Senior Scientist - ADC Immunology

Why Patients Need You
Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
What You Will Achieve
At Pfizer we deliver breakthroughs that change patients' lives. Pfizer's Oncology Research Unit (ORU) is seeking a Senior Scientist to join the ADC Immunology team based in Bothell, Washington. ADC Immunology plays a vital role in discovering and advancing novel ADCs by comprehensive biological evaluation of payload mechanisms of action and dissecting multicellular interactions in the tumor microenvironment. The ideal candidate will be a motivated, detail-oriented, highly collaborative, organized, and flexible scientist with a strong background in cancer immunology, particularly in mechanisms of immunogenic cell death, tumor immunogenicity or immunosuppression.
How You Will Achieve It

• Apply cellular and molecular biology laboratory techniques to preclinical research projects in the area of cancer immunology
• Execute molecular and cellular assays including flow cytometry, cytotoxicity assays, reporter assays, ELISA, Luminex, western blotting, WES and in vitro PD assays
• Investigate novel antibody drug conjugate (ADC) linker payloads and new MOAs of our therapeutics through development, optimization, and execution of complex assays
• Independently design, execute and document key experiments to enable clear go/no-go decisions; present findings to large and small audiences
• Provide leadership within technical area of expertise; may train others
• Maintain rigorous records of experimental progress using electronic laboratory notebooks

Qualifications
Must-Have

• Ph.D or equivalent in cancer immunology, cancer biology, biomedical sciences, or a related field
• Experience with tissue culture, cell-based immune function assays and immunophenotyping, diverse molecular biology techniques, and preclinical animal models of cancer
• Ability to adapt and adjust to a rapidly evolving environment
• Ability to use critical thinking to address challenges and overcome obstacles independently
• Strong written and verbal communication skills with the ability to communicate effectively to a wide range of audiences

Nice-to-Have

• Postdoctoral or industry experience
• Background in oncology, cancer biology, cancer drug discovery and ADCs
• Expertise in characterizing effects of chemical or genetic perturbation in vitro and in vivo, such as mechanisms of immunogenic/regulated cell death or immunogenicity of small molecules/biologics
• Experience with antibody effector function assays (ADCP, ADCC, CDC)
• Experience with single-cell and/or spatial -omics
• Experience with biological data analysis in R/Python

\nRelocation support available\n
Work Location Assignment: On Premise
The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development