Senior Scientist, GPCR Pharmacology

Why Patients Need You
Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
Role Summary
The key strategic focus area within the Internal Medicine Research Unit (IMRU) is identifying novel therapies to prevent or treat diseases associated with diabetes or the metabolic syndrome including NASH, obesity, renal disease and heart failure. We aim to build a world class research team dedicated to developing a deep mechanistic understanding of the metabolic pathways and molecular targets underlying disease pathogenesis. As a member of the discovery pharmacology team, you will be playing a significant role in the drug discovery process including validation of novel targets and optimization of effective therapeutics. Experience studying the molecular pharmacology G-protein receptors (GPCRs) is essential and familiarity with the pathophysiology of dysmetabolic states would be advantageous. In addition, the individual will help build and facilitate collaborations with partners in the academic scientific community, as well as within the larger Pfizer network. She/he will have daily interactions with a team of creative and innovative scientists, working collaboratively in a supportive environment to conduct rigorous scientific drug discovery research. Strong self-motivation, excellent communication and interpersonal skills, and the ability to both lead as well as thrive as part of a team are essential.
Role Responsibilities
Successful candidates will be expected to:

• Independently conceptualize, design and conduct in vitro studies aimed at dissecting the complex molecular pharmacology of emerging therapeutic modulators targeting GPCRs.
• Translate experimental results to advance our understanding of receptor biology and help define how physiological endpoints are impacted by pharmacological agents.
• Maintain an awareness of 'cutting edge' scientific and technical developments in preclinical to clinical translation and apply these to advance the portfolio programs.
• Apply creative thinking and scientific expertise to the formulation of strategies to identify and validate novel therapeutic targets in key areas of interest to the IMRU.
• Mentor junior scientists in developing skills essential to the execution of rigorous research.
• Build and facilitate collaborations with partners in the academic scientific community, as well as within the Pfizer network of scientists.
• Present research findings to Pfizer colleagues and the scientific community through publication in peer-reviewed journals and talks and posters at scientific meetings.
• Present and represent research programs to Pfizer leadership.
• Ensure that all research/discovery work is conducted with highest quality and ethical guidelines and in accordance with relevant regulatory, QC, and compliance guidelines.

Qualifications

• PhD with a minimum of 2 years of post-doc or relevant research experience.
• Deep expertise in GPCR molecular pharmacology, including hands-on experience with traditional and novel screening methodologies and concepts related to GPCR drug discovery, signaling and trafficking.
• Scientific rigor with demonstrated ability to review critically available data and think independently and creatively in formulating and testing novel scientific hypotheses.
• Excellent communication and interpersonal skills and ability to work independently and as part of an interdisciplinary team in a collaborative environment.
• Successful record of scientific accomplishments supported by previous publications in high-impact pharmacology journals and presentations at international conferences.
• Ability to mentor junior colleagues both technically and scientifically.

Relocation support available
Work Location Assignment: On Premise
The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
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