ensuring high-quality, timely delivery of biomarker data, with a demonstrated understanding of ICH/GCP and regulatory requirements.
• Strong problem-solving skills and ability to independently oversee scientific projects, rigorously analyze and interpret scientific data while maintaining attention to detail.
• Effective communication skills, with the ability to present complex data to diverse audiences.
• Experience working in a GCLP regulated environment and extensive knowledge of GLP/GCP complaint studies.

Rewards at Arcellx

Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits.

The estimated base salary range for this position is $125,000 - $145,000 per year. Where a candidate falls within that range is determined by factors such as years of experience. Our compensation package also includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required.

Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more. 

Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to www.arcellx.com.

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