Jobs at Legend Biotech

Lead translational bioinformatics analyses integrating multi-omics and clinical data to discover and validate biomarkers, support patient stratification and mechanism-of-action hypotheses, build reproducible scalable pipelines (cloud/HPC), collaborate with cross-functional teams and contribute biomarker content for regulatory submissions.

Lead site-level quality compliance for a GMP cell therapy manufacturing site, ensuring global GxP alignment, inspection readiness, audit management, CAPA/change control oversight, cross-functional collaboration with J&J, and continuous improvement of quality systems.

Lead nonclinical toxicology strategy for cell and gene therapy programs, design and interpret GLP safety, pharmacology, biodistribution, and PK studies, manage CRO studies, support IND/CTA and regulatory submissions, assess safety risks (off-target effects, immunogenicity, genome-related risks), and communicate findings across cross-functional teams.

The Operations Supervisor oversees daily production in a CAR-T cell therapy environment, ensuring compliance with cGMP regulations and leading a team to meet operational goals.

Lead clinical biomarker programs in immunology and immuno-oncology for hematologic malignancies. Design and analyze clinical translational studies, define MOA, leverage single-cell technologies to profile immune compartments, partner cross-functionally to validate targets, inform patient stratification, and drive biomarker strategies for novel cell therapies.

Lead and supervise CAR-T process operations in a cGMP cleanroom environment. Direct daily production activities, run shift meetings, assign tasks, coach staff, support investigations, revise SOPs and batch records, manage change controls, collaborate with Manufacturing, Engineering, and Quality, and drive continuous improvement while ensuring safety and regulatory compliance. Must be able to perform production tasks as needed and accommodate shift work and overtime.

Senior commercial leader responsible for leading thought leader liaison and clinical educator teams, developing customer engagement strategies, building long-term customer relationships, driving cross-functional collaboration, using data to inform decisions, resolving escalations, managing external communications and events, and coaching high-performing teams to improve sales force sizing and dashboard automation. Position is Bridgewater, NJ–based and requires extensive travel.

Provide scientific leadership and hands-on expertise in multicolor and spectral flow cytometry to develop, qualify, and validate assays supporting IND-enabling studies and clinical trials. Oversee CROs, ensure GxP-compliant data integrity, contribute to regulatory submissions, partner cross-functionally, mentor junior staff, and implement best practices and new technologies to support translational PK/PD and cell/gene therapy programs.

The Carvykti Financial Analyst will support financial planning and analysis, preparing reports, variance analysis, financial models, and partnering with business units for guidance and reporting improvements.

Lead commercial strategic relationships with societies, associations, and scientific organizations to elevate Legend's market presence. Develop and execute external engagement and US strategic business plans, manage multiple projects, translate customer insights into commercial strategies, oversee budgets and resource allocation, and drive organizational upskilling and decision-making as a member of the Commercial Leadership Team.

The Sr. Manager, Biostatistician/Programmer supports clinical development by analyzing clinical trial data, developing TFLs, and collaborating with various teams to inform decision-making.

The QA Investigations Lead oversees quality investigations in a GMP environment, ensuring compliance with regulations, managing CAPA, and supporting audits.

Design and implement scalable bioinformatics pipelines; analyze large multi-omics datasets (RNA-seq, scRNA-seq, WES/WGS, epigenetics) to identify biomarkers and targets; apply statistical and machine learning methods; perform QC, normalization, and batch-correction; integrate public and internal databases; collaborate with biologists, clinicians, and IT to translate computational results into biological insights.

Lead development and enforcement of an enterprise data governance framework for a biotech company. Define policies, stewardship, metadata/catalog management, controls, and KPIs. Collaborate with IT, compliance, and business stakeholders to apply privacy/security controls (Azure/AWS, Microsoft Purview, DLP), resolve data quality issues, drive data literacy, and prioritize governance initiatives to ensure regulatory compliance (GxP, GDPR, SOX) and trusted analytics.

Lead translational strategy from lead optimization through Phase II, integrate and analyze multi-omic datasets (scRNA-seq, CITE-seq, spatial transcriptomics, flow cytometry), identify biomarkers and predictive signatures, partner with clinical teams to implement assays, manage CROs and academic collaborators, and author regulatory and scientific communications.

Lead and mentor engineering teams supporting commercial cell therapy manufacturing. Oversee equipment lifecycle, reliability, qualifications, investigations, CAPA, process optimization, cost-reduction, and regulatory compliance (cGMP/FDA/EMA). Partner cross-functionally to drive continuous improvement, automation, technology transfers, validation, and inspection readiness to ensure uninterrupted, compliant production of cell therapy products.

Develop, optimize, qualify, and execute analytical methods (flow cytometry, cell-based potency, ELISA, viral vector assays) to support product characterization, release, and stability. Author and review methods/protocols, maintain ELN and reagent/instrument records, perform assay qualification and technology transfer, collaborate cross-functionally, ensure data integrity, and present results while following BSL2 and regulatory/ICH expectations.

The Director, Global Strategy Lead will drive enterprise-wide transformation initiatives, integrating strategy and Lean methodologies to ensure effective portfolio management and operational excellence. Responsibilities include developing frameworks for continuous improvement, managing strategic initiatives, and fostering a culture of accountability and performance across the organization.

Perform cGMP manufacturing and support tasks for autologous CAR-T products on 2nd shift. Execute aseptic cell culture, purification, cryopreservation, complete GMP documentation, maintain quality and safety, support continuous improvement, audits, and training progression in a controlled cleanroom environment.

Lead omnichannel analytics for non-personal promotion (NPP), measuring digital and NPP tactic effectiveness, building advanced models (segmentation, propensity, journey analytics), driving test-and-learn, partnering with Commercial, Marketing, IT, and Data Engineering, and delivering executive-ready insights and scalable analytics solutions.