Independently sets up and performs experiments and procedures in support of lab goals and grant commitments (e.g. assays, cell/tissue culture, animal studies, etc.). Contributes to the planning, design and modification of studies and experiments in the research lab setting. Monitors results, reports unusual outcomes and suggests modifications. Collects, enters, summarizes, and analyzes data. May oversee and assist with the training of residents, fellows and temporary lab personnel in lab techniques. Works with minimal supervision and performs assignments independently as discussed and approved by Principal Investigator.
Precision Mouse Engineering Core of Mayo Clinic provides innovative tools for the next generation of genetically modified mice for all members of the Mayo Research community. The Transgenic and Knockout Core, directed by Darren Baker, Ph.D., is also a shared resource of the Mayo Clinic Cancer Center. The core provides services to all Mayo Clinic faculty and staff engaged in research. Additionally, services are offered to non-Mayo investigators and research collaborators.
Precision Mouse Engineering Core is seeking an experienced Sr. Research Technologist to join their team. Expertise in the following areas is highly desired:
- Experience working with mice: Husbandry, hyperovulation, embryo microinjection and transfer, surgery.
- Molecular biology expertise: In general, genotyping, cloning, primer design, DNA purification, gel electrophoresis, and sequencing knowledge/experience. Knowledge of CRISPR mediated genetic manipulation is highly desired.
- Superior attention to detail, communication, and follow-through on tasks.
This vacancy is not eligible for sponsorship/ we will not sponsor or transfer visas for this position. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.
Qualifications
Requires bachelor's degree in biology, chemistry, or other relevant science with 4 years of research laboratory experience. Master's degree in biology, chemistry, or other relevant science preferred.
About UsMayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
- Medical: Multiple plan options.
- Dental: Delta Dental or reimbursement account for flexible coverage.
- Vision: Affordable plan with national network.
- Pre-Tax Savings: HSA and FSAs for eligible expenses.
- Retirement: Competitive retirement package to secure your future.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.
Skills Required
- Bachelor's degree in biology, chemistry, or relevant science
- Minimum 4 years of research laboratory experience
- Master's degree in biology, chemistry, or relevant science
- Experience working with mice: husbandry, hyperovulation, embryo microinjection and transfer, surgery
- Molecular biology skills: genotyping, cloning, primer design, DNA purification, gel electrophoresis, sequencing
- Knowledge of CRISPR-mediated genetic manipulation
- Experience with cell and tissue culture and animal studies
- Superior attention to detail, communication, and follow-through
Mayo Clinic Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Mayo Clinic and has not been reviewed or approved by Mayo Clinic.
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Retirement Support — A no-cost pension plus an employer-matched 403(b)/401(k) is positioned as a standout differentiator, offering strong long-term financial security. Feedback suggests this retirement combination elevates overall total rewards even when base pay is moderate.
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Healthcare Strength — Expanded medical networks, enhanced fertility coverage, and employer absorption of a plan year’s premium increases point to robust healthcare offerings. Feedback suggests annual updates maintain breadth and competitiveness of coverage.
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Parental & Family Support — Adoption assistance, dependent scholarships, child and elder-care resources, and EAP services provide meaningful family-oriented support. Feedback suggests these programs add tangible value beyond salary alone.
Mayo Clinic Insights
What We Do
Mayo Clinic is the first and largest integrated, not-for-profit medical group practice in the world. Doctors from every medical specialty work together to care for patients, joined by common systems and a philosophy of "the needs of the patient come first." More than 3,800 physicians and scientists and 50,900 allied health staff work at Mayo Clinic, which has sites in Rochester, Minn., Jacksonville, Fla., and Scottsdale/Phoenix, Ariz. Mayo Clinic also serves over 70 communities through Mayo Clinic Health System with locations in MN, IA, and WI. Collectively, these locations care for more than 1 million people each year.







