Senior Scientist, I/O Discovery

Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy. 

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Senior Scientist, I/O Discovery as part of the Exploratory Technology team based in Philadelphia, PA. 

Role Overview

This position will join a new interdisciplinary team focusing on the development of Legend’s engineered cell therapy platform for treating solid tumor.

Qualified candidates should possess proficiency in in vitro and in vivo immune cell phenotypic and functional profiling, anti-tumor immune response by adaptive and innate immune cells and engineered cells for Adoptive Cell Therapy.

The ideal candidate should be driven, analytical, thoughtful and creative, who can function both independently and collaboratively in a fast-paced environment.

This position will report to the Senior Director of Research. Location: Philadelphia.

Key Responsibilities  

• Design and execute CAR-T cell functional assays.
• Phenotypic analysis of T cell differentiation markers.
• Handling and engineering human and murine T cells as well as various cancer cells.
• Analyze and interpret data, troubleshooting, present to and engage cross-functional teams.
• Stay abreast of the latest advancement of cell therapy in solid tumor. Develop relevant insight in selected disease area.

• PhD degree in biological sciences (Immunology, Immuno-Oncology, cancer biology) or related field is required.
• Senior Scientist- PhD +3 years of industry experience.
• Scientist- PhD + 0-2 years of post PhD experience.
• In depth knowledge of T cell development, signaling and differentiation/exhaustion is required.
• Proficiency in conventional immunological techniques such as primary T cell isolation, gene editing/transduction, expansion, ELISA, cell sorting and flow cytometry is required.
• Experience in CAR-T animal models, in vivo study design and execution is a strong plus.
• Experience of high-throughput assay development or screening is preferred but not required.
• Proficiency in single cell transcriptome analysis and data interpretation is a plus.
• In depth knowledge in topics such as human tumor microenvironment (TME), tumor-infiltrating-lymphocytes (TIL), tertiary lymphoid structures (TLS), Immune Checkpoint Blockade (ICB)is preferred.
• Knowledge in GVHD and transplant rejection mechanisms is a plus.
• Innovation in cell therapy space is preferred as evidenced by publications and patents.
• Language: English

#Li-Onsite

#Li-JK1

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.