Adaptimmune is a fully integrated commercial-stage cell therapy company, designed and built from the ground up with UK- and U.S.-based biotechnology hub locations. In the U.S., locations are in Cambridge, MA and Philadelphia, PA. In the UK, locations are in Oxford and Stevenage. Our comprehensive capabilities and teams include preclinical research, clinical development, translational sciences, autologous and allogeneic manufacturing, and in-house commercial and corporate operations.
Our company culture is rooted in trust, inclusion, our capacity to collaborate, and our commitment to being honest and brave in our desire to successfully transform the lives of people with cancer.
This Senior Scientist will join the Analytical Development team to develop, optimize, and perform qualification/validation work on numerous analytical methods for early/late-stage cell therapy. Extensive experience with potency assays, molecular assays, flow cytometry, cell culture, and T cells is required. Experience in T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functionally closed cell systems would also be a plus.
Your primary responsibilities will include design and execution of experiments, and authorship of technical protocols and reports. Additional activities include method optimization and method qualification. This position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.
Key Responsibilities
- Plan, design, conduct, analyze, interpret experiments mostly independently
- Lead the development of assays for clinical and preclinical use
- Design and execute qualification/validations of assays
- Label and store samples
- Maintain databases
- Fully Analyze and write up results in electronic lab notebooks in a timely manner
- Prepare documentation, including study plans, SOPs (protocols), batch records, experimental evaluation and summary, study reports, etc.
- Proactively seek input from colleagues to progress own projects as well as actively share own experience and knowledge to help progress colleagues’ projects.
- Contribute to routine lab maintenance as well as be considerate to colleagues, abiding by the lab rules and working in a safe, clean and tidy manner
- If available and appropriate, project work-stream leadership/management and/or supervision and training of other junior scientists
Qualifications and Experience
- Degree in biochemistry, chemical engineering, or related discipline
- Substantial and relevant post-graduate experience within academic or industry setting, preferably including an MSc or PhD in a relevant scientific area
- Extensive relevant experience of laboratory procedures, including cell culture and ideally flow cytometry or other vector-based analytical methods
- Experience with developing and troubleshooting assays and ideally with evaluating assay performance
- Experience in analytical assay development, and familiarity with regulatory guidelines around assay validation.
Desirable
- An in depth understanding of immunology/T cell biology, cell-based assays (i.e. Potency), molecular assays, and flow cytometry
- Experience working with lentiviral vectors and primary human T cells including T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functionally closed cell systems
- Experience working with quality systems
Top Skills
What We Do
Adaptimmune, a leader in T-cell therapy, is a multinational, clinical-stage biopharmaceutical company focused on developing novel immunotherapies using its proprietary SPEAR T-cell receptor platform to treat solid tumors, which has the potential to transform the treatment of cancer. Our proprietary SPEAR T-cell platform has generated a strong pipeline of affinity-enhanced T-cell therapies, with multiple INDs open. We use these therapies to harness the body's own immune system to find and destroy diseased cells. Our SPEAR TCR therapies offer promise to patients that often have no other options. We are working hard to make that promise a reality.
