Jobs at Legend Biotech

The R&D Management Leadership Development Program at Legend Biotech is for recent PhD graduates focusing on cell and gene therapy projects over a 2.5-3 year period, providing broad experience across R&D functions.

The Associate Director, Benefits & Mobility oversees U.S. benefits and mobility programs, ensuring competitive offerings, compliance, and employee engagement. This hands-on role involves managing day-to-day operations, vendor relationships, and program design, while providing strategic insights into global benefit frameworks.

Responsible for leading SAP EWM master data management, designing data governance processes, ensuring compliance, and optimizing manufacturing supply chain data workflows.

The HR Management participant will undergo a structured leadership development program focusing on building strategic and operational capabilities in HR across various functions, coupled with executive mentorship and real-time business impact.

The Executive Director, Pipeline Clinical Lead will oversee early-stage clinical programs, ensuring successful study design, execution, and regulatory compliance while leading a team of scientists and physicians.

Provide business-oriented legal advice and lead drafting, review, negotiation, and execution of a wide range of commercial, procurement, manufacturing, quality, confidentiality, SaaS, and consulting agreements. Partner with Procurement, Finance, IT, Commercial, R&D, Clinical and Medical teams, support contract intake/prioritization, improve contracting processes, maintain templates/playbooks, and assist on ad hoc legal matters and special projects.

The HR Generalist will support HR Business Partners, manage employee relations, assist in talent management, maintain HR databases, and ensure compliance with HR policies.

Manage enterprise applications across Finance, Procurement, and Commercial domains, ensuring system integrity, compliance, and continuous improvement through collaboration with stakeholders.

Lead and execute risk-based internal audits and SOX 404 testing across financial, operational, compliance, and technology areas. Manage full audit lifecycle (planning, fieldwork, reporting, remediation), perform data analysis, document workpapers to COSO/IIA standards, coach junior staff, and collaborate with stakeholders to strengthen controls and drive remediation.

Provide QA compliance oversight for QC laboratories testing advanced cell therapies. Perform spot-checks, walk-throughs, investigations, CAPA oversight, SOP and documentation reviews, audit support, trend analysis, and coach junior QALC staff to ensure GMP compliance and reduce nonconformances.

Lead Supply Chain Finance for manufacturing and network performance, delivering executive-ready financial analysis, forecasting, driver-based models, COGS optimization, and oversight of collaboration agreements and CMO financials. Act as delegate to director, influence cross-functional stakeholders, standardize FP&A processes, and drive automation and continuous improvement to support strategic decision-making and long-range planning.

Manage 2nd-shift CAR-T cell therapy production in a sterile cGMP facility. Oversee supervisors and staff, ensure compliant manufacturing, maintain inspection readiness, support investigations and change controls, create/revise procedures and batch records, coordinate with Manufacturing/Engineering/Quality, drive continuous improvement projects, and lead operational metrics and stakeholder engagement.

Oversee 2nd-shift production of personalized cell therapies in a sterile cGMP environment. Manage and develop staff, assign production schedules, maintain compliance and inspection readiness, support investigations and change control, create/revise operational procedures, partner with Manufacturing/Engineering/Quality, and lead continuous improvement projects to ensure high-quality product supply.

Lead organization design, change management, and leadership development initiatives to improve organizational effectiveness. Partner with business leaders and HRBPs on workforce planning, talent and promotion processes, performance systems, and measurement of OD impact. Drive global programs, culture, and capability building for sustainable growth.

Provide onsite administrative and executive support for the CAR-T manufacturing plant, coordinate communications, maintain organizational records, assist with HR onboarding and recruitment, compile and organize data for presentations and dashboards, track compliance and deliverables, and support special projects for Plant Leadership while handling sensitive information with discretion.

The Sr. QC Analyst is responsible for completing QC testing for cell therapy products, ensuring compliance with procedures and GMP regulations, conducting analytical testing, and collaborating within the Quality team.

The Translational IHC Consultant connects pathology and biomarker development, ensuring quality data for drug mechanisms, target engagement, and safety while collaborating with clinical teams to enhance cancer treatments.

Lead nonclinical toxicology strategy for cell and gene therapy programs, design and interpret GLP safety, pharmacology, biodistribution, and PK studies, manage CRO studies, support IND/CTA and regulatory submissions, assess safety risks (off-target effects, immunogenicity, genome-related risks), and communicate findings across cross-functional teams.

Lead design, optimization, and scale-up of upstream lentiviral vector production (HEK293/HEK293T), develop/validate bioreactor scale-up and scale-down models, enable tech transfer to GMP manufacturing, guide a team, author regulatory and technical documents, and collaborate with downstream and analytics to ensure robust, scalable processes for clinical production.

The Manager, Site Contracts & Payments Management oversees the site contracting and payment processes, ensuring operational effectiveness and collaboration between stakeholders to improve efficiency and financial predictability in clinical studies.