NewLimit is seeking a Senior Research Associate with strong experience in molecular biology and translational biomarker assay development to join our team. This role will contribute to the development and execution of pharmacokinetic (PK) and pharmacodynamic (PD) assays to support our therapeutic programs. You will work closely with cross-functional teams to develop and implement molecular assays that quantify the biodistribution of our mRNA-LNP medicines and the biological response to them in preclinical studies.
What you’ll do- Develop, validate, and execute PK and PD biomarker assays to support preclinical studies and therapeutic discovery programs
- Design and perform molecular biology assays (e.g., qPCR, RT-qPCR, ddPCR, NGS-based assays, ELISA) to quantify nucleic acids, gene and protein expression in biological samples
- Contribute to experimental sample processing and preparation workflows including animal dissections, tissue harvesting, and primary cell culture
- Collaborate with our Epigenetic Editing team to perform large-scale, single cell perturbation experiments
- Perform state-of-the-art single cell profiling experiments to map epigenetic features of aging
- Bachelor’s degree in molecular biology, cell biology, biochemistry, or a related scientific field
- 2+ years of laboratory experience in molecular biology and quantitative assay development (e.g., qPCR, RT-qPCR, ddPCR, ELISA, NGS-based)
- Hands-on experience with primary cell culture, tissue harvesting and complex biological matrices for molecular assays
- Familiarity with bioanalytical assay qualification/validation principles for PK/PD biomarker measurements
- Understanding of data quality, documentation, and experimental practices aligned with preclinical regulatory expectations (e.g., GLP-like practices or bioanalytical method validation guidelines)
- Experience working in environments following GLP or regulated bioanalytical workflows supporting preclinical or IND-enabling studies
- Experience with flow cytometry sorting
- Experience with NGS methods
NewLimit provides generous benefits so our team can remain focused on our mission:
- Comprehensive Health, Dental, and Vision insurance
- 401(k) plan with company match
- Paid parental leave
- Industry-leading PTO: 20 days per year plus holidays
- On-site meals and snacks
Salary Range: $90,000 to $110,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.
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What We Do
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
