Senior Research Associate / Scientist – Immunology and Inflammation

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San Diego, CA, USA
In-Office
Artificial Intelligence • Biotech
The Role
Genesis Therapeutics is a leader in AI guided rational drug design with the goal to address unmet medical needs in various indications, including oncology and immunology.

Our San Diego lab is recruiting a Senior Research Associate/Scientist with experience in cellular and molecular immunology, assay development, cell biology and/or biochemistry, with a proven interest in addressing inflammatory and autoimmune diseases.More specifically, we are seeking a candidate who establishes cell-based in vitro assays to investigate mechanisms of action and supports compound progression for multiple targets. This is a hands-on, lab-based position that requires close collaboration with colleagues across multiple functions. Educational requirements consist of an advanced degree (MSc or PhD) in a relevant field, complemented by industry experience proportional to the level of education.

Learn more about us at https://www.genesistherapeutics.ai/

As an integral member of the team, you will:

  • Autonomously plan, design, and execute cell- and patient sample-based experiments to support our I&I pipeline.
  • Maintain a hands-on approach while contributing intellectually to experimental and project needs.
  • Analyze, interpret and integrate complex datasets across multiple assay types.
  • Document data meticulously using ELN and state-of-the-art analysis tools.
  • Stay at the forefront of latest research through literature review and critical evaluation of available data sources.
  • Ensure team progress and success through efficient communication with key personnel across the organization.

Your Qualifications are:

  • A MSc, or PhD degree in immunology, molecular and cell biology, or a related field, with 5+ (with MSc) or 3+ (with PhD) years of relevant industry experience, respectively.
  • A meticulous and detail-oriented approach to experimental design, with full commitment to scientific rigor and creative solutions.
  • A solid understanding of autoimmune and inflammatory mechanisms combined with a passion for pre-clinical drug research as evidenced by previous work experience.
  • Proven experience with high-quality, immune-relevant assays for compound profiling and MOA evaluations, including but not limited to activation/proliferation assays, cell differentiation, co-culture experiments, cytokine analysis, immune phenotyping, ex vivo culture and functional profiling of blood.
  • Fluency with MSD, Luminex, or other multiplex assays for bio-analyte quantification.
  • Robust experience with multi-color flow cytometry.
  • Experience in live cell imaging, IF staining, high-content/high-throughput imaging and quantitative image analysis is a plus.
  • Critical understanding of assay development and validation for screening and compound progression purposes.
  • A highly organized workstyle with excellent written and oral communication skills.
  • Practical know-how with industry standard equipment like automated plate readers, liquid handlers, and robotic platforms is highly valued.
  • Proficiency with data visualization and statistical analysis using contemporary software tools is a must.

What we offer:

  • Participation in the growth of a pioneering company in AI-driven drug discovery.
  • Integration into a dynamic, collaborative and forward-thinking environment.
  • Engagement with a multidisciplinary team to tackle challenging projects with a meaningful impact on patient lives

In addition, we provide:

  • Competitive Pay
  • Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees)
  • Stock Option Eligibility
  • 401(k) Plan
  • Open PTO Policy
  • Paid Company Holidays
  • Free lunch and snacks at our offices

Genesis Therapeutics is unifying AI and biotech to discover novel and breakthrough treatments for patients with severe and devastating conditions. Genesis was founded on groundbreaking molecular ML research and since has established itself as the industry leader in AI for small molecule drug discovery. Our team of accomplished biotech leaders and expert drug hunters joins forces with deep learning researchers and software engineers who are pioneering predictive and generative AI technologies for molecules.

Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets. 

The company has leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged. In addition, Genesis has signed AI-focused platform collaborations with major pharmaceutical companies, including most recently Incyte Corporation (Feb 2025) and Gilead Sciences (Sept 2024).

We raised a $200M series B in August 2023, and have raised over $300M in funding from top technology and biotech investors, including Andreessen Horowitz, Rock Springs Capital, T. Rowe Price, Fidelity, Radical Ventures, NVentures (NVIDIA's VC arm), BlackRock, and Menlo Ventures. 

Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.

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The Company
HQ: Burlingame, CA
58 Employees

What We Do

Genesis Therapeutics is unifying AI and biotech to accelerate and optimize drug discovery. We pioneer novel deep learning and molecular simulation techniques to accelerate the development of new medicines. Genesis raised its $52M Series A from top tech + biotech investors, Andreessen Horowitz, Rock Springs, and T. Rowe Price. Story: https://techcrunch.com/2020/12/02/genesis-therapeutics-raises-52m-a-round-for-its-ai-focused-drug-discovery-mission/ We deploy our technology to accelerate a pipeline of several internal drug programs. Furthermore, Genesis has announced two significant, multi-target collaborations with Genentech and with Eli Lilly, the latter of which entailed a $20M upfront payment with a $670M total deal size. Now we are scaling the team and technology to support many more programs in parallel as well as increasingly difficult protein targets. We currently have a team (genesistherapeutics.ai/company.html#team) of about 35 people, split 50/50 between our ML / software team and our biochem team of veteran drug hunters in our own wetlab space. Our ML + software engineers are top-notch -- many graduates from MIT, UC Berkeley, Stanford. Previously worked at OpenAI, Google, Facebook, MemSQL, Jane Street, Dropbox, etc. We're recruiting pure ML research scientists + software engineers (no bio or chem experience expected) to further our core AI platform as well as scale our drug pipeline. Likewise, we have several openings in chemistry and biology to join our team of biotech + pharma veterans who are deploying the Genesis ML platform to discover novel drug candidates. Please apply on our website, or feel free to reach out via email directly: [email protected]

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