Job Title: Senior Scientist / Principal Scientist – Biotransformation/Metabolite Identification.
Location: Exton, Pennsylvania
Full-time
Job Description:
We are seeking a highly motivated and experienced Senior Scientist specializing in Biotransformation and Metabolite Identification to join our dynamic team. This individual will play a pivotal role in the characterization and identification of drug metabolites, contributing to our understanding of drug metabolism and its impact on drug safety and efficacy.
Key Responsibilities:
- Design, execute, and interpret biotransformation studies to characterize drug metabolites in vitro and in vivo.
- Develop and optimize sample preparation and analytical techniques for metabolite profiling and identification using state-of-the-art LC-MS/MS and high-resolution mass spectrometry (HRMS).
- Interact with clients to provide actionable insights on metabolism-related challenges.
- Prepare and review scientific reports, presentations, and regulatory documents to ensure accuracy and compliance with industry standards.
- Stay updated on advancements in biotransformation and metabolite identification technologies and methodologies.
Qualifications:
- Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
- Strong expertise in drug metabolism and biotransformation, with hands-on experience in metabolite identification using LC-MS/MS and HRMS.
- Knowledge of in vitro (e.g., hepatocytes, microsomes) and in vivo systems for studying drug metabolism.
- Familiarity with regulatory guidelines (e.g., FDA, EMA) for metabolite safety testing (MIST).
- Demonstrated ability to analyze and interpret complex mass spectrometry data and provide detailed reports.
- Excellent communication skills and ability to work collaboratively in a cross-functional team environment.
Preferred Skills:
- Experience with radiolabeled compounds and metabolite profiling.
- Track record of publications or presentations in the field of drug metabolism or biotransformation.
- Hand-on experience on Thermo OrbiTrap or Waters Q-TOF.
What We Offer:
- Competitive salary and benefits package.
- Opportunities for professional growth and development.
- A collaborative and innovative work environment.
Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability
Skills Required
- Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field
- Strong expertise in drug metabolism and biotransformation, with hands-on experience in metabolite identification using LC-MS/MS and HRMS
- Knowledge of in vitro and in vivo systems for studying drug metabolism
- Familiarity with regulatory guidelines for metabolite safety testing
- Ability to analyze and interpret complex mass spectrometry data
- Excellent communication skills and ability to work collaboratively
Frontage Laboratories, Inc Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Frontage Laboratories, Inc and has not been reviewed or approved by Frontage Laboratories, Inc.
-
Healthcare Strength — Health insurance is often described as good or affordable, with medical, dental, and vision consistently included. Feedback suggests this coverage stands out as a solid element of the package.
-
Retirement Support — A company‑matched 401(k) is frequently mentioned and at times characterized as competitive. Access to retirement savings with an employer match is viewed as a meaningful benefit.
-
Leave & Time Off Breadth — PTO is offered with floating holidays and some carryover, with reports of about three weeks to start in certain roles. These features indicate a reasonably comprehensive time‑off structure.
Frontage Laboratories, Inc Insights
What We Do
Frontage Laboratories, Inc. is a CRO that provides integrated, science-driven, product development services throughout the drug discovery and development process to enable pharmaceutical and biotechnology companies to achieve their development goals. Comprehensive services include drug metabolism and pharmacokinetics, analytical testing and formulation development, preclinical and clinical trial material manufacturing, bioanalysis, preclinical safety and toxicology assessment and early phase clinical studies. Frontage has enabled many biotechnology companies and leading pharmaceutical companies of varying sizes to advance a myriad of molecules through development and file regulatory submissions in the United States, China and other countries.
