Computational Chemist, Senior Scientist

Posted Yesterday
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Tokyo, JPN
Hybrid
Senior level
Healthtech • Machine Learning • Software • Biotech • Pharmaceutical
Opening new worlds for molecular discovery
The Role
Supports drug discovery projects through computational chemistry and molecular modeling, using methods such as virtual screening, lead optimization, AI/ML, molecular dynamics, quantum mechanics, cheminformatics, and ADMET/QSPR. Collaborates with interdisciplinary global teams and software developers to improve drug discovery technologies. Requires a relevant PhD, business-level English and Mandarin, and computational drug discovery expertise; Japanese, postdoctoral experience, or industry experience are preferred.
Summary Generated by Built In

We’re seeking a Computational Chemist to join the Schrodinger Therapeutics Group as a Senior Scientist in our mission to transform the discovery of therapeutics and materials! 

Our drug discovery group of over 60 scientists includes designers, modelers, computational chemists, medicinal chemists, crystallographers, biochemists, and biologists with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers, as well as a large scale computer infrastructure. Four of the programs we’ve worked on in the past seven years have progressed into the clinic; two are still progressing through trials and two have been approved by the FDA. 

This employee will be hired at the Senior Scientist level.

Who will love this job: 

  • A structure-based drug designer who has experience in at least two of the following molecular modeling areas: virtual ligand screening, computationally-driven lead optimization, AI/machine learning, molecular dynamics, quantum mechanics, cheminformatics, ADMET/QSPR 
  • An excellent communicator with experience in one or more other disciplines of relevance to drug discovery, such as synthetic organic chemistry, pharmacology, toxicology, formulation, biochemistry, physical chemistry, or analytical chemistry 
  • A team player who enjoys working in interdisciplinary environments and has some background in programming/scripting and/or chemically-aware databases 
  • An accomplished pharma/biotech professional 

What you’ll do: 

  • Support active drug discovery projects as a computational chemist/modeler 
  • Collaborate across global, cross-functional teams in multiple languages, accounting for differences in time zone and work culture
  • Work closely with internal software development teams to improve our drug discovery technologies 

What you should have: 

  • PhD in computational chemistry, organic chemistry, or physical chemistry
  • Postdoctoral experience and/or at least one year of industry experience is preferred
  • Business level proficiency in English and Mandarin
  • Business level proficiency in Japanese preferred, but not required

Pay and Perks:
Schrödinger understands that it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, bonus plan, and benefits, which includes mutual-aid retirement plans, over three weeks of paid vacation time, numerous company holidays, a parental and family care leave program, and healthcare through our partnership with the Japanese Health Insurance Association, and professional development opportunities including trainings and continuous education support.

Why Schrödinger:
You will join a global scientific organization developing and applying advanced computational technologies to improve human health and quality of life.  This role offers the opportunity to work with leading life-science organizations in Japan, contribute to important scientific challenges, collaborate with international experts, and shape the adoption of next-generation computational methods in drug discovery.

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Schrödingerでは、医薬品と材料の探索・開発に変革をもたらすというミッションのもと、Schrödinger Therapeutics GroupにSenior Scientistとして参画いただける計算化学者を募集しています。

当社の創薬研究グループは、分子設計、分子モデリング、計算化学、メディシナルケミストリー、結晶構造解析、生化学、生物学を専門とする60名以上の研究者で構成されています。主要な標的クラス

および幅広い治療領域での研究経験を有し、100名以上のソフトウェア開発者・エンジニアと大規模な計算インフラが、その研究活動を支えています。過去7年間に当社が携わった創薬プログラムのうち、4件が臨床開発段階に進み、そのうち2件は現在も臨床試験が進行中で、2件は米国食品医薬品局(FDA)の承認を取得しています。

本ポジションは、Senior Scientistとしての採用となります。

求める人物像

  • 構造に基づく創薬・分子設計の経験を有し、以下の分子モデリング分野のうち、少なくとも2分野で実務経験をお持ちの方
    バーチャルリガンドスクリーニング、計算化学を活用したリード最適化、AI・機械学習、分子動力学、量子力学、ケモインフォマティクス、ADMET予測・定量的構造物性相関(QSPR)
  • 優れたコミュニケーション能力を備え、合成有機化学、薬理学、毒性学、製剤学、生化学、物理化学、分析化学など、創薬に関する他の専門分野においても、1分野以上の経験をお持ちの方
  • 多様な専門性を持つメンバーとの協働を楽しみ、チームワークを大切にできる方。また、プログラミング・スクリプティング、また化学構造情報を扱うデータベースに関する基礎知識や経験をお持ちの方
  • 製薬企業またはバイオテクノロジー企業で実績を積まれた方

主な業務内容

  • 計算化学・分子モデリングの専門家として、進行中の創薬プロジェクトを支援する
  • 時差や働き方・文化の違いを踏まえ、複数の言語を用いて、グローバルかつ部門横断的なチームと協働する
  • 社内のソフトウェア開発チームと緊密に連携し、当社の創薬技術の改善、高度化に貢献する

応募資格

必須要件

  • 計算化学、有機化学、または物理化学の博士号
  • ビジネスレベルの英語力および中国語

歓迎要件

  • 博士研究員として研究経験、または1年以上の企業での実務経験
  • ビジネスレベルの日本語(必須レベルではありません)

報酬・福利厚生

Schrödingerは、優れた会社をつくるのは「人」であると考えています。そのため、競争力のある給与、賞与制度に加え、以下を含む福利厚生と成長機会を提供しています。

  • 退職金共済制度
  • 年間3週間を超える年次有給休暇
  • 充実した会社指定休日
  • 育児介護休業制度
  • 全国健康保険協会(協会けんぽ)を通じた健康保険
  • 研修や継続的な学習支援など、専門性の向上とキャリア開発の機会

Schrödingerで働く魅力

Schrödingerは、人々の健康と生活の質の向上を目指し、先進的な計算科学技術の開発と応用に取り組むグローバルなサイエンス企業です。

本ポジションでは、日本の主要なライフサイエンス企業・研究機関と連携し、重要な科学課題の解決に貢献できます。また、世界各国の専門家と協働しながら、創薬における次世代の計算科学的手法の導入・活用を推進する機会があります。

Skills Required

  • PhD in computational chemistry, organic chemistry, or physical chemistry
  • Business-level proficiency in English
  • Business-level proficiency in Mandarin
  • Experience in at least two molecular modeling areas, such as virtual ligand screening, computational lead optimization, AI/machine learning, molecular dynamics, quantum mechanics, cheminformatics, or ADMET/QSPR
  • Experience in structure-based drug design
  • Experience in at least one additional drug discovery discipline, such as synthetic organic chemistry, pharmacology, toxicology, formulation, biochemistry, physical chemistry, or analytical chemistry
  • Background in programming or scripting and/or chemically-aware databases
  • Professional experience in pharmaceutical or biotechnology organizations
  • Postdoctoral experience or at least one year of industry experience
  • Business-level proficiency in Japanese
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The Company
HQ: New York, NY
885 Employees
Year Founded: 1990

What We Do

Schrödinger is a leading provider of advanced molecular simulations and enterprise software solutions and services for pharmaceutical, biotechnology, and materials science research. The predictive power of Schrödinger's software allows scientists to accelerate their research and development, reduce research costs, and make novel discoveries.

Why Work With Us

We have a mission-driven culture that thrives off team collaboration. By utilizing a non-hierarchal approach, we hope to give all employees a voice and room to grow to their fullest potential. We actively engage in diversity and inclusion efforts, pay fairly, and always strive to provide a supportive atmosphere for our teams.

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