The Role
Conduct independent bench research characterizing antibody-antigen binding using BLI and SPR. Develop epitope binning and competitive binding assays, analyze interactions across diverse antigen and antibody formats, and collaborate with scientists, ML/DS, and program teams to advance antibody candidates. Communicate research findings, manage cross-functional priorities, and help guide scientific direction. Mentorship and lab automation experience are beneficial.
Summary Generated by Built In
The role: BigHat Biosciences is seeking an exceptional individual for a Scientist II or Senior Scientist I in Biomolecular Characterization* role to drive characterization of in vitro antibody-target binding behavior, develop new assay capabilities, and represent the team across BigHat’s programs.
*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more or less experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.
Key Responsibilities
- Develop, optimize, and implement high- and low-throughput state-of-the-art strategies to characterize the interactions between antibody and antigen using biolayer interferometry (BLI) and surface plasmon resonance (SPR).
- Implement best practices for binding assay design across various bioanalytical assay formats.
- Troubleshoot and diagnose assay issues, building foundational understanding of antibody/antigen interactions that stakeholders can act on.
- Collaborate closely with BigHat’s science organization to accelerate hits from discovery through lead optimization and candidate nomination.
- Effectively synthesize and communicate results and research activity to key decision makers and the broader BigHat team.
- Partner with automation engineering, software engineering, and production teams to scale and productionize high-throughput kinetics assays.
Skills Knowledge and Expertise
- Ph.D. 2-5 years, or M.Sc with 5+ years of independent research and development experience in an industry setting, including substantial experience with binding assays including BLI, SPR, ELISA/MSD and Flow Cytometry workflows (preferably across Carterra, Cytiva and Sartorius instrumentation).
- Practical and theoretical fluency in bioanalytical science, biochemistry, biophysics, assay design and development (experience in both complex and buffered matrices preferred).
- Experience with lab automation and working with automation engineers (preferred).
- Strong data analysis and interpretation skills coupled to exceptional written, verbal, and visual communication skills.
- Ability to educate and build consensus among diverse stakeholders regarding scientific direction.
Total Rewards
The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
About
BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these design capabilities to develop new generations of safer and more effective treatments for patients suffering from today’s most challenging diseases.BigHat is a Series B biotech outside San Francisco with a team-oriented, inclusive, and family-friendly culture. Our broad pipeline of wholly-owned and partnered therapeutic programs span many disparate indications with high unmet need, such as cancer, inflammation, and infectious disease. BigHat has raised >$100M from top investors, including Section 32, a16z, and 8VC.
Skills Required
- M.Sc. or Ph.D. in molecular biology, cell biology, immunology, or a related field
- 5+ years of advanced, independent research experience in an industry setting
- Substantial experience with Octet BLI and/or Biacore platforms
- Practical and theoretical fluency using various BLI sensor types to determine antibody-antigen binding kinetics and perform epitope binning
- Deep technical knowledge of chip chemistries and characteristics for SPR measurements
- Experience measuring binding interactions with recombinant soluble, transmembrane, and cell-based antigens
- Experience working with a variety of antibody formats
- Ability to manage and prioritize requests from cross-functional stakeholders
- Strong data analysis and interpretation skills
- Exceptional written, verbal, and visual communication skills
- Ability to educate diverse stakeholders and build consensus regarding scientific direction
- Experience managing teams or mentoring junior scientists
- Experience with lab automation
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The Company
What We Do
BigHat’s mission is to improve human health by making it far easier to design advanced, next-generation antibody therapeutics. Our AI-enabled experimental platform integrates a high-speed characterization or “wet” lab with machine learning technologies to speed the antibody engineering process. When applied, these design capabilities have the potential to drive the development of new generations of safer and more effective treatments for patients suffering from today’s most challenging diseases. BigHat is backed by Section 32, Andreessen Horowitz, 8VC, Amgen Ventures, Bristol Myers Squibb, Quadrille, Grids Capital, AME Cloud Ventures, Innovation Endeavors and Gaingels.
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