Who Are We?
Our company is based on the science of our founder, Stanley Qi, one of the original CRISPR co-inventors who then furthered the technology so that DNA does not need to be cut to accomplish gene regulation. Instead, we regulate the epigenome to suppress and activate multiple genes simultaneously. We are further evolving the platform and leveraging its strengths to address unmet medical needs.
We are looking for exceptional team members who want an active role in building a rapidly growing biotech.
Title: Research Associate II/Senior Research Associate, Process Development
Location: South San Francisco, CA
Opportunity:
Epicrispr Biotechnologies is seeking a highly motivated Senior Research Associate to join our Process Development team. This individual will contribute to the development and optimization of our in-house AAV platform, support preclinical vector supply, and play an active role in day-to-day lab operations. The ideal candidate is a hands-on experimentalist with strong experience in mammalian cell culture and viral vector production, who thrives in a fast-paced, collaborative startup environment. This role will support the development of scalable and robust processes to advance our gene regulation platform.
Roles and Responsibilities:
- Execute upstream AAV production (2-5L) using transient transfection in suspension cell culture, supporting iterative process improvements
- Conduct studies to develop representative scale-down models for manufacturing processes
- Contribute to DoE studies (shake flasks) and process characterization experiments to evaluate and define critical process parameters (CPPs) and assess their impact on critical quality attributes (CQAs)
- Support upstream production campaigns to meet preclinical material demands on schedule and within quality expectations
- Assist in generating and analyzing data sets to support process development reports, tech transfer documents, and internal presentations
- Perform and analyze dPCR and flow cytometry experiments
- Maintain thorough, accurate, and timely documentation of experimental methods, data, and results
- Support general lab operations including equipment maintenance, reagent and consumable inventory management, vendor coordination, and sample tracking
- Collaborate cross-functionally with Research, Analytical Development, and Manufacturing teams
Qualifications:
- B.S. degree in Cell Biology, Biochemistry, Biology, or a related discipline with 4+ years of relevant industry experience (or M.S. with 2+ years)
- Hands-on experience with mammalian cell culture (adherent and suspension), aseptic technique, and transient transfection
- Demonstrated proficiency in benchtop bioreactor AAV production (inoculation through clarification)
- Familiarity with AAV or viral vector production
- Experience with analytical methods such as PCR/dPCR and flow cytometry
- Solid data analysis skills with ability to interpret complex results, communicate findings, and recommend next steps
- Familiarity with statistical design and analysis, including Design of Experiments (DoE), is preferred
- Exceptional attention to detail with proven excellence in experimental documentation
- Strong critical thinking and creative problem-solving skills
- Self-motivated, proactive and takes initiative when managing multiple priorities
- Collaborative team player who communicates openly and effectively within department and cross-functionally
- Prior experience in a startup environment is a plus
Compensation: The salary range for this position is $80,000 to $108,000 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.
Epicrispr Biotechnologies is an early-stage biotechnology company developing a novel technology platform that can provide safe and persistent control of targeted gene regulation. Our proprietary platform represents an entirely new class of therapeutics that can be leveraged to treat severe disease across numerous therapeutic areas, including complex diseases impacted by multiple genes.
Epicrispr Biotechnologies provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.
This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.
Skills Required
- B.S. degree in Cell Biology, Biochemistry, Biology, or related discipline with 4+ years industry experience
- Hands-on experience with mammalian cell culture, aseptic technique, and transient transfection
- Demonstrated proficiency in benchtop bioreactor AAV production
- Familiarity with AAV or viral vector production
- Experience with analytical methods such as PCR/dPCR and flow cytometry
- Solid data analysis skills
- Familiarity with statistical design and analysis, including Design of Experiments
- Exceptional attention to detail in experimental documentation
- Strong critical thinking and creative problem-solving skills
- Self-motivated and takes initiative in managing priorities
- Collaborative team player with effective communication
- Prior experience in a startup environment
What We Do
Epicrispr Biotechnologies is a biotechnology company developing ultracompact therapies to modulate gene expression in vivo using the smallest known Cas protein, CasMINI
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